Patents by Inventor Stephen L. Gwaltney

Stephen L. Gwaltney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and uses thereof for the modulation of hemoglobin
    Patent number: 9981939
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: May 29, 2018
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Brian W. Metcalf, Zhe Li, Qing Xu, Stephen L. Gwaltney, II, Jason R. Harris, Calvin W. Yee
  • Compounds and uses thereof for the modulation of hemoglobin
    Patent number: 9957250
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 1, 2018
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Brian W. Metcalf, Jason R. Harris, Zhe Li, Stephen L. Gwaltney, II
  • Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
    Patent number: 9802900
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 31, 2017
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Stephen L. Gwaltney, II, Jason R. Harris
  • Pyrazolopyridine pyrazolopyrimidine and related compounds
    Patent number: 9695166
    Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: July 4, 2017
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Qing Xu, Chul Yu, Calvin Yee, Stephen L. Gwaltney, II, Brian W. Metcalf, Steven Richards, Matthew A. Lardy, Lina Setti, Hing Sham
  • COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20160332984
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: December 28, 2015
    Publication date: November 17, 2016
    Inventors: Brian W. Metcalf, Jason R. Harris, Zhe Li, Stephen L. Gwaltney, II
  • COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20160083343
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 10, 2014
    Publication date: March 24, 2016
    Applicant: Global Blood Therapeutics, Inc
    Inventors: Qing XU, Zhe LI, Stephen L. GWALTNEY, II
  • COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20160046613
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 10, 2014
    Publication date: February 18, 2016
    Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
    Inventors: Brian W. METCALF, Zhe LI, Qing XU, Stephen L. GWALTNEY, II, Jason R. HARRIS, Calvin W. YEE
  • COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20160031865
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 10, 2014
    Publication date: February 4, 2016
    Applicant: Global Blood Therapeutics, Inc.
    Inventors: Zhe LI, Qing XU, Brian W. METCALF, Stephen L. GWALTNEY, II, Jason R. HARRIS, Calvin W. YEE
  • COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20160031904
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 10, 2014
    Publication date: February 4, 2016
    Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
    Inventors: Zhe LI, Qing XU, Brian W. METCALF, Stephen L. GWALTNEY, II, Jason R. HARRIS, Calvin W. YEE
  • COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20160024127
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 10, 2014
    Publication date: January 28, 2016
    Applicant: Global Blood Therapeutics, Inc.
    Inventors: Jason R. HARRIS, Brian W. METCALF, Zhe LI, Stephen L. GWALTNEY, II
  • Glucokinase Activators
    Publication number: 20160009735
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: September 21, 2015
    Publication date: January 14, 2016
    Inventors: Zacharia Cheruvallath, Stephen L. Gwaltney, Andrew John Jennings, Mark Sabat, Mingnam Tang, Haixia Wang, Jeffrey A. Stafford
  • PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS
    Publication number: 20150315198
    Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Applicant: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Qing Xu, Chul Yu, Calvin Yee, Stephen L. Gwaltney,, II, Brian W. Metcalf, Steven Richards, Matthew A. Lardy, Lina Setti, Hing Sham
  • Glucokinase activators
    Patent number: 9139598
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: September 22, 2015
    Assignee: Takeda California, Inc.
    Inventors: Zacharia Cheruvallath, Stephen L. Gwaltney, Andrew John Jennings, Mark Sabat, Mingnam Tang, Haixia Wang, Jeffrey A. Stafford
  • BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20150259296
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 17, 2015
    Inventors: Zhe Li, Stephen L. Gwaltney, II, Jason R. Harris
  • Compounds and uses thereof for the modulation of hemoglobin
    Publication number: 20140274961
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: Global Blood Therapeutics, Inc.
    Inventors: Brian W. Metcalf, Jason R. Harris, Zhe Li, Stephen L. Gwaltney, II
  • Glucokinase Activators
    Publication number: 20140045859
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: October 2, 2013
    Publication date: February 13, 2014
    Applicant: Takeda California, Inc.
    Inventors: Zacharia Cheruvallath, Stephen L. Gwaltney, Andrew John Jennings, Mark Sabat, Mingnam Tang, Haixia Wang, Jeffrey A. Stafford
  • Pyrazole and fused pyrazole glucokinase activators
    Patent number: 8563730
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: October 22, 2013
    Assignee: Takeda San Diego, Inc.
    Inventors: Zacharia Cheruvallath, Stephen L. Gwaltney, Andrew John Jennings, Mark Sabat, Jeffrey A. Stafford, Mingnam Tang, Haxia Wang
  • Glucokinase activators
    Patent number: 8530499
    Abstract: Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: September 10, 2013
    Assignee: Takeda San Diego, Inc.
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Joanne Miura, Mark Sabat, Mingnam Tang, Haxia Wang
  • Substituted isoindoles as glucokinase activators
    Patent number: 8394843
    Abstract: Compounds are provided which have the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture which contain such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to activate glucokinase.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: March 12, 2013
    Assignee: Takeda California, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Robert J. Skene, Mingnam Tang, Sheldon X. Cao, David J. Hossfield, Jeffrey A. Stafford
  • Dipeptidyl peptidase inhibitors
    Patent number: 8329900
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: December 11, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse