Patents by Inventor Steven A. Jacobs

Steven A. Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EGFR AND C-MET FIBRONECTIN TYPE III DOMAIN BINDING MOLECULES
    Publication number: 20140155325
    Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
    Type: Application
    Filed: November 20, 2013
    Publication date: June 5, 2014
    Applicant: Janssen Biotech, Inc.
    Inventors: Anderson Mark, Ricardo Attar, Michael Diem, Linus Hyun, Steven Jacobs, Alastair King, Donna Klein, Sheri Moores, Karyn O'Neil, Kristen Picha
  • EGFR AND C-MET FIBRONECTIN TYPE III DOMAIN BINDING MOLECULES
    Publication number: 20140155326
    Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
    Type: Application
    Filed: November 21, 2013
    Publication date: June 5, 2014
    Applicant: Janssen Biotech, Inc.
    Inventors: Anderson Mark, Ricardo Attar, Michael Diem, Linus Hyun, Steven Jacobs, Alastair King, Donna Klein, Sheri Moores, Karyn O'Neil, Kristen Picha
  • IL4/IL13 binding repeat proteins and uses
    Patent number: 8722618
    Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: May 13, 2014
    Assignee: Janssen Biotech, Inc.
    Inventors: Steven Jacobs, Karyn O'Neil, Michael Baumann, Gaby Sennhauser
  • Stabilized Fibronectin Domain Compositions, Methods and Uses
    Publication number: 20140018519
    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: September 23, 2013
    Publication date: January 16, 2014
    Applicant: Janssen Biotech, Inc.
    Inventor: Steven Jacobs
  • MEDICAL SYSTEM INCLUDING A FLEXIBLE WAVEGUIDE MECHANICALLY COUPLED TO AN ACTUATOR
    Publication number: 20140005646
    Abstract: In general, in one aspect, the disclosure features a system that includes a flexible waveguide having a hollow core extending along a waveguide axis and a region surrounding the core, the region being configured to guide radiation from the CO2 laser along the waveguide axis from an input end to an output end of the waveguide. The system also includes a handpiece attached to the waveguide, wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient and the handpiece includes a tip extending past the output end that provides a minimum standoff distance between the output end and the target location.
    Type: Application
    Filed: August 30, 2013
    Publication date: January 2, 2014
    Applicant: OmniGuide, Inc.
    Inventors: Burak Temelkuran, Charalambos Anastassiou, David Torres, Gil Shapira, Max Shurgalin, Gregor Dellemann, Ori Weisberg, Steven A. Jacobs, Tairan Wang, Uri Kolodny, Jesse Rusk, Robert Payne, Yoel Fink
  • Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
    Patent number: 8617894
    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNF? including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: December 31, 2013
    Assignee: Janssen Biotech, Inc.
    Inventors: Steven Jacobs, Karyn O'Neil
  • Stabilized fibronectin domain compositions, methods and uses
    Patent number: 8569227
    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: October 29, 2013
    Assignee: Janssen Biotech, Inc.
    Inventor: Steven Jacobs
  • Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    Publication number: 20130274145
    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNF? including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: March 18, 2013
    Publication date: October 17, 2013
    Applicant: CENTORCOR ORTHO BIOTECH, INC.
    Inventors: Steven Jacobs, Karyn O'Neil
  • MEDICAL SYSTEM INCLUDING A FLEXIBLE WAVEGUIDE MECHANICALLY COUPLED TO AN ACTUATOR
    Publication number: 20130237976
    Abstract: In general, in one aspect, the disclosure features a system that includes a flexible waveguide having a hollow core extending along a waveguide axis and a region surrounding the core, the region being configured to guide radiation from the CO2 laser along the waveguide axis from an input end to an output end of the waveguide. The system also includes a handpiece attached to the waveguide, wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient and the handpiece includes a tip extending past the output end that provides a minimum standoff distance between the output end and the target location.
    Type: Application
    Filed: January 31, 2013
    Publication date: September 12, 2013
    Applicant: OmniGuide, Inc.
    Inventors: Burak Temelkuran, Charalambos Anastassiou, David Torres, Gil Shapira, Max Shurgalin, Gregor Dellemann, Ori Weisberg, Steven A. Jacobs, Tairan Wang, Uri Kolodny, Jesse Rusk, Robert Payne, Yoel Fink
  • Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    Publication number: 20130096019
    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
    Type: Application
    Filed: August 27, 2012
    Publication date: April 18, 2013
    Inventors: Steven Jacobs, Karyn O'Neil
  • Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
    Patent number: 8415291
    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNF? including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: April 9, 2013
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Steven Jacobs, Karyn O'Neil
  • Fibronectin Type III Repeat Based Protein Scaffolds with Alternative Binding Surfaces
    Publication number: 20130079243
    Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 28, 2013
    Applicant: JANSSEN BIOTECH, INC.
    Inventors: Michael Diem, Steven Jacobs
  • SYSTEM AND METHOD FOR REVERSE DEGRADATION OF A MAGNETOCALORIC MATERIAL
    Publication number: 20130019610
    Abstract: A method includes identifying at least partial degradation of a magnetocaloric material in a magnetic cooling system, wherein the magnetiocaloric material has a Curie temperature. The method also includes regenerating the magnetocaloric material by maintaining the magnetocaloric material at a regenerating temperature, wherein the regenerating temperature is different from the Curie temperature of the magnetocaloric material.
    Type: Application
    Filed: July 18, 2012
    Publication date: January 24, 2013
    Inventors: Carl B. ZIMM, Steven A. JACOBS
  • PHOTONIC CRYSTAL FIBERS HAVING A PREFERRED BENDING PLANE AND SYSTEMS THAT USE SUCH FIBERS
    Publication number: 20120321262
    Abstract: In general, in a first aspect the invention features photonic crystal fibers that include a core extending along a waveguide axis, a confinement region extending along the waveguide axis surrounding the core, and a cladding extending along the waveguide axis surrounding the confinement region, wherein the cladding has an asymmetric cross-section.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 20, 2012
    Inventors: James Goell, Marin Soljacic, Steven A. Jacobs, Tairan Wang, Gokhan Ulu, Burak Temelkuran, Steven G. Johnson
  • Photonic crystal fibers and medical systems including photonic crystal fibers
    Patent number: 8320725
    Abstract: In general, in one aspect, the disclosure features a system that includes a flexible waveguide having a hollow core extending along a waveguide axis and a region surrounding the core, the region being configured to guide radiation from the CO2 laser along the waveguide axis from an input end to an output end of the waveguide. The system also includes a handpiece attached to the waveguide, wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient and the handpiece includes a tip extending past the output end that provides a minimum standoff distance between the output end and the target location.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: November 27, 2012
    Assignee: OmniGuide, Inc.
    Inventors: Burak Temelkuran, Charalambos Anastassiou, David Torres, Gil Shapira, Max Shurgalin, Gregor Dellemann, Ori Weisberg, Steven A. Jacobs, Tairan Wang, Uri Kolodny, Jesse Rusk, Robert Payne, Yoel Fink
  • IL4/IL13 Binding Repeat Proteins and Uses
    Publication number: 20120277143
    Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Inventors: Steven Jacobs, Karyn O'Neil, Michael Baumann, Gaby Sennhauser
  • Fibronectin type III domain based scaffold compositions, methods and uses
    Patent number: 8293482
    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: October 23, 2012
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Steven Jacobs, Karyn O'Neil
  • Fibronectin type III domain based scaffold compositions, methods and uses
    Patent number: 8278419
    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: October 2, 2012
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Steven Jacobs, Karyn O'Neil
  • Photonic crystal fibers having a preferred bending plane and systems that use such fibers
    Patent number: 8280212
    Abstract: In general, in a first aspect, the invention features photonic crystal fibers that include a core extending along a waveguide axis, a confinement region extending along the waveguide axis surrounding the core, and a cladding extending along the waveguide axis surrounding the confinement region, wherein the cladding has an asymmetric cross-section.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: October 2, 2012
    Assignee: OmniGuide, Inc.
    Inventors: James Goell, Marin Soljacic, Steven A. Jacobs, Tairan Wang, Gokhan Ulu, Burak Temelkuran, Steven G. Johnson
  • Stabilized Fibronectin Domain Compositions, Methods and Uses
    Publication number: 20110274623
    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: April 29, 2011
    Publication date: November 10, 2011
    Inventor: Steven Jacobs