Abstract: The present disclosure generally relates to viral-based expression systems suitable for the production of molecule of interests in recombinant host cells. The disclosure particularly relates to nucleic acid constructs, such as expression vectors, containing a modified arterivirus genome or replicon RNA in which at least some of its original viral sequence has been deleted. Also included in the disclosure are viral-based expression vectors including one or more expression cassettes encoding heterologous polypeptides. In some embodiments, the expression cassettes are configured and positioned at defined locations on the viral genome so as to enable expression of the heterologous polypeptides in a tunable manner.

Abstract: The present disclosure relates to the field of molecular virology, and particularly relates to nucleic acid molecules encoding a modified alphavirus virus viral genome or self-replicating RNA (srRNA) construct, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting a pharmacodynamics effect in a subject.

Abstract: The present disclosure generally relates to viral-based expression systems suitable for the production of molecule of interests in recombinant host cells. The disclosure particularly relates to nucleic acid constructs, such as expression vectors, containing a modified arterivirus genome or replicon RNA in which at least some of its original viral sequence has been deleted. Also included in the disclosure are viral-based expression vectors including one or more expression cassettes encoding heterologous polypeptides. In some embodiments, the expression cassettes are configured and positioned at defined locations on the viral genome so as to enable expression of the heterologous polypeptides in a tunable manner.

Abstract: The present disclosure relates to the field of molecular virology, and particularly relates to nucleic acid molecules encoding a modified equine encephalitis virus viral genome or self-replicating RNA (srRNA) construct, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating cancer.

Abstract: Hierarchical Power Management (HPM) architecture considers the limits of scaling on a power management controller, the autonomy at each die, and provides a unified view of the package to a platform. At a simplest level, HPM architecture has a supervisor and one or more supervisee power management units (PMUs) that communicate via at least two different communication fabrics. Each PMU can behave as a supervisor for a number of supervisee PMUs in a particular domain. HPM addresses these needs for products that comprise a collection of dice with varying levels of power and thermal management capabilities and needs. HPM serves as a unified mechanism than can span collection of dice of varying capability and function, which together form a traditional system-on-chip (SoC). HPM provides a basis for managing power and thermals across a diverse set of dice.

Abstract: Nucleic acid molecules encoding hepatitis B virus (HBV) surface antigens, HBV core antigens, and HBV polymerase antigens, and related combinations, are described. Also described are vectors, such as DNA plasmids or viral vectors, and RNA replicons, expressing the HBV antigens, and pharmaceutical compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the pharmaceutical compositions of the invention are also described.

Abstract: The present disclosure generally relates to the use of different self-amplifying RNA molecules to enhance immune responses, for example immune responses following prophylactic vaccination or therapeutic administration. Some embodiments relate to compositions and methods for inducing an immune response in a subject using prime-boost immunization regimens.

Abstract: The present disclosure generally relates to the use of different self-amplifying RNA molecules to enhance immune responses, for example immune responses following prophylactic vaccination or therapeutic administration. Some embodiments relate to compositions and methods for inducing an immune response in a subject using prime-boost immunization regimens.

Abstract: The present disclosure generally relates to viral-based expression systems suitable for the production of molecule of interests in recombinant host cells. The disclosure particularly relates to nucleic acid constructs, such as expression vectors, containing a modified arterivirus genome or replicon RNA in which at least some of its original viral sequence has been deleted. Also included in the disclosure are viral-based expression vectors including one or more expression cassettes encoding heterologous polypeptides. In some embodiments, the expression cassettes are configured and positioned at defined locations on the viral genome so as to enable expression of the heterologous polypeptides in a tunable manner.

Abstract: The invention provides RNA replicons useful for administering a heterologous protein or peptide into a mammal and eliciting a reduced immune response or no immune response from the mammal. The RNA replicons have RNA sequences encoding for a heterologous protein or peptide, New World alphavirus nonstructural proteins nsP1, nsP2, and nsP4; and an alphavirus nsP3 protein macro domain, central domain, and hypervariable domain. The encoded hypervariable domain can have an amino acid sequence derived from an Old World alphavirus nsP3 hypervariable domain; or can have an amino acid sequence derived from a portion of a New World alphavirus nsP3 hypervariable domain, and another portion derived from an Old World alphavirus nsP3 hypervariable domain.

Abstract: The present disclosure generally relates to viral-based expression systems suitable for the production of molecule of interests in recombinant host cells. The disclosure particularly relates to nucleic acid constructs, such as expression vectors, containing a modified arterivirus genome or replicon RNA in which at least some of its original viral sequence has been deleted. Also included in the disclosure are viral-based expression vectors including one or more expression cassettes encoding heterologous polypeptides. In some embodiments, the expression cassettes are configured and positioned at defined locations on the viral genome so as to enable expression of the heterologous polypeptides in a tunable manner.

Abstract: The present disclosure generally relates to the use of different self-amplifying RNA molecules to enhance immune responses, for example immune responses following prophylactic vaccination or therapeutic administration. Some embodiments relate to compositions and methods for inducing an immune response in a subject using prime-boost immunization regimens.

Abstract: An apparatus comprising a plurality of receivers, a controller and memory storing instructions executable by the controller, the instructions, when executed by the controller causing the controller to receive data of signals received via the receivers as a signal from a transmitter, to segment the received data into a plurality of consecutive segments, to determine if consecutive data segments have changed in a manner indicative of movement of the transmitter and to, based on the determination, determine an angle of arrival of the signal based on data segments that have solely been received before or that have solely been received after a detected change in consecutive data segments indicative of movement of the transmitter or that have been received between two detected changes in consecutive data segments indicative of movement of the transmitter.

Abstract: A system, method and computer program product protects client information used for online transactions by storing transaction details on the client side of a network and avoiding storage on the host side. A hash function may be generated representing a transaction and its details on both the client and server sides. For the transaction to be processed, the hash function from the client side must match the hash function on the host side. Once authenticated, the transaction details may be read and processed while maintaining storage of the client information on the client side of the network.

Abstract: A controller for a distributed antenna system (DAS). The DAS has a plurality of antenna units. Each antenna unit is operable at a first frequency band, defining a first network. The controller comprises a processor; the processor is configured to receive a geo-location traffic specification. The geo-location traffic specification has an indication of a location of a device using the DAS and a traffic requirement of the device. The processor is further being configured to: select an antenna unit or group of antenna units to operate on the first network, based on the received geo-location traffic specification; wherein the antenna unit or group of antenna units is selected to meet the traffic requirement of the device with respect to the first network, in the location of the device.

Abstract: The present disclosure generally relates to nucleic acid molecules for use in regulating gene expression. Disclosed herein include nucleic acid molecules containing one or more structural elements of the viral capsid enhancer operably linked to a coding sequence of a gene of interest. In some embodiments, the viral capsid enhancer comprises a Downstream Loop (DLP) from a viral capsid protein, or a variant of the DLP.

Abstract: An apparatus comprising a plurality of receivers, a controller and memory storing instructions executable by the controller, the instructions, when executed by the controller causing the controller to receive data of signals received via the receivers as a signal from a transmitter, to segment the received data into a plurality of consecutive segments, to determine if consecutive data segments have changed in a manner indicative of movement of the transmitter and to, based on the determination, determine an angle of arrival of the signal based on data segments that have solely been received before or that have solely been received after a detected change in consecutive data segments indicative of movement of the transmitter or that have been received between two detected changes in consecutive data segments indicative of movement of the transmitter.

Abstract: A method for use within a WBAN, the method comprising creating a motion profile and a corresponding channel quality profile and using the motion profile to determining preferable conditions for MAC communication within the WBAN.

Abstract: A method for use within a WBAN, the method comprising creating a motion profile and a corresponding channel quality profile and using the motion profile to determining preferable conditions for MAC communication within the WBAN.

Abstract: A system, method and computer program product protects client information used for online transactions by storing transaction details on the client side of a network and avoiding storage on the host side. A hash function may be generated representing a transaction and its details on both the client and server sides. For the transaction to be processed, the hash function from the client side must match the hash function on the host side. Once authenticated, the transaction details may be read and processed while maintaining storage of the client information on the client side of the network.