Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.

Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid:liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.

Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.

Abstract: Techniques that optimize performance of simultaneous localization and mapping (SLAM) processes for mobile devices, typically a mobile robot. In one embodiment, erroneous particles are introduced to the particle filtering process of localization. Monitoring the weights of the erroneous particles relative to the particles maintained for SLAM provides a verification that the robot is localized and detection that it is no longer localized. In another embodiment, cell-based grid mapping of a mobile robot's environment also monitors cells for changes in their probability of occupancy. Cells with a changing occupancy probability are marked as dynamic and updating of such cells to the map is suspended or modified until their individual occupancy probabilities have stabilized.

Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.

Abstract: Techniques that optimize performance of simultaneous localization and mapping (SLAM) processes for mobile devices, typically a mobile robot. In one embodiment, erroneous particles are introduced to the particle filtering process of localization. Monitoring the weights of the erroneous particles relative to the particles maintained for SLAM provides a verification that the robot is localized and detection that it is no longer localized. In another embodiment, cell-based grid mapping of a mobile robot's environment also monitors cells for changes in their probability of occupancy. Cells with a changing occupancy probability are marked as dynamic and updating of such cells to the map is suspended or modified until their individual occupancy probabilities have stabilized.

Abstract: Techniques that optimize performance of simultaneous localization and mapping (SLAM) processes for mobile devices, typically a mobile robot. In one embodiment, erroneous particles are introduced to the particle filtering process of localization. Monitoring the weights of the erroneous particles relative to the particles maintained for SLAM provides a verification that the robot is localized and detection that it is no longer localized. In another embodiment, cell-based grid mapping of a mobile robot's environment also monitors cells for changes in their probability of occupancy. Cells with a changing occupancy probability are marked as dynamic and updating of such cells to the map is suspended or modified until their individual occupancy probabilities have stabilized.

Abstract: A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.

Abstract: The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays.

Abstract: Fibrous structures that exhibit a Geometric Mean Flexural Rigidity (GM Flexural Rigidity) of less than 40.0 mg*cm2/cm and/or less than 18.0 mg*cm2/cm as measured according to the Flexural Rigidity Test Method described herein and/or a Cross-Machine Direction Flexural Rigidity (CD Flexural Rigidity) of less than 21.0 mg*cm2/cm and/or less than 18.0 mg*cm2/cm and/or less than 17.4 mg*cm2/cm and/or less than 17.25 mg*cm2/cm as measured according to the Flexural Rigidity Test Method described herein are provided.

Abstract: Fibrous structures that exhibit a Geometric Mean Overhang Length (GM Overhang Length) of less than 3.65 cm as measured according to the Flexural Rigidity Test Method and/or a Cross-Machine Direction Overhang Length (CD Overhang Length) of less than 3.875 cm as measured according to the Flexural Rigidity Test Method described herein are provided.

Abstract: Embodiments of the present invention feature methods for treating inflammatory disease and transplantation characterized in that it includes: (i) the incubation of organs with one or more Bryostatin-1 derivatives under conditions which permits vascular exposure to these compounds prior to or immediately following organ ‘harvesting’, and (ii) intravenous, transdermal, intraperitoneal, intra-alveolar instillation of Bryostatin-1 in vivo during active disease, or during periods of disease remission and (iii) prophylactic administration of Bryostatin-1 to limit the development of GVHD.

Abstract: A secure electronic financial funds transfer arrangement including: a funds provider entity who issue a voucher to a customer after registration; a customer seeking to purchase goods and services from a merchant utilising electronic means, or other means intending delivery of valuable goods to the registered address; a verification means available to the merchant with the funds provider entity and whereupon said validation of the voucher issued by the funds provider entity to the customer will result in the transfer of financial funds from the funds provider entity to the merchant and the delivery of the selected goods and/or services to the registered address made by the customer during the registration process before the financial funds transfer voucher was issued by the funds provider entity.

Abstract: Techniques that optimize performance of simultaneous localization and mapping (SLAM) processes for mobile devices, typically a mobile robot. In one embodiment, erroneous particles are introduced to the particle filtering process of localization. Monitoring the weights of the erroneous particles relative to the particles maintained for SLAM provides a verification that the robot is localized and detection that it is no longer localized. In another embodiment, cell-based grid mapping of a mobile robot's environment also monitors cells for changes in their probability of occupancy. Cells with a changing occupancy probability are marked as dynamic and updating of such cells to the map is suspended or modified until their individual occupancy probabilities have stabilized.

Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to trans-port an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.

Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid:liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.

Abstract: Neutrophils (PMN) can migrate along gradients of chemoattractants across endothelial monolayers to sites of inflammation and infection. This chemotaxis through endothelial cell borders is involved in several acute and chronic inflammatory diseases, however our understanding of the role of endothelial second messengers in the regulation of leukocyte emigration is still incomplete. We investigated this using an in vitro model of neutrophil migration across human umbilical vein endothelial cells (HUVECs) and human microvascular endothelial cells (HMECs) on cell culture inserts. We report that activation of endothelial protein kinase C (PKC) by both phorbol myristate acetate (PMA) and Bryostatin-1 (a potent PKC? and c activator) can completely abolish neutrophil migration mediated by both endothelial TNF-? stimulation and a leukotriene B4 (LTB4) gradient. PMA protected against LTB4 induced PMN transmigration for at least 24 hours in HMECs and HUVECs.

Abstract: A system and method for active configuration management of the components of a data repository maintained in memory of a computer system is disclosed herein. The method includes creating a plurality of file system event objects in response to the occurrence of a corresponding plurality of events associated with ones of the components. A plurality of file system event objects are then entered into an event queue. Next, a sequence of configuration management (CM) operations involving identified ones of the components are executed on the basis of corresponding ones of the file system event objects.

Abstract: Method and system for uploading, managing and delivering digital content, including streaming media. The system according to one embodiment allows receives digital content from the client (102), assigns a stream identifier (ID) to the content and stores the content. The client is given a playlist uniform resource locator (URL) for publishing on its web site (610), the URL including the stream ID. Activation of the URL by an end user (104) causes the stream to be served to the end user, without the client receiving or providing an indication of the specifics of where the content was stored. An embodiment of the present provides a system and method that permit clients to actively manage their content, including defining logical folders and subfolders containing item(s) of the content and defining logical stream groups, containing items of the content.

Abstract: The invention relates to a blind of a set of parts for providing a window blind, comprising a plurality of blinds (1) each having a respective different indicia (2) and each having means (3) for supporting the blind at a surround (4) of a window (5). Suitably the support means (3) may be in the form of releasable engagement means such as hooks or hook-like elements at the head of the blind (1), for example held in a head tape. The hooks (3) are releasably engageable with hooks or hook-like elements (6) at a top rail (7) of a surround (4) of the window (5), which hooks 6 may be laterally slidably mounted in a guide for lateral sliding/folding of the blind. However, the blind may also be rollable on itself, or be of a Venetian blind-like construction, or comprised of vertical elements which are rotatable about their longitudinal axes to provide an open or closed blind.