Patents by Inventor Stephen Turner

Stephen Turner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200164335
    Abstract: The present invention provides methods, compositions, and systems for distributing single polymerase molecules into array regions. In particular, the methods, compositions, and systems of the present invention result in a distribution of single polymerase molecules into array regions at a percentage that is larger than the percentage expected to be occupied under a Poisson distribution.
    Type: Application
    Filed: November 21, 2019
    Publication date: May 28, 2020
    Inventors: Lei Sun, Natasha Popovich, Gene Shen, Thang Pham, Stephen Turner
  • Patent number: 10655172
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 19, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ronald L. Cicero
  • Publication number: 20200149100
    Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
    Type: Application
    Filed: October 21, 2019
    Publication date: May 14, 2020
    Inventors: Stephen Turner, Jon Sorenson, Kenneth Mark Maxham, John Eid
  • Publication number: 20200153697
    Abstract: Disclosed are various examples for Internet of Things (IoT) device discovery and deployment. In some embodiments, a device identifier is received from an IoT device. The IoT device is determined, based on the device identifier, to be associated with a device account with a management service. An enrollment of the IoT device is performed. A capabilities declaration is received from the IoT device. IoT device instructions are determined based on the capabilities declaration. IoT device instructions are transmitted to the IoT device, causing it to perform a capability specified in the capabilities declaration.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 14, 2020
    Inventors: Stephen Turner, Daniel E. Zeck, Simon Brooks
  • Patent number: 10646637
    Abstract: A cardioplegic agent delivery system comprises a syringe pump for providing cardioplegic agent into a carrier fluid of a perfusion system, a flow sensor for sensing a flow of the carrier fluid, and an interlock responsive to the flow sensor. The interlock prevents operation of the syringe pump in the absence of carrier fluid flow sensed by the flow sensor. This provides increased safety in a cardioplegic agent delivery system.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 12, 2020
    Assignee: Spectrum Medical Ltd.
    Inventor: Stephen Turner
  • Patent number: 10651895
    Abstract: Disclosed are various examples for provisioning a client device through near-field communication (NFC). An administrator device can provide configuration parameters to a client device in a factory-reset condition through an NFC bump. A second NFC bump can be performed that provides enrollment parameters to the client device, after which the client device can complete enrollment with an enterprise mobility management (EMM) service.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: May 12, 2020
    Assignee: Airwatch LLC
    Inventors: Stephen Turner, Scott Kelley
  • Publication number: 20200141918
    Abstract: The invention relates to methods for nanopore sequencing. A substrate such as a semiconductor is provided having a nanopore or an array of nanopores connecting an upper solution with a lower solution. A polymerase-nucleic acid complex comprising a strand displacing DNA polymerase and a circular nucleic acid template and components required for DNA synthesis are provided. The polymerase produces a nascent DNA strand complementary to the circular nucleic acid template and this nascent strand is translocated through the nanopore while it is being produced by a polymerase-nucleic acid complex comprising a strand displacing DNA polymerase and a circular nucleic acid template and providing the components required for DNA synthesis whereby the polymerase produces a nascent DNA strand which is translocated through the nanopore while the nascent DNA strand is being produced. The sequence of the nascent DNA strand is determined while it translates through the pore using the measured current over time.
    Type: Application
    Filed: September 18, 2019
    Publication date: May 7, 2020
    Inventors: Stephen Turner, Benjamin Flusberg
  • Patent number: 10640818
    Abstract: Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 5, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Thang Tat Pham, Yu-Chih Tsai, Jonas Korlach, Tyson A. Clark, Stephen Turner
  • Patent number: 10640825
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: May 5, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Publication number: 20200137594
    Abstract: Disclosed is a virtual wireless base station that can dynamically scale its capacity to meet changes in demand for connectivity. The virtual wireless base station includes a plurality of virtual baseband modules, a plurality of interface/router modules, an orchestrator module and a fabric mapper module. Each of the plurality of virtual baseband modules is coupled to the interface/router modules by a low latency switch fabric. The orchestrator determines current and near future demand for connectivity within the virtual wireless base station and either instantiates and connects new virtual baseband processors to meet a rise in demand, or shuts down underutilized virtual baseband processors in case of insufficient demand.
    Type: Application
    Filed: October 30, 2019
    Publication date: April 30, 2020
    Inventors: Massimo Notargiacomo, Jeffrey Courington, Stephen Turner, Jeffrey Masters, Vishal Agrawal, Francesco Foresta
  • Patent number: 10637723
    Abstract: Various examples relate to the configuration of enterprise workspaces that can be provided in computing devices. In some examples, a computing device is enrolled with a management service that controls operating of at least a portion of the computing device. A management component creates a user account with a distributor of the operating system based on an email address and a password. The user account is associated with an enterprise workspace of the computing device.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: April 28, 2020
    Assignee: Airwatch LLC
    Inventors: Scott Harlow Kelley, Adarsh Subhash Chandra Jain, Stephen Turner
  • Publication number: 20200102613
    Abstract: Sequencing methods, devices, and systems are described. Arrays of nanoscale electronic elements comprising two electrodes separated by an insulating layer are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the insulating region. A sequencing reaction mixture comprising nucleotide analogs having impedance labels is introduced to the array of nanoscale electronic elements under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by identifying the types of labels of the nucleotide analogs that are incorporated into the growing strand using measured impedance.
    Type: Application
    Filed: October 30, 2019
    Publication date: April 2, 2020
    Inventors: Stephen Turner, Jeremiah Hanes, Keith Bjornson
  • Publication number: 20200086034
    Abstract: A control system is provided to restrict the flow rate of blood in a venous line 12 of a perfusion system 1 comprising a reservoir 10 supplied by the venous line 12 and supplying an outgoing line 22. The control system comprises an outgoing flow sensor 32 configured to determine an outgoing flow value indicative of the outgoing flow rate in the outgoing line 22, and a controller configured to process the outgoing flow value and to determine if the outgoing flow value exceeds a pre-set pairing threshold.
    Type: Application
    Filed: December 19, 2017
    Publication date: March 19, 2020
    Inventor: Stephen Turner
  • Patent number: 10590484
    Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 17, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jonas Korlach, Stephen Turner, Tyson A. Clark
  • Patent number: 10592226
    Abstract: Disclosed are various examples for deploying applications on client devices through a management service. A client device can be enrolled with a management service. The management service can determine application settings that are associated with an application and generate an application profile for the application. The application profile can be used to deploy the application to client devices and provision the application with the appropriate application settings.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: March 17, 2020
    Assignee: Airwatch LLC
    Inventors: Stephen Turner, Scott Kelley
  • Patent number: 10578788
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. In some embodiments, the devices comprise an optical waveguide comprising a plurality of optical cores and a cladding, a plurality of nanometer-scale apertures disposed on a surface of the device above the optical waveguide, such that optical energy passing through the plurality of optical cores of the optical waveguide illuminates the plurality of nanometer-scale apertures by an evanescent field that emanates from the waveguide, and a plurality of detectors optically coupled to the plurality of nanometer-scale apertures. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: March 3, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
  • Publication number: 20200068418
    Abstract: Disclosed is a system and methods for creating and maintaining a virtual subnetwork of telecommunication base stations within a wider telecommunication network. In an LTE-based example, the subnetwork includes a connection aggregator that is coupled between the plurality of eNodeBs internal to the subnetwork and one or more MMEs in the outer network. The connection aggregator intercepts all control plane messages between the MMEs and the internal eNodeBs, remaps eNodeB identifiers, and transmits repackaged messages so that the outer network sees the entire subnetwork as a single “giant” eNodeB. The disclosed system and methods enables the operator of the virtual subnetwork to add and shut down eNodeBs as demand for connectivity fluctuates, and to do so such that all changes are unseen by the outer network.
    Type: Application
    Filed: August 22, 2019
    Publication date: February 27, 2020
    Inventors: Jeffrey Courington, Vishal Agrawal, Sasi Eswarakava, Massimo Notargiacomo, Stephen Turner, Patrick William Henkle
  • Patent number: 10570450
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: February 25, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Paul Lundquist, Stephen Turner
  • Patent number: 10563255
    Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 18, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Jon Sorenson, Kenneth Mark Maxham, John Eid
  • Patent number: 10562766
    Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided. Arrays of confined regions are produced wherein each confined region comprises a single island within the confined region. The island can be selectively functionalized with a coupling agent to couple a single molecule of interest within the confined region.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: February 18, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Ron Kuse, Gregory Kearns, Pezhman Monadgemi, Mathieu Foquet, Drew Martinez