Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Abstract: A system for protecting a surface of an electronic device includes a protective film and a liner. The protective film includes an adhesive-coated surface. The liner, which covers the adhesive-coated surface until the protective film is secured to the surface of an electronic device, covers a periphery of the adhesive-coated surface. The liner may also include one or more tabs for facilitating removal of the liner from the adhesive-coated surface of the protective film. Methods for using the system to apply a protective film to a surface, such as a surface of a display screen, of an electronic device are also disclosed.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for managing vehicle guidance using a GUI. One method may include: obtaining flight management system (FMS) data; updating an aircraft configuration state based on the FMS data; obtaining a current mode, active command, and a second command for a guidance panel based on the configuration state; and generating a guidance panel GUI based on the current mode, the active command, and the second command. Another method may include: obtaining vehicle data; updating a vehicle configuration state based on the vehicle data if the vehicle data has updated information; obtaining a current mode, active command, and a second command for a guidance panel of the vehicle based on the vehicle configuration state; generating a guidance panel GUI based on the current mode, the active command, and the second command; and displaying the guidance panel GUI on the guidance panel.

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.

Abstract: Disclosed herein are pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives. The pharmaceutical compositions are for targeted therapeutic applications including, but not limited to, treating cancer-related fatigue, apathy in Alzheimer's Disease, major depression, and attention deficit-hyperactivity disorder. Also disclosed are methods of synthesizing the pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives.

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: An electronic product testing system includes: a testing device configured to generate and to provide a digital image that includes a feature of a product being tested, and to provide product testing instruction for the product; and a tracking device configured for tracking a cursor movement with respect to the digital image, and/or a selection of an item in the digital image, and to generate product testing data based on a result of the tracking; wherein the tracking device is also configured to output the product testing data for storage in a non-transitory medium, the non-transitory medium having a database structure that is configured to store the product testing data in association with the digital image and the product testing instruction.

Abstract: A boot comprises: a shell comprising a first foamed polymeric material; a sock liner comprising a second foamed polymeric material, the sock liner having an exposed section and an enclosed section; and an adhesive layer affixing the shell and the enclosed section of the sock liner; wherein there is an absence of intermingling of the second surface of the enclosed section of the sock liner with the inner surface of the shell. Methods of making and using the boot are also provided.

Abstract: An intrauterine pressure-sensing catheter for detecting pressure changes within the uterus of a patient is disclosed having a tube with a primary lumen extending from a proximal end to a distal end of the elongate tube. A monitor lumen is positioned within the elongate tube between the primary lumen and a wall of the elongate tube and extends from a proximal end of the elongate tube to a distal end of the elongate tube. A pressure-compliant balloon is disposed about an exterior of the elongate tube adjacent a distal end tip. A sleeve is slidably mounted on an exterior of the elongate tube and disposed over the pressure-compliant balloon during insertion of the pressure-sensing catheter within the patient. The distal end tip is configured to prevent movement of the sleeve over the tip and is further configured to provide a zone of protection for the pressure-compliant balloon.

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

Abstract: A system for protecting a surface of an electronic device includes a protective film and a liner. The protective film includes an adhesive-coated surface. The liner, which covers the adhesive-coated surface until the protective film is secured to the surface of an electronic device, covers a periphery of the adhesive-coated surface. The liner may also include one or more tabs for facilitating removal of the liner from the adhesive-coated surface of the protective film. Methods for using the system to apply a protective film to a surface, such as a surface of a display screen, of an electronic device are also disclosed.

Abstract: An epoxy-free laser assembly includes at least one laser array and at least one optics assembly positioned within an optical path of at least one laser array. The laser array and the optics assembly are epoxy-free. In one example, the optics assembly has a beam shaping optic and a wavelength stabilization optic, wherein the wavelength stabilization optic is connected to beam shaping optic with at least one tab and solder. In another example, a plurality of optics assemblies is included within the laser assembly, whereby the laser array and all of the plurality of optics assemblies fit within a footprint of the heatsink. Methods of manufacturing the same are also provided.

Abstract: Downhole formation pressure testing systems are provide. The systems include a drawdown pump, a probe configured to engage with a borehole wall and extract fluid from a formation, and a control element operably connected to the probe and the drawdown pump to perform a formation pressure testing operation. The formation pressure testing operation includes extracting a fluid from the formation for at least three drawdown intervals, monitoring a fluid pressure for a response interval at an end of each drawdown interval, measuring a fluid pressure at an end of each response interval to obtain a data point for each response interval, wherein each response interval is of the same duration, and wherein at least three data points are obtained, and performing a best fit analysis on the at least three data points, wherein the best fit analysis calculates a formation pressure.

Abstract: Systems and methods are presented for quickly obtaining a mortgage payoff report.

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: A method of washing an array of pipette tips (94) with residual biological material includes lowering the array of pipette tips (94) into a wash basin (20) that includes an array of flush ports (22). A vacuum is generated such that the residual biological material in the array of pipette tips (94) is evacuated through the array of flush ports (22). A wash cycle is performed that includes raising the array of pipette tips (94) from the wash basin (20), filling the wash basin (20) with a primary wash fluid, lowering the array of pipette tips (94) into the wash basin (20), miming a pipette tip cleansing cycle, and generating a vacuum such that the primary wash fluid in the array of pipette tips (94) and the wash basin (20) is evacuated through the array of flush ports (22).

Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Abstract: The concepts, systems and methods described herein are directed towards a method for detection and quantification of influence. The system is provided to including: a network sampling processor, a narrative discovery processor, and an influence quantification processor. The network sampling processor is configured to sample information on one or more social media networks. The narrative discovery processor is configured to: receive sampled information from the network sampling processor, and in response thereto identify a narrative related to a subset of information sampled by the network sampling processor. The influence quantification processor is configured to: receive information related to the narrative and to process the information via a network causal inference process to quantify influence of the narrative on the one or more social media networks.