Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.

Abstract: A method for fabricating a cantilever having a device surface, a tapered surface, and an end region includes providing a semiconductor substrate having a first side and a second side opposite to the first side and etching a predetermined portion of the second side to form a plurality of recesses in the second side. Each of the plurality of recesses comprises an etch termination surface. The method also includes anisotropically etching the etch termination surface to form the tapered surface of the cantilever and etching a predetermined portion of the device surface to release the end region of the cantilever.

Abstract: Functionality is disclosed for providing status updates for email threads. A personal information management (PIM) server application receive a first message and a second message. The PIM server application can extract a first status value from the first message and a second status value from the second message, and can generate a status notification message that includes one or both of the first status value or the second status value. The PIM server application can also receive a third message subsequent to the first and second messages, and extract a third status value from the third message. Subsequently, the status notification message can be updated by replacing the first status value or the second status value with the third status value in the status notification message. In this manner, the status notification message can provide a consolidated view of the latest status of multiple email threads.

Abstract: A waveguide display system may include an eyepiece waveguide that can have a first surface and a second surface, the waveguide including an incoupling diffractive optical element (DOE) and an outcoupling DOE. The waveguide display system may include a light source and a scanning mirror, and may include reflective and collimating optical elements. The incoupling DOE can be configured to selectively propagate incident light beams to the outcoupling DOE in the waveguide through total internal reflection (TIR).

Abstract: The present invention relates to methods for detecting an analyte present in a fluid sample using a microfluidic device comprising a detection zone characterized by an optically transmissible portion and reagent(s) associated with a porous matrix, wherein the analyte is detected with an optical detector. The present invention also provides a microfluidic channel and a microfluidic cartridge for use in such a method.

Abstract: An optical scanner includes a cantilevered optical member protruding from the base portion and a transducer assembly comprising one or more piezoelectric actuators coupled to the cantilevered optical member and configured to induce motion of the cantilevered optical member in a scan pattern. In some cases, the cantilevered optical member has a tapered shape with a distal end narrower than a proximal end adjacent to the base portion of the optical scanner. In some cases, the cantilevered optical member has an elongated width along a first plane and includes a plurality of waveguides. The transducer assembly is configured to induce motion of the cantilevered optical member in a second plane orthogonal to the first plane.

Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.

Abstract: Embodiments of the present invention are directed to drug delivery systems, dosage forms and methods for the intranasal administration of Bryostatins for the treatment of neuro-degenerative diseases. Inventions of the present application are directed to the treatment of neuro-degenerative diseases such as Hutchinson Disease, Parkinson's disease, Down syndrome and Alzheimer's disease.

Abstract: An inventory of Internet-facing assets related to a target domain is generated using network data gathered from network data sources. Using data sources of known threats, such as malware, phishing attempts, scam pages, blacklisted sites, and so on, a network analytic system generates analytical information about domains, sub-domains, and components that are owned, managed, and/or controlled by a target entity. A measure of domain identity threat is generated based on a classification model using the analytical information.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for presence determination. Systems can include one or more user devices and terminal devices. A current location may be determined of a user that is associated with a particular space of a plurality of different spaces. A plurality of location results may be calculated, wherein each location result is computed using a distinct process of a plurality of processes; and evaluating the plurality of location results to determine a current space of the user; wherein the determining is performed by one or more of, a particular user device, a terminal device, or a server system.

Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.

Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.

Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.

Abstract: A network sensor that features a data store and a packet processing engine. In communication with the data store, the packet processing engine comprises (1) a cache management logic and (2) deduplication logic. The cache management logic is configured to analyze packets to determine whether (a) a packet under analysis include duplicated data and (b) content of the packet is targeted for storage in a same continuous logical storage area as the duplicated data. The deduplication logic, when activated by the cache management logic, is configured to generate a deduplication reference for insertion into the packet prior to storage.

Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for presence determination. Systems can include one or more user devices and terminal devices. A current location may be determined of a user that is associated with a particular space of a plurality of different spaces. A plurality of location results may be calculated, wherein each location result is computed using a distinct process of a plurality of processes; and evaluating the plurality of location results to determine a current space of the user; wherein the determining is performed by one or more of, a particular user device, a terminal device, or a server system.

Abstract: A medical device comprising a structure formed of polyvinyl alcohol.

Abstract: A network sensor that features a data store and a packet processing engine. Communicatively coupled to the data store, the packet processing engine is configured to (i) generate a retention priority for at least a first flow within a first storage region of a plurality of storage regions and (ii) identify, in response to an eviction request, the priority of each of the plurality of storage regions. The priority of the first storage region is partially based on the retention priority associated with the first flow while the priority of a second storage region is based on retention priorities associated with flows stored within the second storage region. The packet processing engine also is configured to identify, through use of the retention priorities of the stored flows within the first storage region, which flows are to be retained and which flows are to be evicted.

Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to trans-port an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.

Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.