Abstract: A cassette obtainable from a blank having a chassis and first and second compression members is provided. The chassis has a series of four first parallel folding lines, a second and a third folding lines individuating a series of a closure flap, a cover panel, a front panel, a bottom panel and a rear panel. The second and third folding lines respectively individuate a left flap of each panel and a right flap of each panel, each of the left and right flaps being separated from adjacent left and right flaps by cuts. A first compression member has a center panel fixed to an internal face of the chassis on the rear panel. A second compression member is fixed to the internal face of the chassis on the cover panel. The cover panel has detachment lines delimiting first and second foldable buffers. The front panel has detachment lines delimiting a winglet.

Abstract: Disclosed is a virtual base station capable of hosting multiple network operators and/or private networks in a single compute environment. The virtual base station includes a plurality of virtual baseband processors configured to communicate with the plurality of mobile network operators, a supervisor module, a fronthaul network interface configured to be coupled to one or more remote units, and a KPI (Key Performance Indicator) coordinator module coupled to the supervisor module and the one or more virtual baseband processors. The base station may have on or more CBRS (Citizens Broadband Radio Service) Daemons to act as a proxy for obtaining grants to CBRS channels and allocating the CBRS channels to the mobile network operators.

Abstract: The disclosure relates to a particulate composition comprising ensifentrine, wherein the particulate composition further comprises: from greater than 0.00 wt % to 0.60 wt % of 1,3-bis(2-(2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea (BMIQU) relative to the total weight of ensifentrine; and from 0.00 wt % to 0.50 wt % of a biuret impurity of formula (A) relative to the total weight of ensifentrine. Further disclosed herein are liquid pharmaceutical compositions comprising the particulate composition, and a process for producing the particulate composition are also described.

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

Abstract: A heater-cooler apparatus of an extracorporeal perfusion system comprises at least one fluid circuit 102, 104 providing a supply of a heat transfer fluid to the perfusion system, a cold storage unit 266, and a refrigeration unit 250 for charging the cold storage unit 266. The cold storage unit 266 comprises a chamber 312 containing a liquid that freezes at a temperature above that to which the heat transfer fluid is cooled by the refrigeration unit 250, and a passage through which the heat transfer fluid is conveyed, the passage extending through the chamber 312. This allows a more effective cold storage unit to be provided.

Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.

Abstract: A heater-cooler apparatus of an extracorporeal perfusion system comprises at least one fluid circuit (102, 104) providing a supply of a heat transfer fluid to the perfusion system, a cold storage unit (266), and a refrigeration unit (250) for charging the cold storage unit (266). The cold storage unit (266) comprises a chamber (312) containing a liquid that freezes at a temperature above that to which the heat transfer fluid is cooled by the refrigeration unit (250), and a passage through which the heat transfer fluid is conveyed, the passage extending through the chamber (312). This allows a more effective cold storage unit to be provided.

Abstract: The disclosure relates to a particulate composition comprising ensifentrine, wherein the particulate composition further comprises: from greater than 0.00 wt % to 0.60 wt % of 1,3-bis(2-(2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea (BMIQU) relative to the total weight of ensifentrine; and from 0.00 wt % to 0.50 wt % of a biuret impurity of formula (A) relative to the total weight of ensifentrine. Further disclosed herein are liquid pharmaceutical compositions comprising the particulate composition, and a process for producing the particulate composition are also described.

Abstract: In some aspects, a computing system can generate and optimize a machine learning model to estimate an unobservable capacity of a target system or entity. The computing system can access training vectors which include training predictor variables, training performance indicators, and task quantities. A training performance indicator indicating performance outcome corresponding to the predictor variables and a task quantity associated with a task assigned to the target entity that leads to the training performance indicator. The machine learning model can be trained by performing adjustments of parameters of the machine learning model to minimize a loss function defined based on the training vectors. The trained machine learning model can be used to estimate the capacity of the target system or entity for handling tasks and be used in assigning tasks to the target entity according to the determined capacity.

Abstract: The present invention is directed toward a hair catching device for drains designed to catch hair and other debris and prevent unwanted clogs and backups in plumbing systems. The hair catching device for drains is designed to fit within standard sink, bathtub, and shower drains, comprising a single body with an upper and lower portion, wherein said lower portion is comprised of legs with hook elements for entangling and collecting hair and other debris. The hair catching device for drains is flexible for simple installation and removal and provides an effective solution in preventing clogs and backups.

Abstract: Disclosed is a system and methods for creating and maintaining a virtual subnetwork of telecommunication base stations within a wider telecommunication network. In an LTE-based example, the subnetwork includes a connection aggregator that is coupled between the plurality of eNodeBs internal to the subnetwork and one or more MMEs in the outer network. The connection aggregator intercepts all control plane messages between the MMEs and the internal eNodeBs, remaps eNodeB identifiers, and transmits repackaged messages so that the outer network sees the entire subnetwork as a single “giant” eNodeB. The disclosed system and methods enables the operator of the virtual subnetwork to add and shut down eNodeBs as demand for connectivity fluctuates, and to do so such that all changes are unseen by the outer network.

Abstract: The disclosure relates to a particulate composition comprising ensifentrine, wherein the particulate composition further comprises: from greater than 0.00 wt % to 0.60 wt % of 1,3-bis(2-(2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea (BMIQU) relative to the total weight of ensifentrine; and from 0.00 wt % to 0.50 wt % of a biuret impurity of formula (A) relative to the total weight of ensifentrine. Further disclosed herein are liquid pharmaceutical compositions comprising the particulate composition, and a process for producing the particulate composition are also described.

Abstract: The disclosure relates to a particulate composition comprising ensifentrine, wherein the particulate composition further comprises: from greater than 0.00 wt % to 0.60 wt % of 1,3-bis(2-(2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido [6,1-a]isoquinolin-3(4H)-yl)ethyl)urea (BMIQU) relative to the total weight of ensifentrine; and from 0.00 wt % to 0.50 wt % of a biuret impurity of formula (A) relative to the total weight of ensifentrine. Further disclosed herein are liquid pharmaceutical compositions comprising the particulate composition, and a process for producing the particulate composition are also described.

Abstract: A wireless telecommunications base station that compensates for Doppler shift in each connected User Equipment. The base station deploys a plurality of parallel receivers, each with a given frequency offset above and below the carrier frequency. Each receiver performs a frequency shift on a common uplink signal, determines the quality of the frequency shifted uplink signal, and demodulates the frequency shifted uplink signal. A selector/combiner module generates a highest quality demodulated signal, which may be done by selecting the frequency shifted uplink signal or soft combining a subset of frequency shifted uplink signals having a sufficiently high quality.

Abstract: A gas supply control system for an oxygenator of an extracorporeal ventilation system is configured for connection to external gas supply ports for oxygen and nitrogen in the form of air and to create a supply gas output from oxygen and nitrogen. The gas supply control system includes two or more gas output lines and configured to supply the two or more gas output lines with the supply gas output. The flow rates through the gas output lines may be modulated differently.

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

Abstract: Disclosed is a virtual wireless base station that can dynamically scale its capacity to meet changes in demand for connectivity. The virtual wireless base station includes a plurality of virtual baseband modules, a plurality of interface/router modules, an orchestrator module and a fabric mapper module. Each of the plurality of virtual baseband modules is coupled to the interface/router modules by a low latency switch fabric. The orchestrator determines current and near future demand for connectivity within the virtual wireless base station and either instantiates and connects new virtual baseband processors to meet a rise in demand, or shuts down underutilized virtual baseband processors in case of insufficient demand.

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

Abstract: A clamping mechanism (30) for clamping a flexible tube comprises two rotatable bobbins (22, 32), each with a tube-engaging surface portion (24) defining boundaries of: a free space through which a tube may extend. The shape of: the tube-engaging surface portion (24) changes around the bobbin circumference, such that axial rotation of the bobbins (22, 32) reduces the free space and thereby squeezes the tube. This allows the flow through the tube to be altered dependent on the rotation of: the bobbins.

Abstract: Methods and systems for single molecule sequencing using concatemers of copies of sense and antisense strands. Concatemers are provided, for example, by carrying out rolling circle amplification on a circular molecule having sense and antisense regions to produce repeated copies of the sense and antisense regions connected by linking regions. The circular molecules can be produced by ligating hairpin adapters to each end of a double-stranded nucleic acid having a sense and antisense strand. The ligations can be carried out, for example using blunt end ligation. In some cases, a single molecule consensus sequence for a single template molecule is obtained. A single read from each template molecule can be obtained by comparing the sequence information of the sense and antisense regions.