Patents by Inventor Stephen Wang

Stephen Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250146038
    Abstract: The present disclosure relates generally to methods of generating functional self-replicating RNAs from non-functional positive-sense single-stranded RNA (+ssRNA) virus genomes such as alphavirus genomes or srRNAs. More particularly, the methods pertain to the assembly of a plurality of nucleic acid fragments to generate de novo functional srRNAs. Also provided are compositions, nucleic acid constructs, vectors and recombinant cells including such functional srRNAs. Further disclosed herein are methods for inducing a pharmacodynamic effect in a subject as well as methods for preventing and/or treating a health condition in a subject in need thereof.
    Type: Application
    Filed: January 27, 2023
    Publication date: May 8, 2025
    Inventors: Nathaniel Stephen Wang, Shigeki Joseph MIYAKE-STONER
  • Publication number: 20250076954
    Abstract: Hierarchical Power Management (HPM) architecture considers the limits of scaling on a power management controller, the autonomy at each die, and provides a unified view of the package to a platform. At a simplest level, HPM architecture has a supervisor and one or more supervisee power management units (PMUs) that communicate via at least two different communication fabrics. Each PMU can behave as a supervisor for a number of supervisee PMUs in a particular domain. HPM addresses these needs for products that comprise a collection of dice with varying levels of power and thermal management capabilities and needs. HPM serves as a unified mechanism than can span collection of dice of varying capability and function, which together form a traditional system-on-chip (SoC). HPM provides a basis for managing power and thermals across a diverse set of dice.
    Type: Application
    Filed: September 12, 2024
    Publication date: March 6, 2025
    Inventors: Vivek GARG, Ankush VARMA, Krishnakanth SISTLA, Nikhil GUPTA, Nikethan Shivanand BALIGAR, Stephen WANG, Nilanjan PALIT, Timothy Yee-Kwong KAM, Adwait PURANDARE, Ujjwal GUPTA, Stanley CHEN, Dorit SHAPIRA, Shruthi VENUGOPAL, Suresh CHEMUDUPATI, Rupal PARIKH, Eric DEHAEMER, Pavithra SAMPATH, Phani Kumar KANDULA, Yogesh BANSAL, Dean MULLA, Michael TULANOWSKI, Stephen Paul HAAKE, Andrew HERDRICH, Ripan DAS, Nazar Syed HAIDER, Aman SEWANI
  • Publication number: 20250027109
    Abstract: The present disclosure relates to the field of molecular virology, and particularly relates to nucleic acid molecules encoding a modified alphavirus virus viral genome or self-replicating RNA (srRNA) construct, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting a pharmacodynamics effect in a subject.
    Type: Application
    Filed: November 28, 2022
    Publication date: January 23, 2025
    Inventors: Nathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER, Parinaz ALIAHMAD
  • Publication number: 20250027110
    Abstract: The present disclosure relates to the field of molecular virology, and particularly relates to nucleic acid molecules encoding a modified equine encephalitis virus viral genome or self-replicating RNA (srRNA) construct, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating cancer.
    Type: Application
    Filed: November 28, 2022
    Publication date: January 23, 2025
    Inventors: Nathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER, Parinaz ALIAHMAD
  • Publication number: 20250019745
    Abstract: The present disclosure generally relates to new processes for generating self-replicating RNA (srRNA) systems with superior expression properties. The disclosure also provides nucleic acids and recombinant cells expressing such srRNA constructs as well as pharmaceutical compositions containing the same. Further provided are compositions and methods for inducing pharmacodynamic effects in a subject and for the prevention and/or treatment of various health conditions.
    Type: Application
    Filed: November 28, 2022
    Publication date: January 16, 2025
    Inventors: Nathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER, Parinaz ALIAHMAD
  • Publication number: 20240400619
    Abstract: The present disclosure relates to the field of molecular virology, including nucleic acid molecules comprising modified viral genomes or replicons (e.g., self-replicating RNAs), pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating various health conditions.
    Type: Application
    Filed: September 1, 2022
    Publication date: December 5, 2024
    Inventors: Nathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER
  • Publication number: 20240349125
    Abstract: A device may determine whether to utilize perfect channel state information at transmitter (CSIT) or imperfect CSIT, and may calculate, based on determining to utilize the perfect CSIT, a first power allocation, a first rate allocation, and a first precoder allocation for a private stream of a user device. The device may determine first parameters or second parameters for the first power allocation, the first rate allocation, and the first precoder allocation, and may generate a first transmit signal and a first data allocation based on the first power allocation, the first rate allocation, the first precoder allocation, and the first parameters or the second parameters. The device may provide the first transmit signal, with the first data allocation, to the user device via the private stream.
    Type: Application
    Filed: April 12, 2023
    Publication date: October 17, 2024
    Inventors: Onur DIZDAR, Ata SATTARZADEH HASHEMI, Yi Xien YAP, Stephen WANG
  • Publication number: 20240327865
    Abstract: The present disclosure relates to the field of molecular virology, including nucleic acid molecules comprising modified viral genomes or replicons (e.g., self-replicating RNAs), pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating various health conditions.
    Type: Application
    Filed: July 8, 2022
    Publication date: October 3, 2024
    Inventors: Nathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER, Parinaz ALIAHMAD
  • Patent number: 12093100
    Abstract: Hierarchical Power Management (HPM) architecture considers the limits of scaling on a power management controller, the autonomy at each die, and provides a unified view of the package to a platform. At a simplest level, HPM architecture has a supervisor and one or more supervisee power management units (PMUs) that communicate via at least two different communication fabrics. Each PMU can behave as a supervisor for a number of supervisee PMUs in a particular domain. HPM addresses these needs for products that comprise a collection of dice with varying levels of power and thermal management capabilities and needs. HPM serves as a unified mechanism than can span collection of dice of varying capability and function, which together form a traditional system-on-chip (SoC). HPM provides a basis for managing power and thermals across a diverse set of dice.
    Type: Grant
    Filed: September 26, 2020
    Date of Patent: September 17, 2024
    Assignee: Intel Corporation
    Inventors: Vivek Garg, Ankush Varma, Krishnakanth Sistla, Nikhil Gupta, Nikethan Shivanand Baligar, Stephen Wang, Nilanjan Palit, Timothy Yee-Kwong Kam, Adwait Purandare, Ujjwal Gupta, Stanley Chen, Dorit Shapira, Shruthi Venugopal, Suresh Chemudupati, Rupal Parikh, Eric Dehaemer, Pavithra Sampath, Phani Kumar Kandula, Yogesh Bansal, Dean Mulla, Michael Tulanowski, Stephen Paul Haake, Andrew Herdrich, Ripan Das, Nazar Syed Haider, Aman Sewani
  • Publication number: 20240218395
    Abstract: The present disclosure relates to the field of molecular virology, including nucleic acid molecules comprising modified viral genomes or replicons (e.g., self-replicating RNAs), pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for modulating an immune response in a subject in need thereof, as well as methods for preventing and/or treating various health conditions.
    Type: Application
    Filed: April 20, 2022
    Publication date: July 4, 2024
    Inventors: Nathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER, Annie Chia-Zong CHOU
  • Publication number: 20240209379
    Abstract: The present disclosure generally relates to nucleic acid molecules for use in regulating gene expression. Disclosed herein include nucleic acid molecules containing one or more structural elements of the viral capsid enhancer operably linked to a coding sequence of a gene of interest. In some embodiments, the viral capsid enhancer comprises a Downstream Loop (DLP) from a viral capsid protein, or a variant of the DLP.
    Type: Application
    Filed: October 31, 2023
    Publication date: June 27, 2024
    Inventors: Kurt Iver KAMRUD, Maung Nyan WIN, Nathaniel Stephen WANG, Jason L. DEHART
  • Publication number: 20240183727
    Abstract: Disclosed is a tactile sensing device, including a light source, a plurality of optical waveguides, photoelectric sensing components, and a contact point. The light source is disposed at an input end of each optical waveguide, and the photoelectric sensing component is disposed at an output end of each optical waveguide. The plurality of optical waveguides surround the contact point, and the contact point is in contact with each optical waveguide. When there is a contact force at the contact point, the plurality of optical waveguides are deformed, and deformations of the optical waveguides cause losses of optical signals transmitted in the optical waveguides. The photoelectric sensing component obtains an optical signal transmitted by each optical waveguide, and may detect a value and a direction of the contact force based on a variation of the optical signal transmitted by each optical waveguide.
    Type: Application
    Filed: February 9, 2024
    Publication date: June 6, 2024
    Inventors: Stephen WANG, Hongbin LIU, Jian HU, Danqian CAO, Gang NI, Tao HUANG
  • Publication number: 20240075379
    Abstract: A game server provides game data of a location-based game to a plurality of client devices based on a first set of one or more game designs. First activity data associated with the location-based game is received from the plurality of client devices based on the first set of one or more game designs. The game server determines whether the first activity data from the plurality of client devices meets a predetermined starting condition associated with a local virtual event. The local virtual event is started for the plurality of client devices in response to determining that the first activity data meets the predetermined starting condition. The game server provides game data based on the local virtual event to the plurality of client devices. The virtual event has a second game design that is different from the first set of one or more game designs.
    Type: Application
    Filed: September 6, 2022
    Publication date: March 7, 2024
    Inventors: Tim Aldridge, Gordon Paul Jeffery, III, Stephen Wang
  • Publication number: 20240042005
    Abstract: The present disclosure generally relates to the use of different self-amplifying RNA molecules to enhance immune responses, for example immune responses following prophylactic vaccination or therapeutic administration. Some embodiments relate to compositions and methods for inducing an immune response in a subject using prime-boost immunization regimens.
    Type: Application
    Filed: October 23, 2023
    Publication date: February 8, 2024
    Inventors: Kurt Iver KAMRUD, Nathaniel Stephen WANG, Parinaz ALIAHMAD, Jason L. DEHART
  • Patent number: 11873507
    Abstract: The present disclosure relates to the field of molecular virology, and particularly relates to nucleic acid molecules encoding a modified alphavirus virus viral genome or self-replicating RNA (srRNA) construct, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting a pharmacodynamics effect in a subject.
    Type: Grant
    Filed: November 29, 2021
    Date of Patent: January 16, 2024
    Assignee: Replicate Bioscience, Inc.
    Inventors: Nathaniel Stephen Wang, Shigeki Joseph Miyake-Stoner, Parinaz Aliahmad
  • Patent number: 11845939
    Abstract: The present disclosure generally relates to nucleic acid molecules for use in regulating gene expression. Disclosed herein include nucleic acid molecules containing one or more structural elements of the viral capsid enhancer operably linked to a coding sequence of a gene of interest. In some embodiments, the viral capsid enhancer comprises a Downstream Loop (DLP) from a viral capsid protein, or a variant of the DLP.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: December 19, 2023
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Kurt Iver Kamrud, Maung Nyan Win, Nathaniel Stephen Wang, Jason L. DeHart
  • Publication number: 20230398200
    Abstract: The present disclosure relates to the field of molecular virology, including nucleic acid molecules comprising modified viral genomes or replicons, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating various health conditions.
    Type: Application
    Filed: July 30, 2021
    Publication date: December 14, 2023
    Inventors: Nathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER
  • Publication number: 20230403047
    Abstract: This application provides an antenna apparatus and a communication method. The antenna apparatus includes a processing module and a plurality of transmission links. The processing module is configured to generate a to-be-transmitted signal, and transmit the to-be-transmitted signal to the plurality of transmission links. The plurality of transmission links are configured to transmit the to-be-transmitted signal. The plurality of transmission links include at least one electric near field transmission link and at least one magnetic near field transmission link. The electric near field transmission link includes an electric near field front end and an electric near field antenna. The electric near field front end is configured to transmit the to-be-transmitted signal to the electric near field antenna. The magnetic near field transmission link includes a magnetic near field front end and a magnetic near field antenna.
    Type: Application
    Filed: August 25, 2023
    Publication date: December 14, 2023
    Inventors: Stephen WANG, Yongjun LIU, Liang YANG
  • Patent number: 11826416
    Abstract: The present disclosure generally relates to the use of different self-amplifying RNA molecules to enhance immune responses, for example immune responses following prophylactic vaccination or therapeutic administration. Some embodiments relate to compositions and methods for inducing an immune response in a subject using prime-boost immunization regimens.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: November 28, 2023
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Kurt Iver Kamrud, Nathaniel Stephen Wang, Parinaz Aliahmad, Jason L. Dehart
  • Patent number: 11730804
    Abstract: The present disclosure relates generally to the field of molecular virology, and particularly relates to nucleic acid molecules encoding a modified alphavirus virus viral genome or self-replicating RNA (srRNA) construct, recombinant cells and pharmaceutical compositions containing the same, as well as the use of such nucleic acid molecules, recombinant cells and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating rabies virus infection.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: August 22, 2023
    Assignee: Replicate Bioscience, Inc.
    Inventors: Nathaniel Stephen Wang, Shigeki Joseph Miyake-Stoner, Parinaz Aliahmad, Andrew Geall