Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract: Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.

Abstract: The present invention discloses a method and corresponding apparatus for separating lightweight materials from fabric pieces.

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.

Abstract: A test and measurement system is disclosed. The system includes a data store with a data description of a received in-phase (I) quadrature (Q) symbol. The received IQ symbol is received from a transmitter associated with impairments, and the received IQ symbol is modified from a corresponding ideal IQ symbol by the impairments. A computer processor is coupled to the data store and generates an Error-Vector Magnitude (EVM) function that describes a difference between the received IQ symbol and the ideal IQ symbol in terms of a plurality of impairment parameters indicating the impairments. The processor then determines values for the impairment parameters that quantify the impairments. The values are determined by selection of values for the impairment parameters that minimize the EVM function.

Abstract: Embodiments of the invention include methods and devices for determining a phase angle offset between a phase angle of a local oscillator relative to a phase angle of a signal input of a Device Under Test (DUT). Some embodiments include a laser source and an optical phase adjustor, which may be embodied by a loop stretcher structured to controllably stretch a length of fiber optic cable, driven by a phase adjust driver. In other embodiments the phase angle offset information is conveyed to an oscilloscope for internal compensation.

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

Abstract: The present invention discloses a method and corresponding apparatus utilizing UV-A and UV-C for treatment of textile materials. The method comprises the steps of (a) exposing incoming textile materials to UV-A radiation for detection of optically brightened textile materials and/or synthetic fiber materials; (b) separating detected optically brightened textile materials and/or synthetic fiber materials from the incoming textile materials; (c) exposing the separated incoming textile materials to UV-C radiation for sterilization and surface modification of the textile materials to increase wettability and absorbability and reduce pilling. The apparatus comprises an enclosed segregation chamber disposed with a cascading conveying means, a UV-A radiation source and an optically brightened textile materials and/or synthetic fiber materials separating means therewithin, and an enclosed segregation chamber disposed with a UV-C radiation source therewithin.

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract: A first housing with a polar magnet on a first side. The first housing can include an opening on the first side. A second housing can include a sliding latch. An opposite polar magnet attached to the sliding latch. The polar magnet attracts the opposite polar magnet on the sliding latch to move the sliding latch to a latched position.

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract: Voting systems and methods may include a server comprising a processor and a memory. The processor may receive voting data and analyze the voting data to identify a topic from among a plurality of topics and a vote associated with the identified topic. The processor may tally the vote for the identified topic.

Abstract: A hinge assembly is disclosed herein. An example includes a first knuckle including a first wall that defines a first cavity and second knuckle including a second wall that defines a second cavity. The example also includes a friction element disposed in both the first cavity defined by the first wall of the first knuckle and the second cavity defined by the second wall of the second knuckle to both rotatably and resistively couple the first knuckle to the second knuckle by application of a force directed toward the first wall and the second wall, the friction element including a third wall that defines a third cavity. Modifications and additions to, as well as other examples of, the hinge assembly are also disclosed herein.

Abstract: The present invention discloses a method and corresponding apparatus utilizing UV-A and UV-C for treatment of textile materials. The method comprises the steps of (a) exposing incoming textile materials to UV-A radiation for detection of optically brightened textile materials and/or synthetic fiber materials; (b) separating detected optically brightened textile materials and/or synthetic fiber materials from the incoming textile materials; (c) exposing the separated incoming textile materials to UV-C radiation for sterilization and surface modification of the textile materials to increase wettability and absorbability and reduce pilling. The apparatus comprises an enclosed segregation chamber disposed with a cascading conveying means, a UV-A radiation source and an optically brightened textile materials and/or synthetic fiber materials separating means therewithin, and an enclosed segregation chamber disposed with a UV-C radiation source therewithin.

Abstract: Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.

Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.