Abstract: Disclosed is a virtual base station capable of hosting multiple network operators and/or private networks in a single compute environment. The virtual base station includes a plurality of virtual baseband processors configured to communicate with the plurality of mobile network operators, a supervisor module, a fronthaul network interface configured to be coupled to one or more remote units, and a KPI (Key Performance Indicator) coordinator module coupled to the supervisor module and the one or more virtual baseband processors. The base station may have on or more CBRS (Citizens Broadband Radio Service) Daemons to act as a proxy for obtaining grants to CBRS channels and allocating the CBRS channels to the mobile network operators.

Abstract: The present invention provides methods, compositions, and systems for distributing single polymerase molecules into array regions. In particular, the methods, compositions, and systems of the present invention result in a distribution of single polymerase molecules into array regions at a percentage that is larger than the percentage expected to be occupied under a Poisson distribution.

Abstract: Disclosed are various examples for Internet of Things (IoT) device discovery and deployment. In some embodiments, a device identifier is received from an IoT device. The IoT device is determined, based on the device identifier, to be associated with a device account with a management service. An enrollment of the IoT device is performed. A capabilities declaration is received from the IoT device. IoT device instructions are determined based on the capabilities declaration. IoT device instructions are transmitted to the IoT device, causing it to perform a capability specified in the capabilities declaration.

Abstract: Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations.

Abstract: A flow control system of a clinical perfusion system comprises flow control devices 110, such as pumps, valves and/or clamps, capable of controlling a fluid flow rate according to flow rate parameters from the flow control system. The flow control system comprises an indicator arrangement including a device indicator 122a, 122b on each flow control device 110 capable of providing a plurality of indications. The device indicators 122a, 122b are controllable by the flow control system to indicate an active condition of the flow control device 110 independently of the flow rate parameters. This allows the indication provided by the device indicator 122a, 122b to be adjusted for different clinical environments, and to provide colour indications that match the colour range discernible by users affected by colour vision deficiency.

Abstract: Provided are pixels, devices, systems, and methods relating to active pixel sensor in which each active pixel puts out a signal that represents a temporal differential. The output of the active pixel represents a comparison or difference between successive frames. The differential can represent the state of the sensor element in the pixel at the end of one frame compared to the state of the sensor element of the frame, at the end of the prior frame.

Abstract: Disclosed is a mobile edge computing system that provides localized emergency responses and warning exclusively to UEs within a venue or area, and provides location-specific warning within the venue or area. The system includes a component that aggregates the S1-mme interface between the MME and a plurality of baseband units and provides read and write access to the S1-mme interface. The disclosed mobile edge computing system can issue cell-specific public warning system (PWS) messages that are customized for and transmitted exclusively to each individual cell within the venue.

Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.

Abstract: The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites. In particular, the methods, compositions, and systems of the present invention result in an active loading of molecules and complexes into reaction sites with improved efficiency over loading by passive diffusion methods alone.

Abstract: A blood gas analysis method (100) is provided for determining the partial pressure of oxygen of arterial blood exiting an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to an oxygenation gas and releases excess oxygenation gas as exhaust gas. The method (100) comprises a step (140) of determining an estimate of the partial pressure of oxygen in the exhaust gas, a step (150) of determining the blood oxygen uptake in the oxygenator, and a step (160) of determining the partial pressure of oxygen in the arterial blood by adjusting the estimate using the blood oxygen uptake value. Used in a clinical setting, the method (100) allows a more accurate output of the partial pressure of oxygen in the arterial blood to be provided, which facilitates oxygenator operation.

Abstract: A gas supply control system for an oxygenator of an extracorporeal ventilation system is configured for connection to external gas supply ports for oxygen and nitrogen in the form of air and to create a supply gas output from oxygen and nitrogen. The gas supply control system comprises two or more gas output lines and configured to supply the two or more gas output lines with the supply gas output. The flow rates through the gas output lines may be modulated differently.

Abstract: Disclosed is a system and methods for creating and maintaining a virtual subnetwork of telecommunication base stations within a wider telecommunication network. In an LTE-based example, the subnetwork includes a connection aggregator that is coupled between the plurality of eNodeBs internal to the subnetwork and one or more MMEs in the outer network. The connection aggregator intercepts all control plane messages between the MMEs and the internal eNodeBs, remaps eNodeB identifiers, and transmits repackaged messages so that the outer network sees the entire subnetwork as a single “giant” eNodeB. The disclosed system and methods enables the operator of the virtual subnetwork to add and shut down eNodeBs as demand for connectivity fluctuates, and to do so such that all changes are unseen by the outer network.

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

Abstract: A control system controlling the line pressure in a blood supply system (1) in which a pump (14) pumps blood from a reservoir (10) via a primary passage (18) toward a plurality of outlets (16, 26, 26a), wherein one or more outlets are openable to permit flow and closable to block flow, said control system comprises a monitoring arrangement to determine a line pressure in the primary passage, and a controller responsive to the monitoring arrangement and controlling the pump (14) to maintain the line pressure in the primary passage (18) above a pre-set level. The control system practically eliminates the risk of a momentary reduction in blood supply line pressure when an outlet is opened.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: A clamp arrangement for retaining a flexible tube (18) during operation of a roller pump (10) for pumping fluid, the clamp arrangement comprising a pair of rotatable bobbins (24A, 24B, 26A, 26B) mounted adjacent to each other. Each bobbin (24A, 24B, 26A, 26B) has a tapered groove (30), formed partially around a cylindrical surface of the bobbin (24A, 24B, 26A, 26B), and counter rotation of the bobbins (24A, 24B, 26A, 26B) clamps the tube 18 between the bobbins (24A, 24B, 26A, 26B) in the tapered grooves (30). The clamp arrangement allows tubes of different shapes and diameters to be securely held without overly deforming the tube.

Abstract: An exchanger for medical use comprises: a box-like body having a base, an upper end, a peripheral wall that delimits a heat exchange chamber; the body having: a first aperture from which a fluid to be thermo-regulated enters and a first exit of the thermo-regulated fluid; a second delivery aperture of a thermo-regulator fluid and a second exit of the thermo-regulated fluid; a heat exchange element that exchanges heat by lapping, housed in the exchange chamber and held between two holding elements, dividing the exchange chamber into a zone where the thermo-regulator fluid flows and a zone where the fluid to be thermo-regulated flows, which are fluid-dynamically separated from each other; a collection compartment to collect the air separated from the fluid to be thermo-regulated, obtained in the opposite end, connected to the thermo-regulation chamber and equipped with an aperture toward the outside; the box-like body has a second housing chamber for a pumping group, connected with the heat exchange chamber.

Abstract: Disclosed is a system and methods for creating and maintaining a virtual subnetwork of telecommunication base stations within a wider telecommunication network. In an LTE-based example, the subnetwork includes a connection aggregator that is coupled between the plurality of eNodeBs internal to the subnetwork and one or more MMEs in the outer network. The connection aggregator intercepts all control plane messages between the MMEs and the internal eNodeBs, remaps eNodeB identifiers, and transmits repackaged messages so that the outer network sees the entire subnetwork as a single “giant” eNodeB. The disclosed system and methods enables the operator of the virtual subnetwork to add and shut down eNodeBs as demand for connectivity fluctuates, and to do so such that all changes are unseen by the outer network.

Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.