Abstract: According to one aspect, embodiments herein provide an electrical connection sensor comprising at least one transducer configured to be coupled to a power distribution block, to generate ultrasonic pulses in the power distribution block, and to receive ultrasonic signals based on the ultrasonic pulses, and a controller coupled to the at least one transducer and configured to determine a status of at least one electrical connection in the power distribution block based on at least one characteristic of the ultrasonic signals received by the at least one transducer.

Abstract: A collision avoidance system for an unmanned aerial vehicle (UAV) receives physical space data for a flight area and creates a virtual world model to represent the flight area by mapping the physical space data with a physics engine. The automatic collision avoidance system creates a virtual UAV model to represent the UAV in the virtual world model. The automatic collision avoidance system receives flight data for the UAV and determines a current position of the virtual UAV model within the virtual world model. The automatic collision avoidance system determines a predicted trajectory of the virtual UAV model within the virtual world model, and determines whether the predicted trajectory will result in a collision of the virtual UAV model with the virtual world model. The automatic collision avoidance system performs evasive actions by the UAV, in response to determining that the predicted trajectory will result in a collision.

Abstract: A system can determine that a simulated (e.g., virtual) weapon has hit a UAV. This can include determining a simulated position of the simulated weapon and the relative position of the UAV. The system can then determine an area of effect for the weapon and determine if the UAV was hit. The system can determine what components of the UAV were hit and to what degree. The system can then determine a simulated condition such as a damaged engine or wing. The system can then receive input for controlling the UAV and combine the input with the simulated condition to generate a control signal for the UAV. The control signal can include decreasing the power to a motor.

Abstract: A power supply includes a DC-DC converter, a boost converter, an energy storage element; and a voltage clamping circuit. The DC-DC converter is connected to a power source with an output voltage in a first voltage range. The voltage clamper circuit is configured to discharge at least a portion of energy of the energy storage element and to produce current at a clamped output voltage range that is substantially equal to the first voltage range. The discharged energy provides hold-up time for the power supply.

Abstract: In various embodiments, a system for controlling radiotherapy equipment in a treatment environment includes a controller for receiving, from one or more image capture devices, data indicating the position of one or more objects in the treatment environment. Based on the position data, the controller defines one or more exclusionary zones from which the radiotherapy equipment is excluded. Each zone has a buffer area surrounding one or more of the objects. The controller further directs the radiotherapy equipment such that a radiotherapy treatment plan is delivered without the equipment entering into the exclusionary zones.

Abstract: A power supply includes a DC-DC converter, a boost converter, an energy storage element; and a voltage clamping circuit. The DC-DC converter is connected to a power source with an output voltage in a first voltage range. The voltage clamper circuit is configured to discharge at least a portion of energy of the energy storage element and to produce current at a clamped output voltage range that is substantially equal to the first voltage range. The discharged energy provides hold-up time for the power supply.

Abstract: The present disclosure relates to a method for determining a respective stem volume for each respective stem of an audio composition including a plurality of stems. A first value for each of one or more parameters is received for a first segment of the audio composition. For each respective stem of the audio composition, a first respective stem volume is determined for the first segment of the audio composition based on the one or more parameters and a volume control layer.

Abstract: According to one aspect, embodiments of the invention provide a current monitoring device comprising a current transformer configured to be removeably coupled to a power line and to generate a reference signal having a level related to a current level of the power line, a sensor circuit connected to the current transformer and configured to convert the reference signal to a measurement signal, a flexible cable having a first end and a second end, the first end coupled to the sensor circuit, and a connection portion coupled to the second end of the flexible cable and configured to be removeably coupled to a communications bus, wherein the sensor circuit is further configured to provide the measurement signal to the communication bus via the flexible cable and the connection portion.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. Certain compounds of this invention are of formula II, V, and/or VII: wherein the variables are as defined herein.

Abstract: According to one aspect, embodiments herein provide an electrical connection sensor comprising at least one transducer configured to be coupled to a power distribution block, to generate ultrasonic pulses in the power distribution block, and to receive ultrasonic signals based on the ultrasonic pulses, and a controller coupled to the at least one transducer and configured to determine a status of at least one electrical connection in the power distribution block based on at least one characteristic of the ultrasonic signals received by the at least one transducer.

Abstract: In various embodiments, a system for controlling radiotherapy equipment in a treatment environment includes a controller for receiving, from one or more image capture devices, data indicating the position of one or more objects in the treatment environment. Based on the position data, the controller defines one or more exclusionary zones from which the radiotherapy equipment is excluded. Each zone has a buffer area surrounding one or more of the objects. The controller further directs the radiotherapy equipment such that a radiotherapy treatment plan is delivered without the equipment entering into the exclusionary zones.

Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications. The compounds of this invention have formula I-A: wherein the variables are as defined herein.

Abstract: In various embodiments, a system for controlling radiotherapy equipment in a treatment environment includes a controller for receiving, from one or more image capture devices, data indicating the position of one or more objects in the treatment environment. Based on the position data, the controller defines one or more exclusionary zones from which the radiotherapy equipment is excluded. Each zone has a buffer area surrounding one or more of the objects. The controller further directs the radiotherapy equipment such that a radiotherapy treatment plan is delivered without the equipment entering into the exclusionary zones.

Abstract: A system for assessing a clinical trial site's subject event reporting rate includes a subject event and visit count processor and a site subject event rate processor. The subject event and visit count processor receives subject event and subject visit data from a plurality of clinical trial sites and calculates for each clinical trial site a total visit count and a total subject event count. The site subject event rate processor receives the total visit count and total subject event count for each clinical trial site, calculates a trial-level subject event rate for the clinical trial, calculates for each clinical trial site an expected total subject event count based on the clinical trial site's total visit count and the trial-level subject event rate, and compares for each clinical trial site the expected total subject event count to the total subject event count to assess the probability that the clinical trial site is under-reporting or over-reporting subject events.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. Certain compounds of this invention have formula IA: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications. The compounds of this invention have formula I-A: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. The compounds of the present invention are represented by the structure of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications. The compounds of this invention have formula I-A: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds of pyrazolopyridine derivatives useful as inhibitors of protein kinase. In one embodiment the compounds of the present invention are represented by the following structural formula: or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods are described for performing a travel search and presenting search results to a user. A computing device may retrieve multiple travel documents and analyze the travel documents to identify points of interest. The computing device may analyze the subset of the travel documents that have points of interest or significant information regarding points of interest. The computing device is configured to calculate a POI relevance score based on text associated with the identified POIs. The POI relevance score indicates how likely the text is relevant to a travel search and rank the subset of the travel documents based on the POI relevance score.