Abstract: A method of diagnosing Alzheimer's disease and related dementias (ADRD) in a patient comprising obtaining a plasma sample from the patient; determining a level of a biochemical sulfide in the plasma sample from the subject by trapping volatilized H2S in the plasma sample using alkaline buffer with monobromobiamine, and detecting the level of biochemical sulfide in the plasma sample, the biochemical sulfide being one of acid-labile sulfide, bound sulfide, and total sulfide; and diagnosing the patient with ADRD when the level of the biochemical sulfide is at least an elevated threshold level for the biochemical sulfide.

Abstract: Purging resources from a cache in a distributed networked system is described. A compute server of a first data center of the distributed networked system receives a purge request to purge a resource from cache. If the purge request does not include a cache key, the compute server determines whether the purge request is valid, and if valid, purges the resource from cache of the first data center, generates a cache key for the resource, and causes the purge request that includes the generated cache key to be sent to other data centers of the distributed networked system for purging the resource from cache. If the purge request includes a cache key, the compute server skips determining whether the purge request is valid and purges the resource from cache based on the cache key.

Abstract: The disclosed method may include receiving laser light from a laser light source. The method may also include directing and distributing the laser light onto a laser-based panel display to render pixels having a reduced spatial coherence and a preserved pixel pitch. For example, the pixels may be rendered as a result of an optical path distance between the pixels being greater than a coherent length of the laser light. Alternatively or additionally, the pixels may be rendered as a result of incoherent addition of light from at least one of multiple ports or multiple sources. Alternatively or additionally, the pixels may be rendered as a result of active modulation of the laser light. Alternatively or additionally, the pixels may be rendered as a result of quasi-random placement of outcoupling elements. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.

Abstract: A diagnostic system for determining the presence of a target in a sample liquid that includes a diagnostic reader and a microfluidic strip having a microfluidic channel network therein. An actuator within the reader modifies the pressure of a gas in gaseous communication with a liquid-gas interface of a sample liquid within the microfluidic channel network to move and/or mix the sample liquid. The pressure modifications may be continuous and/or oscillatory.

Abstract: An apparatus for facilitating control of fluid or slurry movement in a collapsible tube is provided. The apparatus includes the tube. The tube includes first and second opposing wall portions having circumferentially varying thickness including first and second maximum thicknesses respectively, the first and second maximum 5 thicknesses disposed on opposite sides of the tube, and third and fourth opposing wall portions between the first and second opposing wall portions, the third and fourth opposing wall portions having third and fourth circumferentially minimum thicknesses respectively, the third and fourth minimum thicknesses disposed on opposite sides of the tube about halfway between the first and second maximum thicknesses. 10 wherein the first and second opposing wall portions are configured to be engaged by a tube engager to cause the tube to fold at the third and fourth minimum thicknesses to seal the tube. Other apparatuses, systems, and methods are disclosed.

Abstract: A configurable antenna for a software defined radio including a first antenna unit having a first antenna element for receiving a first electromagnetic signal in a first frequency band wherein the first frequency band corresponds to a first mode of operation of a software defined radio, an interface unit having a first connector to couple the first electromagnetic signal from the first antenna unit and a second connector to couple the first electromagnetic signal to the software defined radio, an enclosure configured to receive the interface unit within an internal cavity, and a retention bracket configured to mechanically retain the interface unit within the enclosure, the retention bracket having at least one hole for allowing the first connector to conductively contact the antenna unit.

Abstract: An optical wireless communication (OWC) unit for transmitting and/or receiving data installable in a further device comprises at least one transmitter device for transmitting modulated light comprising an OWC signal of said data and/or at least one receiver device for receiving modulated light comprising an OWC signal representative of said data, wherein the at least one receiver device comprises at least one detector. The OWC unit further comprises analogue electronic circuitry for processing electronic signals and at least one power connection and/or at least one data connection for connection to a power source and/or processing resource of the further device. The OWC unit is operable to provide OWC communication under control of said further device and/or so as to transmit data from/provide data to said further device. The OWC unit is for use in an OWC system having an analogue bandwidth greater than or equal to 80 MHz.

Abstract: A high-voltage protection module for a metrology device includes a metal-oxide varistor (MOV) coupled across a mains power line, a resistor electrically coupled to the MOV in series with the MOV, and a fuse electrically coupled to the MOV and the resistor in series, the resistor being located between the fuse and the MOV. The fuse opens upon an overvoltage event disengaging alternating current (AC) power from the mains power line to the metrology device.

Abstract: An optical scanner includes a base region and a cantilevered silicon beam protruding from the base region. The optical scanner also includes a waveguide disposed on the base region and the cantilevered silicon beam and a transducer assembly comprising one or more piezoelectric actuators coupled to the cantilevered silicon beam and configured to induce motion of the cantilevered silicon beam in a scan pattern.

Abstract: A computer-implemented method may include (1) causing a radar component to emit one or more radar signals and (2) causing the radar component to analyze one or more return signals. Also disclosed is a method for forming a 3D liquid crystal polarization hologram optical element and a method for characterizing diffractive waveguides includes directing light onto a structure and measuring the diffracted light to capture at least one image of the structure. Lastly, disclosed is a method of pattering organic solid crystals and a method directing a beam of input light to a surface of an optical material to determine crystallographic and optical parameters of the optical material. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: An optical scanner includes a cantilevered optical member protruding from the base portion and a transducer assembly comprising one or more piezoelectric actuators coupled to the cantilevered optical member and configured to induce motion of the cantilevered optical member in a scan pattern. In some cases, the cantilevered optical member has a tapered shape with a distal end narrower than a proximal end adjacent to the base portion of the optical scanner. In some cases, the cantilevered optical member has an elongated width along a first plane and includes a plurality of waveguides. The transducer assembly is configured to induce motion of the cantilevered optical member in a second plane orthogonal to the first plane.

Abstract: According to examples, an apparatus for implementing a hermetically-covered photonic integrated circuit on a substrate having an integrated laser diode is described. The apparatus may include a cover wafer, a housing layer including a waveguide, the waveguide including a photonic integrated circuit, a laser die including a laser cavity, and a base substrate. The base substrate may include an emission window to provide a reflective design and to eliminate a need for a polarized beam splitter, a through-wafer via element to electrical coupling to the laser die and one or more pillars to set a height of the laser die relative to the photonic integrated circuit.

Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.

Abstract: A method for odometric monitoring of a rail vehicle includes recording measured values with a sensor in the rail vehicle, and calculating location information and/or speed information from the measured values. The measured values and/or the location information and/or the speed information is stored, and patterns for the measured values and/or the location information and/or the speed information are generated by evaluating the already acquired measured values and/or the location information and/or the speed information. The currently acquired measured values and/or the location information and/or the speed information are synchronized with at least one pattern, and the occurrence of deviations from the patterns is output via an interface. A rail vehicle, a control center, a computer program product and a provision apparatus for the computer program product are also provided.

Abstract: A configurable antenna for a software defined radio including a first antenna unit having a first antenna element for receiving a first electromagnetic signal in a first frequency band wherein the first frequency band corresponds to a first mode of operation of a software defined radio, an interface unit having a first connector to couple the first electromagnetic signal from the first antenna unit and a second connector to couple the first electromagnetic signal to the software defined radio, an enclosure configured to receive the interface unit within an internal cavity, and a retention bracket configured to mechanically retain the interface unit within the enclosure, the retention bracket having at least one hole for allowing the first connector to conductively contact the antenna unit.

Abstract: Purging resources from a cache in a distributed networked system is described. A first data center of the distributed networked system receives a purge request to purge a resource from cache. If the purge request does not include a cache key, the first data center determines whether the purge request is valid, and if valid, purges the resource from cache of the first data center, generates a cache key for the resource, and causes the purge request that includes the generated cache key to be sent to other data centers of the distributed networked system for purging the resource from cache. If the purge request includes a cache key, the first data center skips determining whether the purge request is valid and purges the resource from cache based on the cache key.

Abstract: A medical imaging system comprises a head mount display device through which a user can view a patient or an image of the patient, a first tracking system configured to determine a position and orientation of a medical device, a second tracking system configured to determine a position and orientation of the head mount display device, at least one marker whose position and orientation is detectable by the second tracking system and that has a known or determinable position and orientation relative to a frame of reference of the first tracking system, or whose position and orientation is detectable by the first tracking system and that has a known or determinable position and orientation relative to the head mount display device and processing circuitry configured to register the frame of reference of the first tracking system and a frame of reference of the head mount display device using the position and orientation of the at least one marker and display at least one of: a representation of the medical devic

Abstract: Therapeutics and methods of diagnosing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient comprising obtaining a sample from the patient, determining a level of a signaling lymphocytic activation molecule 1 (SLAMF1) in the sample from the patient, and diagnosing the patient with NAFLD when the level of the SLAMF1 is at least an elevated threshold level for the SLAMF1. Therapeutics and methods of treating non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient in need of treatment comprising administering a pharmaceutically effective dose of a therapeutic, wherein the therapeutic includes a signaling lymphocytic activation molecule 1 (SLAMF1) antagonist.

Abstract: A semiconductor substrate includes a first semiconductor layer, a first dielectric layer coupled to the first semiconductor layer, and a second semiconductor layer coupled to the first dielectric layer. The second semiconductor layer includes a base portion substantially aligned with the first dielectric layer and a cantilever portion protruding from an end of the first dielectric layer. The cantilever portion includes a tapered surface tapering from a bottom surface of the second semiconductor layer toward a top surface of the second semiconductor layer.