Patents by Inventor Stephen L. Gwaltney

Stephen L. Gwaltney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dipeptidyl peptidase inhibitors
    Patent number: 7872124
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: January 18, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7825242
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein R2 is amino (C1-6)alkyl, hetero(C3-12)cycloakyl, hetero(C4-12)bicycloaryl, heteroaryl, or cyano; and W, X, Y, Z, R1, R5 and R7 are as defined herein.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: November 2, 2010
    Assignee: Takeda Pharmaceutical Company Limted
    Inventors: Jun Feng, Stephen L. Gwaltney, Betty Lam, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7795428
    Abstract: Compounds are provided for use with DPP-IV of the formula: Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: September 14, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey Alan Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathan S. Salsbury, Luckner Ulysse
  • Dipeptidyl peptidase inhibitors
    Patent number: 7790736
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: September 7, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7790734
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: September 7, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Sheldon X. Cao, Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Xiao-Yi Xiao, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7781584
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: August 24, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Dipeptidyl peptidase inhibitors
    Patent number: 7732446
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formulae: where the substituents are as described herein.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: June 8, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Stephen L. Gwaltney, Jeffrey A. Stafford, Michael B. Wallace, Laurence E. Burgess, Scott D. Cowen, Stephen S. Gonzales, Ellen R. Laird, Xiaodong Wang
  • RENIN INHIBITORS
    Publication number: 20100137310
    Abstract: The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:—wherein the variables are as defined herein.
    Type: Application
    Filed: March 11, 2008
    Publication date: June 3, 2010
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Stephen L. Gwaltney, Betty Lam, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7723344
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: May 25, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7687638
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: March 30, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Michael B. Wallace, Zhlyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7687625
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C?NR9; and R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: March 30, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • IMIDAZOPYRIDINE COMPOUNDS
    Publication number: 20100069431
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
    Type: Application
    Filed: September 1, 2006
    Publication date: March 18, 2010
    Inventors: Hidehisa Iwata, Yasuhisa Kohara, Sheldon X. Cao, Prasuna Guntupalli, Stephen L. Gwaltney, David J. Hosfield, Yan Liu, Jeffrey A. Stafford, Beverly Throop
  • Dipeptidyl peptidase inhibitors
    Patent number: 7678909
    Abstract: Compounds are provided which may be used to inhibit DPP-IV comprising the formula: wherein the substituents are as described in the specification and claims.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: March 16, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Laurence E. Burgess, Scott D. Cowen, Stephen L. Gwaltney, II, Jeongboeb Seo, Jeffrey A. Stafford
  • Dipeptidyl peptidase inhibitors
    Patent number: 7638638
    Abstract: Pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound with the formula: where the labeled substituents are as described herein.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: December 29, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Michael B. Wallace, Xiao-Yi Xiao, Zhiyuan Zhang
  • APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS
    Publication number: 20090318425
    Abstract: The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: June 23, 2009
    Publication date: December 24, 2009
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Edcon Chang, Stephen L. Gwaltney, Angie Vassar
  • Glucokinase Activators
    Publication number: 20090286800
    Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 19, 2009
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Zacharia Cheruvallath, Stephen L. Gwaltney, Andrew John Jennings, Mark Sabat, Jeffrey A. Stafford, Mingnam Tang, Haxia Wang
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20090275750
    Abstract: Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
    Type: Application
    Filed: September 15, 2006
    Publication date: November 5, 2009
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Paul R. Brodluahrer, Bruce Elder, Paul Isbester, Richard S. Fornicola, Philip B. Kisanga, Bingidimi I. Mobele, Grant J. Palmer, Maxwell M. Reeve, Jonathon S. Salsbury, Luckner Ulysse, Sripathy Venkatraman
  • Dipeptidyl peptidase inhibitors
    Patent number: 7579357
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: August 25, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhlyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7550590
    Abstract: Compounds, pharmaceuticals, kits, and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C?NR9; and R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: June 23, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • GLUCOKINASE ACTIVATORS
    Publication number: 20090105255
    Abstract: Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: December 17, 2007
    Publication date: April 23, 2009
    Inventors: Zacharia Cheruvallath, Jun Feng, Prasuna Guntupalli, Stephen L. Gwaltney, Joanne Miura, Mark Sabat, Mingnam Tang, Haxia Wang