Abstract: The present disclosure relates to improved biomanufacturing systems and methods with an ability to effectively control process variability to consistently generate high-quality cell-based therapies. In particular, disclosed herein is a using model-based control for determining process parameters in a bioreactor in real time. Additionally disclosed herein is a system for generating an AI digital twin model for a commercial-scale bioreactor.

Abstract: The present disclosure relates generally to methods of generating functional self-replicating RNAs from non-functional positive-sense single-stranded RNA (+ssRNA) virus genomes such as alphavirus genomes or srRNAs. More particularly, the methods pertain to the assembly of a plurality of nucleic acid fragments to generate de novo functional srRNAs. Also provided are compositions, nucleic acid constructs, vectors and recombinant cells including such functional srRNAs. Further disclosed herein are methods for inducing a pharmacodynamic effect in a subject as well as methods for preventing and/or treating a health condition in a subject in need thereof.

Abstract: Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.

Abstract: The present technology relates to depots for the treatment of postoperative pain via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.

Abstract: An automated sampling platform includes a gantry-style 2D or 3D actuator equipped with a syringe pump end effector configured to extract samples from a rubber septum placed in-line within a tubing-based system and to deposit the extracted samples into sealed cryovials for storage. This device can be employed for use in cell culture bioreactors, such as the Terumo Quantum, which include a waste line.

Abstract: A classification model is generated based on historical exercise information. User exercise information is classified into an exercise category using the classification model. Recommendations based on the exercise category is identified. A customized exercise recommendation is determined from the identified recommendations based on a comparison of the user exercise information and expected progress data. This customized recommendation is provided to a user device for consumption.

Abstract: Methods and apparatus for changing cell range coverage are disclosed. A wireless transmit/receive unit (WTRU) may include circuitry configured to transmit subframes of radio frames using a physical uplink shared channel (PUSCH), where the subframes are divided into first and second sets. The circuitry may include a first power control loop utilized for the first set of subframes and a second power control loop utilized for the second set of subframes. The first power control loop may set transmission power levels for transmission over the PUSCH for the first set of subframes, and the second power control loop may set transmission power levels for transmission over the PUSCH for the second set of subframes. The circuitry may be configured with a first physical uplink control channel (PUCCH) for a first eNodeB and a second PUCCH for a second eNodeB to simultaneously communicate with the first and the second eNodeBs.

Abstract: Techniques for handling natural language query processing are described. In some examples, a sequence-to-sequence model is used to handle a natural language query. Post-processing of a result of the sequence-to-sequence model utilizes fine-grained information from an entity linker. In some examples, the sequence-to-sequence model and aspects of a natural language query pipeline are used to handle a natural language query.

Abstract: An IV catheter system may have a catheter component with a catheter hub, a cannula extending distally from the catheter hub, and a push feature protruding outwardly from the catheter hub. The IV catheter system may also have a needle component with a needle hub, a needle extending distally from the needle hub along an axis, and a grip extending from the needle hub, generally parallel to the axis, with a pull feature. In the insertion configuration, the needle may be positioned within the cannula and the distal end of the needle hub may be seated in a needle port of the catheter hub. In the fluid delivery configuration, the needle may be positioned outside the catheter hub. The push and pull features may be positioned to facilitate manipulation with a single hand to move the IV catheter system from an insertion configuration to a fluid delivery configuration.

Abstract: Techniques are described for invoking and switching between chatbots of a chatbot system. In some embodiments, the chatbot system is capable of routing an utterance received while a user is already interacting with a first chatbot in the chatbot system. For instance, the chatbot system may identify a second chatbot based on determining that (i) such an utterance is an invalid input to the first chatbot or (ii) that the first chatbot is attempting to route the utterance to a destination associated with the first chatbot. Identifying the second chatbot can involve computing, using a predictive model, separate confidence scores for the first chatbot and the second chatbot, and then determining that a confidence score for the second chatbot satisfies one or more confidence score thresholds. The utterance is then routed to the second chatbot based on the identifying of the second chatbot.

Abstract: This disclosure relates to synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E, methods of making such peptides, peptidomimetics, and complexes, and methods of using such peptides, peptidomimetics and complexes for blocking, inhibiting, or preventing the interaction of HLA-E with CD94/NKG2A or activation of CD94/NKG2A by HLA-E. The synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E can further comprise warheads to introduce covalent linkages between the synthetic peptides and peptidomimetics with HLA-E.

Abstract: System and methods for continuous culture comprise performing a first continuous culture of cells in a chamber of a first bioreactor under culture conditions that produce cell growth; moving culture fluid comprising cells from the chamber of the first bioreactor into a chamber of a second bioreactor though one or more fluidic conduits; and performing, in the chamber of the second bioreactor, a second continuous culture of cells under culture conditions that produce at least one culture product. The process is performed under conditions wherein the rate of cell growth in the first continuous culture is greater than that of the second continuous culture, and the production of culture product in the first continuous culture is less than that of the second continuous culture.

Abstract: The present disclosure describes ethylene/?-olefin copolymer products with a density from 0.865 to 0.905 g/cm3 characterized as having unique rheological fingerprint during their transition from a solid state into a fully molten state. The ethylene/?-olefin copolymer products comprise a first high-density fraction and optionally a second high-density fraction. wherein said first and said optional second high-density fractions have distinct chemical compositions from that of the overall ethylene/?-olefin copolymer products. The first high-density fraction further has a weight-average molecular weight Mw,1HD, wherein Mw,1HD and the weight average molecular weight of the overall ethylene/?-olefin copolymer product Mw satisfy the inequality of Mw,1HD/Mw>2.

Abstract: A mobile device or a method performed by a mobile device for protecting user privacies by swapping IMEI values. The mobile device accesses an IMEI value stored by and corresponding to the mobile device, selects a managed IMEI value from a pool of candidate IMEI values, and replaces the IMEI value with the managed IMEI value. In response to receiving an IMEI request from a wireless entity, the mobile device provides the managed IMEI value to the wireless entity. In response to receiving an IMEI request from an authentication service, the mobile device provides the IMEI value corresponding to the mobile device to the authentication service.

Abstract: A method for downhole event detection includes measuring a parameter of a wellbore using a first sensor of a drill string, and measuring the parameter of the wellbore using a second sensor of the drill string. The method also includes detecting, by surface equipment, an event in the wellbore based on a first set of measurements provided by the first sensor, and detecting, by the surface equipment, the event in the wellbore based on a second set of measurements provided by the second sensor. The method further includes assigning, by the surface equipment, a probability value to the event based on the event as detected in the first set of measurement values and the event as detected in the second set of measurement values.

Abstract: A craft capable of a vertical take-off and landing configuration and a horizontal thrust configuration may include, for example, at least a proprotor, an edgewise blade, and a body. The proprotor may be configured to tilt to achieve a horizontal thrust component. A portion of a lift surface may be configured to tilt with the proprotor. In some embodiments, the vertical take-off and/or landing craft may further comprise a tail connected to a first boom and a second boom. In some embodiments, the vertical take-off and/or landing craft may further comprise a tail attached to the body.

Abstract: Hierarchical Power Management (HPM) architecture considers the limits of scaling on a power management controller, the autonomy at each die, and provides a unified view of the package to a platform. At a simplest level, HPM architecture has a supervisor and one or more supervisee power management units (PMUs) that communicate via at least two different communication fabrics. Each PMU can behave as a supervisor for a number of supervisee PMUs in a particular domain. HPM addresses these needs for products that comprise a collection of dice with varying levels of power and thermal management capabilities and needs. HPM serves as a unified mechanism than can span collection of dice of varying capability and function, which together form a traditional system-on-chip (SoC). HPM provides a basis for managing power and thermals across a diverse set of dice.

Abstract: Provided are systems, apparatuses, and techniques for managing processor system power and performance based on operational metrics, hardware capabilities, and/or other parameters.

Abstract: The present disclosure relates to the treatment of cancer and/or cancer-associated disease. Certain aspects relate to the treatment of an individual having cancer or cancer-associated disease by administering to the individual a combination therapy of a first therapeutic agent that is an EZH2 inhibitor, a second therapeutic agent that is a CDK inhibitor, and a third therapeutic agent that is a selective estrogen receptor degrader.

Abstract: A vehicle proximity and alert system and apparatus warns snowmobilers of other approaching vehicles with potential risk of collision. To better prevent accidents, the system calculates collision risks and warns the rider based on level of risk. When riding in groups, a member can press a stop request button to ask the group to slow down. When a member exits the group, everyone in the group will receive a message, alerts or indication with the update. The vehicle detection system utilizes Bluetooth low energy (BLE), LoRa technologies and/or global positioning system technologies and is designed to detect other devices in the region and use acquired information to calculate proximity and risk of collision.