Patents by Inventor Stephen L. Gwaltney

Stephen L. Gwaltney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dipeptidyl peptidase inhibitors
    Patent number: 8288539
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: October 16, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Glucokinase Activators
    Publication number: 20120252814
    Abstract: Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: March 21, 2012
    Publication date: October 4, 2012
    Applicant: TAKEDA CALIFORNIA, INC.
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Joanne Miura, Mark Sabat, Mingnam Tang, Haxia Wang
  • Glucokinase Activators
    Publication number: 20120225887
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: April 10, 2012
    Publication date: September 6, 2012
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Zacharia Cheruvallath, Stephen L. Gwaltney, Andrew John Jennings, Mark Sabat, Jeffrey A. Stafford, Mingnam Tang, Haxia Wang
  • Dipeptidyl peptidase inhibitors
    Patent number: 8222411
    Abstract: Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: July 17, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Paul R. Brodfuahrer, Bruce Elder, Paul Isbester, Richard S. Fornicola, Philip B. Kisanga, Bingidimi I. Mobele, Grant J. Palmer, Maxwell M. Reeve, Jonathon S. Salsbury, Luckner Ulysse, Sripathy Venkatraman
  • Dipeptidyl peptidase inhibitors
    Patent number: 8188275
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 29, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Apoptosis signal-regulating kinase 1 inhibitors
    Patent number: 8178555
    Abstract: The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: May 15, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Edcon Chang, Stephen L. Gwaltney, Angie Vassar
  • Glucokinase activators
    Patent number: 8173645
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: May 8, 2012
    Assignee: Takeda San Diego, Inc.
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Joanne Miura, Mark Sabat, Mingnam Tang
  • Dipeptidyl peptidase inhibitors
    Patent number: 8173663
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 8, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Glucokinase activators
    Patent number: 8163779
    Abstract: Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: April 24, 2012
    Assignee: Takeda San Diego, Inc.
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Joanne Miura, Mark Sabat, Mingnam Tang, Haxia Wang
  • Renin inhibitors
    Patent number: 8133898
    Abstract: The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:—wherein the variables are as defined herein.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: March 13, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Stephen L. Gwaltney, Zhiyuan Zhang, Betty Lam
  • Imidazopyridine compounds
    Patent number: 8124617
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: February 28, 2012
    Assignees: Takeda San Diego, Inc., Takeda Pharmaceutical Company Limited
    Inventors: Hidehisa Iwata, Yasuhisa Kohara, Sheldon X. Cao, Prasuna Guntupalli, Stephen L. Gwaltney, David J. Hosfield, Yan Liu, Jeffrey A Stafford, Beverly Wolgast
  • Dipeptidyl peptidase inhibitors
    Patent number: 8093382
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: January 10, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Michael B. Wallace, Jeffrey A. Stafford, Zhiyuan Zhang
  • INDAZOLE COMPOUNDS FOR ACTIVATING GLUCOKINASE
    Publication number: 20110301155
    Abstract: The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like.
    Type: Application
    Filed: June 18, 2008
    Publication date: December 8, 2011
    Inventors: Tsuneo Yasuma, Shigekazu Sasaki, Osamu Ujikawa, Yasufumi Miyamoto, Stephen L. Gwaltney, Sheldon Cao, Andy Jennings
  • GLUCOKINASE ACTIVATORS
    Publication number: 20110275665
    Abstract: Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: July 18, 2011
    Publication date: November 10, 2011
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Sheldon X. Cao, Jun Feng, Stephen L. Gwaltney, David J. Hosfield, Robert J. Skene, Jeffrey A. Stafford, Mingnam Tang
  • Glucokinase activators
    Patent number: 8034822
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: October 11, 2011
    Assignee: Takeda San Diego, Inc.
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Stephen W. Kaldor, Joanne Miura, Mark Sabat, Mingnam Tang, Beverly Wolgast
  • Substituted indazoles as glucokinase activators
    Patent number: 8008332
    Abstract: Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: August 30, 2011
    Assignee: Takeda San Diego, Inc.
    Inventors: Sheldon X. Cao, Jun Feng, Stephen L. Gwaltney, David J. Hosfield, Robert J. Skene, Jeffrey A. Stafford, Mingnam Tang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7960384
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: June 14, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl Peptidase Inhibitors
    Publication number: 20110087022
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Application
    Filed: December 9, 2010
    Publication date: April 14, 2011
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • GLUCOKINASE ACTIVATORS
    Publication number: 20110070297
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
    Type: Application
    Filed: December 1, 2010
    Publication date: March 24, 2011
    Applicants: Takeda San Diego, Inc., Takeda Pharmaceutical Company Limited
    Inventors: Sheldon X. Cao, Jun Feng, Yasuhiro Imaeda, Stephen L. Gwaltney, David J. Hosfield, Nobuyuki Takakura, Mingnam Tang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7906523
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: March 15, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse