Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase of the following structural formula: The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: Protection circuitry protects a boost converter coupled between input and output nodes for driving a load coupled to the output node. The protection circuitry may comprise a first circuit configured for monitoring a voltage at the output node, the voltage being caused by a signal having a voltage proximate to, or lower than, an input voltage of the boost converter. The protection circuitry may also include a second circuit configured for coupling together the input node with respect to the output node and enabling the boost converter only if the monitored voltage exceeds a reference voltage.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A system and method for providing warnings of a suicide attempt provides monitoring of specific hardware, fixtures, or objects, or structure supporting or associated with same, within an isolation room by way of sensors to provide notice exterior the room that a monitored condition has changed. The sensor can be a load sensor, proximity sensor, contact sensor, or the like. More particularly, an object in an isolation room that provides an attachment potential for hanging is monitored such as by monitoring the load of said object, detecting changes in the load, and providing an alarm of the change in condition. Doors and associated hardware are particularly suitable for such monitoring.

Abstract: Protection circuitry protects a boost converter coupled between input and output nodes for driving a load coupled to the output node. The protection circuitry may comprise a first circuit configured for monitoring a voltage at the output node, the voltage being caused by a signal having a voltage proximate to, or lower than, an input voltage of the boost converter. The protection circuitry may also include a second circuit configured for coupling together the input node with respect to the output node and enabling the boost converter only if the monitored voltage exceeds a reference voltage.

Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: A method of forming a nodular insulation material suitable for installation in a cavity, comprising: propelling fibrous nodules at a substrate, wherein the fibrous nodules are formed from inorganic fibers, wherein the majority of the nodules have a maximum dimension of about one-half inch, and contacting the nodules while the nodules are being propelled, with a solution comprising water and a water soluble binder to produce coated nodules, wherein the coated nodules form an insulation on the substrate.

Abstract: The present invention provides for a device for preparing a glued bio-based panel product test-piece suitable for undertaking an internal bond strength test, the device comprising a base 2, and a press plate 3 and an actuator 4 capable of moving the press plate 3 towards the base 2 with a specific pressure, allowing the bonding of at least one plate to the bio-based panel sample.

Abstract: Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.

Abstract: Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.

Abstract: A screening system designed to provide separation of multiple fractions of New Screens Fines. News Screens Fines (“NSF”) contain a mix of compressed, unmarketable recyclables that are generally less than four inches in size created as a by-product of current Material Recovery Facility (MRF) plant designs used to process single-stream recyclables. The NSF separation system uses a series of primary and secondary classification apparatus to separate materials into marketable products that meet legislative requirements. A series of screens, conveyors and air moving systems are designed to separate waste from fractions of glass, plastic and ferrous metals that can be sold.