Patents by Inventor Stephen Turner

Stephen Turner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10294523
    Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: May 21, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Benjamin Flusberg, Jonas Korlach, Jeffrey Wegener, Tyson A. Clark, Igor Drasko Vilfan, Andrey Kislyuk, Stephen Turner, Jon Sorenson, Kevin Travers, Cheryl Heiner, Austin B. Tomaney, Patrick Marks, Jessica Lee, Lei Jia, Dale Webster, John Lyle, Jeremiah Hanes
  • Publication number: 20190138285
    Abstract: Disclosed are various examples for deploying applications on client devices through a management service. A client device can be enrolled with a management service. The management service can determine application settings that are associated with an application and generate an application profile for the application. The application profile can be used to deploy the application to client devices and provision the application with the appropriate application settings.
    Type: Application
    Filed: January 2, 2019
    Publication date: May 9, 2019
    Inventors: Stephen Turner, Scott Kelley
  • Publication number: 20190136311
    Abstract: A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 9, 2019
    Inventors: Stephen Turner, Jonas Korlach, Steven Warren
  • Patent number: 10273537
    Abstract: Real time redox sequencing methods, devices, and systems are described. Arrays of redox devices comprising one or two electrodes are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the electrode(s). A sequencing reaction mixture comprising nucleotide analogs comprising redox labels is introduced to the array of redox devices under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by electrochemically identifying the redox labels of the nucleotide analogs that are incorporated into the growing strand.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: April 30, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jonas Korlach, Stephen Turner, Lei Sun
  • Publication number: 20190106741
    Abstract: Real time electronic sequencing devices, chips, and systems are described. Arrays of nanoFET devices are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound to the nanoFET. The nanoFET devices typically have a source, a drain and a gate comprising a nanowire. A single polymerase enzyme complex comprising a polymerase enzyme complexed with the template nucleic acid is bound to the gate. The polymerase is bound to the gate non-covalently through a polymeric binding agent that has two strands, each strand interacting with the nanowire such that the polymerase is in a central location between the strands with the polymeric binding agent extending away from the polymerase complex along the nanowire in both directions.
    Type: Application
    Filed: September 20, 2018
    Publication date: April 11, 2019
    Inventors: Stephen Turner, Jonas Korlach, Satwik Kamtekar, Jeremiah Hanes
  • Publication number: 20190068568
    Abstract: Disclosed are various examples for distributed profile and key management. In one example, a management service can generate a partially populated device profile and provide the partially populated device profile to a client application executable on a client device. The client application can generate a credential and insert the credential into the partially populated device profile to generate a fully populated device profile. The credential can be shared with at least one other client application on the client device. The management service can use the fully populated device profile to generate multiple profiles that rely on a single credential, such as a single X.509 security certificate.
    Type: Application
    Filed: August 24, 2017
    Publication date: February 28, 2019
    Inventors: Eugene Liderman, Jonathon Deriso, William Thomas Hooper, Sagar Date, Tejas Mehrotra, Stephen Turner, Amogh Datar, Dipanshu Gupta
  • Publication number: 20190065725
    Abstract: Disclosed are various examples for distributed profile and key management. In one example, a client device can include an agent application and a PIV-D application. The agent application can receive a partially populated device profile generated by a management service to configure a setting on the client device. The PIV-D application can generate a derived credential and provide the derived credential to the agent application. The agent application can modify the partially populated device profile to include the credential to create a fully populated device profile and configure the client device in accordance with the fully populated device profile.
    Type: Application
    Filed: August 24, 2017
    Publication date: February 28, 2019
    Inventors: Eugene Liderman, Jonathon Deriso, William Thomas Hooper, Sagar Date, Tejas Mehrotra, Stephen Turner, Amogh Datar, Dipanshu Gupta
  • Publication number: 20190064421
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
    Type: Application
    Filed: July 9, 2018
    Publication date: February 28, 2019
    Inventors: Annette GROT, Shang WANG, Hans CALLEBAUT, Paul LUNDQUIST, Stephen TURNER
  • Patent number: 10190158
    Abstract: A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: January 29, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Jonas Korlach, Steven Warren
  • Publication number: 20190024162
    Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
    Type: Application
    Filed: January 19, 2018
    Publication date: January 24, 2019
    Inventors: Jonas Korlach, Stephen Turner, Tyson A. Clark
  • Patent number: 10180834
    Abstract: Disclosed are various examples for deploying applications on client devices through a management service. A client device can be enrolled with a management service. The management service can determine application settings that are associated with an application and generate an application profile for the application. The application profile can be used to deploy the application to client devices and provision the application with the appropriate application settings.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: January 15, 2019
    Assignee: Airwatch LLC
    Inventors: Stephen Turner, Scott Kelley
  • Publication number: 20190001047
    Abstract: A flow control system of a clinical perfusion system comprises flow control devices 110, such as pumps, valves and/or clamps, capable of controlling a fluid flow rate according to flow rate parameters from the flow control system. The flow control system comprises an indicator arrangement including a device indicator 122a, 122b on each flow control device 110 capable of providing a plurality of indications. The device indicators 122a, 122b are controllable by the flow control system to indicate an active condition of the flow control device 110 independently of the flow rate parameters. This allows the indication provided by the device indicator 122a, 122b to be adjusted for different clinical environments, and to provide colour indications that match the colour range discernible by users affected by colour vision deficiency.
    Type: Application
    Filed: June 28, 2018
    Publication date: January 3, 2019
    Inventor: Stephen Turner
  • Publication number: 20180344918
    Abstract: An exhaust gas flow control system for an oxygenator of an extracorporeal ventilation system connected to an oxygenation gas supply line and to an exhaust line for removal of exhaust gas comprises a flow control path, a pressure control path, an exhaust flow regulator responsive to the controller, and an exhaust gas pressure regulator responsive to a controller configured to maintain a pre-determined pressure level in the exhaust line. This provides a better degree of control over the pressure across the oxygenator from oxygenation gas inlet to exhaust.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 6, 2018
    Inventors: Stephen Turner, Benjamin David Garbutt
  • Publication number: 20180344912
    Abstract: A control system in a blood line (12) of a cardiopulmonary bypass perfusion system (1) comprises a flow sensor (26) to determine a flow value indicative of the flow rate, a controller configured to process the flow value, and an adjustable restriction (28) responsive to the controller, to reduce the flow rate in the venous blood line (12) to maintain a flow rate to the venous blood reservoir that does not exceed a restriction threshold. As the adjustable restriction (28) is responsive to the flow sensor (26), this provides a closed loop control mechanism that avoids restricting the blood line (12) of the perfusion system (1) more than intended.
    Type: Application
    Filed: November 10, 2016
    Publication date: December 6, 2018
    Inventor: Stephen Turner
  • Patent number: 10144963
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: December 4, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Paul Lundquist, Stephen Turner
  • Patent number: 10138515
    Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: November 27, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
  • Patent number: 10125391
    Abstract: Real time electronic sequencing methods, devices, and systems are described. Arrays of nanoFET devices are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound to the nanoFET. A sequencing reaction mixture comprising nucleotide analogs having conductivity labels is introduced to the array of nanoscale electronic elements comprising nanoFETs under conditions of polymerase mediated nucleic acid synthesis. The polymerase enzyme template complex is attached to the gate of the nanoFET in an orientation whereby the nucleotide exit region of the polymerase enzyme is directed toward the gate of the nanoFET. Methods for producing nanoFET arrays are provided.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: November 13, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Jonas Korlach, Satwik Kamtekar, Jeremiah Hanes
  • Publication number: 20180285172
    Abstract: Disclosed are various examples for exchanging data between applications installed on a mobile device. An app-to-app messaging protocol is provided that an application developer can leverage to exchange information with other applications without the application developer needing to fully implement the protocol.
    Type: Application
    Filed: March 28, 2017
    Publication date: October 4, 2018
    Inventors: Stephen Turner, Sandeep Naga Kaipu, Dipanshu Gupta
  • Publication number: 20180264187
    Abstract: A control system controlling the line pressure in a blood supply system (1) in which a pump (14) pumps blood from a reservoir (10) via a primary passage (18) toward a plurality of outlets (16, 26, 26a), wherein one or more outlets are openable to permit flow and closable to block flow, said control system comprises a monitoring arrangement to determine a line pressure in the primary passage, and a controller responsive to the monitoring arrangement and controlling the pump (14) to maintain the line pressure in the primary passage (18) above a pre-set level. The control system practically eliminates the risk of a momentary reduction in blood supply line pressure when an outlet is opened.
    Type: Application
    Filed: September 8, 2016
    Publication date: September 20, 2018
    Inventor: Stephen Turner
  • Patent number: RE47067
    Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. The invention includes devices having sample and reference pores connecting sample, measurement and reference chambers, wherein potential measurements in each chamber is used to provide an accurate determination of current through a sample nanopore, improving nanopore sequencing.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: October 2, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Nathaniel McCaffrey, Jeffrey Wegener, Adrian Fehr