Abstract: Systems and methods for collecting information regarding optical connections in an FDH are disclosed. An example FDH includes: a bulkhead having a plurality of passive optical couplers, each of the plurality of passive optical couplers having a respective first port adapted to receive an end of a respective first optical fiber, a respective second port adapted to receive an end of a respective second optical fiber, and a respective passive optical activity indicator configured to expose (i) a portion of first light propagating in the respective first optical fiber when the first optical fiber is received in the first port, and (ii) a portion of second light propagating in the respective second optical fiber when the second optical fiber is received in the second port; and an image sensor configured to capture one or more images of the respective passive optical activity indicators of the plurality of passive optical couplers.

Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.

Abstract: A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.

Abstract: A waterproof zipper with at least one curve includes a first tape and a second tape, and interlocking elements attached to the first tape and the second tape, wherein the first tape and the second tape are curved, and wherein a curve of at least one of the tapes was caused by compaction of that tape. The zipper is coated on at least one side with a fluid impervious coating.

Abstract: A zipper with at least one curve includes a first tape and a second tape, and interlocking elements attached to the first tape and the second tape, wherein the first tape and the second tape are curved, and wherein a curve of at least one of the tapes was caused by compaction of that tape.

Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.

Abstract: The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.

Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

Abstract: A drainage catheter may include a polymeric tubular member and a braided reinforcement that is disposed about the polymeric tubular member. The braided reinforcement may include a repeating braid pattern that extends over a first portion of a length of the drainage catheter and a modified braid pattern that extends over a second portion of the length of the drainage catheter, the modified braid pattern providing a region without any braid filaments. The drainage catheter may include a drainage hole that extends through the polymeric tubular member within the region without any braid filaments.

Abstract: A boot comprises: a shell comprising a first foamed polymeric material; a sock liner comprising a second foamed polymeric material, the sock liner having an exposed section and an enclosed section; and an adhesive layer affixing the shell and the enclosed section of the sock liner; wherein there is an absence of intermingling of the second surface of the enclosed section of the sock liner with the inner surface of the shell. Methods of making and using the boot are also provided.

Abstract: An impact window assembly for use with an overhead door panel with an opening is disclosed. The impact window assembly includes a glazing sized to cover the opening and has an interior surface that overlap the overhead door panel about that opening. The assembly further includes a front frame having an outer edge at least slightly bigger than the opening in the overhead door panel and an inner edge smaller than the opening. The frame is vacuum-formed onto the glazing and the overhead door panel. The assembly may further include a first plurality of fasteners mechanically engaging the overhead door panel and glazing, a bead of structural sealing applied between the glazing and panel, and mounting tape between the glazing and front frame. Methods for assembling the impact window assembly are also disclosed.

Abstract: The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.

Abstract: An epoxy-free laser assembly includes at least one laser array and at least one optics assembly positioned within an optical path of at least one laser array. The laser array and the optics assembly are epoxy-free. In one example, the optics assembly has a beam shaping optic and a wavelength stabilization optic, wherein the wavelength stabilization optic is connected to beam shaping optic with at least one tab and solder. In another example, a plurality of optics assemblies is included within the laser assembly, whereby the laser array and all of the plurality of optics assemblies fit within a footprint of the heatsink. Methods of manufacturing the same are also provided.

Abstract: A method of securing a filter element within a pressure vessel without a user breaching a plane of the pressure vessel is provided. The method includes attaching a filter locking nut to a removal/installation tool, wherein the removal/installation tool comprises an elongated body, inserting the filter locking nut into the pressure vessel, securing the filter locking nut to a threaded rod to secure a filter element in place, detaching the removal/installation tool from the filter locking nut, and removing the removal/installation tool from the pressure vessel. At least a portion of the elongated body of the removal/installation tool extends outside of the pressure vessel for the duration of the attaching, inserting, securing, detaching, and removing steps.

Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Abstract: A boot comprises: an outsole and an upper affixed to the outsole, the upper comprising a polyvinyl chloride (PVC) upper body and a composite toe cap. The composite toe cap comprises a fiberglass reinforced polymer, and the composite toe cap comprises a tapered surface.

Abstract: An electronic system includes a first data retriever to communicate with a first database associated with an analytic tool, and a second data retriever to communicate with a second database associated with an electronic testing device; wherein the analytic tool is configured to store information regarding actual usage of a product in the first database; wherein the electronic testing device is configured to store product testing data for the product in the second database; wherein the first data retriever comprises a first communication interface to electronically receive the information; wherein the second data retriever comprises a second communication interface to electronically receive the product testing data; and wherein the electronic system further comprises a processing unit configured to compute a score indicating a quality of product testing for the product based on the information regarding the actual usage of the product and/or the product testing data.

Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.