Abstract: A clamping mechanism (30) for clamping a flexible tube comprises two rotatable bobbins (22, 32), each with a tube-engaging surface portion (24) defining boundaries of: a free space through which a tube may extend. The shape of: the tube-engaging surface portion (24) changes around the bobbin circumference, such that axial rotation of the bobbins (22, 32) reduces the free space and thereby squeezes the tube. This allows the flow through the tube to be altered dependent on the rotation of: the bobbins.

Abstract: Methods and systems for single molecule sequencing using concatemers of copies of sense and antisense strands. Concatemers are provided, for example, by carrying out rolling circle amplification on a circular molecule having sense and antisense regions to produce repeated copies of the sense and antisense regions connected by linking regions. The circular molecules can be produced by ligating hairpin adapters to each end of a double-stranded nucleic acid having a sense and antisense strand. The ligations can be carried out, for example using blunt end ligation. In some cases, a single molecule consensus sequence for a single template molecule is obtained. A single read from each template molecule can be obtained by comparing the sequence information of the sense and antisense regions.

Abstract: An oxygenator (10) for an extracorporeal ventilation system comprises a gas passage and a blood passage arranged to allow gas exchange of an oxygenation gas supply with blood via a gas-blood interface (34). The gas passage leads from a gas inlet zone (28) via the gas-blood interface (34) to a gas exhaust zone (40). The blood passage leads from a blood inlet (12) via the gas-blood interface (34) to a blood outlet (14). The oxygenator comprises a supply gas distribution arrangement (26, 28A, 28B). This allows the oxygenation gas supply to be modulated differently for different interface regions of the gas-blood interface. The oxygenator can be used to remove or reduce the formation of gaseous microemboli bubbles.

Abstract: Disclosed is a system and methods for creating and maintaining a virtual subnetwork of telecommunication base stations within a wider telecommunication network. In an LTE-based example, the subnetwork includes a connection aggregator that is coupled between the plurality of eNodeBs internal to the subnetwork and one or more MMEs in the outer network. The connection aggregator intercepts all control plane messages between the MMEs and the internal eNodeBs, remaps eNodeB identifiers, and transmits repackaged messages so that the outer network sees the entire subnetwork as a single “giant” eNodeB. The disclosed system and methods enables the operator of the virtual subnetwork to add and shut down eNodeBs as demand for connectivity fluctuates, and to do so such that all changes are unseen by the outer network.

Abstract: Disclosed is a system and methods for creating and maintaining a virtual subnetwork of telecommunication base stations within a wider telecommunication network. In an LTE-based example, the subnetwork includes a connection aggregator that is coupled between the plurality of eNodeBs internal to the subnetwork and one or more MMEs in the outer network. The connection aggregator intercepts all control plane messages between the MMEs and the internal eNodeBs, remaps eNodeB identifiers, and transmits repackaged messages so that the outer network sees the entire subnetwork as a single “giant” eNodeB. The disclosed system and methods enables the operator of the virtual subnetwork to add and shut down eNodeBs as demand for connectivity fluctuates, and to do so such that all changes are unseen by the outer network.

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: A method of controlling thermal transfer in a perfusion system heat exchanger of an extracorporeal fluid treatment device for conditioning an extracorporeal patient fluid for administration to a patient comprises a step of providing a perfusion system heat exchanger, wherein the perfusion system heat exchanger comprises a first fluid passage for a liquid heat transfer medium and a second fluid passage for the extracorporeal patient fluid to be temperature-controlled via exchange of thermal energy with the heat transfer medium, and a step of providing the heat transfer medium through the first fluid passage. The heat transfer medium comprises a component with anti-microbial properties, such as glycol. The provision of antimicrobial fluid reduces the risk of microbe contamination of the extracorporeal fluid, and hence the risk of clinical complications.

Abstract: The disclosure relates to detecting vulnerabilities in managed client devices. A system determines whether a vulnerability scan of a computing device is required to be performed. The system installs a vulnerability detection component in the computing device in response to determining that the vulnerability scan is required to be performed. The system requests the vulnerability detection component to perform the vulnerability scan of the computing device. The system transmits a result of the vulnerability scan to a remote management service for the computing device.

Abstract: A wireless telecommunications base station that compensates for Doppler shift in each connected User Equipment. The base station deploys a plurality of parallel receivers, each with a given frequency offset above and below the carrier frequency. Each receiver performs a frequency shift on a common uplink signal, determines the quality of the frequency shifted uplink signal, and demodulates the frequency shifted uplink signal. A selector/combiner module generates a highest quality demodulated signal, which may be done by selecting the frequency shifted uplink signal or soft combining a subset of frequency shifted uplink signals having a sufficiently high quality.

Abstract: A 5G gNodeB has a Centralized Unit (CU) and one or more Distributed Units (DU). Each of the one or more DUs has a cell topology information that it sends to the CU so that the CU has information for each DU for each of the DU's cells, including which cells are available to each primary cell for carrier aggregation. When a UE connects to the CU, the CU queries its configuration information—including cell topology information for the DU connected to the UE— to determine if and which secondary cells are available for carrier aggregation. If so, the CU may signal the DU to configure and subsequently activate the one or more secondary cells to which the UE can connect for carrier aggregation.

Abstract: A wireless telecommunications base station that compensates for Doppler shift in each connected User Equipment. The base station deploys a plurality of parallel receivers, each with a given frequency offset above and below the carrier frequency. Each receiver performs a frequency shift on a common uplink signal, determines the quality of the frequency shifted uplink signal, and demodulates the frequency shifted uplink signal. A selector/combiner module generates a highest quality demodulated signal, which may be done by selecting the frequency shifted uplink signal or soft combining a subset of frequency shifted uplink signals having a sufficiently high quality.

Abstract: A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.

Abstract: Disclosed is a virtual base station capable of hosting multiple network operators and/or private networks in a single compute environment. The virtual base station includes a plurality of virtual baseband processors configured to communicate with the plurality of mobile network operators, a supervisor module, a fronthaul network interface configured to be coupled to one or more remote units, and a KPI (Key Performance Indicator) coordinator module coupled to the supervisor module and the one or more virtual baseband processors. The base station may have on or more CBRS (Citizens Broadband Radio Service) Daemons to act as a proxy for obtaining grants to CBRS channels and allocating the CBRS channels to the mobile network operators.

Abstract: Disclosed is a virtual wireless base station that can dynamically scale its capacity to meet changes in demand for connectivity. The virtual wireless base station includes a plurality of virtual baseband modules, a plurality of interface/router modules, an orchestrator module and a fabric mapper module. Each of the plurality of virtual baseband modules is coupled to the interface/router modules by a low latency switch fabric. The orchestrator determines current and near future demand for connectivity within the virtual wireless base station and either instantiates and connects new virtual baseband processors to meet a rise in demand, or shuts down underutilized virtual baseband processors in case of insufficient demand.

Abstract: An exchanger for medical use comprises: a box-like body having a base, an upper end, a peripheral wall that delimits a heat exchange chamber; the body having: a first aperture from which a fluid to be thermo-regulated enters and a first exit of the thermo-regulated fluid; a second delivery aperture of a thermo-regulator fluid and a second exit of the thermo-regulated fluid; a heat exchange element that exchanges heat by lapping, housed in the exchange chamber and held between two holding elements, dividing the exchange chamber into a zone where the thermo-regulator fluid flows and a zone where the fluid to be thermo-regulated flows, which are fluid-dynamically separated from each other; a collection compartment to collect the air separated from the fluid to be thermo-regulated, obtained in the opposite end, connected to the thermo-regulation chamber and equipped with an aperture toward the outside; the box-like body has a second housing chamber for a pumping group, connected with the heat exchange chamber.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: Disclosed are various examples that relate to adjusting a stringency of offline policy restrictions based on a situational context of a computing device. In one example, a system can receive an offline restriction policy for an application. The system can identify a request to execute an application during the offline period of time. A situational context of the computing device can be determined. A first application restriction can be enforced for the application on the computing device based on the identification of the computing device being in the offline period of time and the situational context. A change in the situational context of the computing device can be identified during the offline period of time based on a detection of a second condition. A second application restriction can be enforced for the application on the computing device during the offline period of time.

Abstract: Disclosed is a virtual base station capable of hosting multiple network operators and/or private networks in a single compute environment. The virtual base station includes a plurality of virtual baseband processors configured to communicate with the plurality of mobile network operators, a supervisor module, a fronthaul network interface configured to be coupled to one or more remote units, and a KPI (Key Performance Indicator) coordinator module coupled to the supervisor module and the one or more virtual baseband processors. The base station may have on or more CBRS (Citizens Broadband Radio Service) Daemons to act as a proxy for obtaining grants to CBRS channels and allocating the CBRS channels to the mobile network operators.