Abstract: The present disclosure relates to a pharmaceutical combination comprising (a) a histone deacetylase 6 inhibitor and (b) an epothilone, including combined preparations and pharmaceutical compositions thereof; uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.

Abstract: A precursor composition comprising, before cure, an acrylic ethylene monomer (AEM), a foaming agent, and one or more of a strengthening additive, a thermal ablation additive, or a reflectivity additive. The precursor composition is cured to form a protective article comprising a foamed protective material. A method of forming a protective article is also disclosed, as is an aerospace structure comprising the foamed protective material.

Abstract: A product delivery system includes a product transport vehicle having at least a plurality of tank compartments, internal valves, control valves, fluid property sensors, temperature sensors, overfill sensors, pressure sensors, a system controller, and a memory module. The product delivery system may be operable to communicatively connect with the loading system at a loading station, a fleet management system, or a cloud system to obtain information, such as the amount of liquid product to be loaded into a tank compartment. The product delivery system may be operable to compare the volumes of the tank compartments with the amounts of liquid product to be loaded at a loading station and maintain the internal valve or control valve in a locked state or transition the internal valve or control valve to an unlocked state based on the comparison. Other comparisons based on liquid type or distribution tank volume can also be made.

Abstract: An emergency evacuation system is configured to be stored in a compartment below an exit door of an aircraft. The emergency evacuation system includes a first floatation device including an internal inflator, and a second floatation device including an open inflation system. The second floatation device is coupled to the first floatation device.

Abstract: The invention relates to a system (400) comprising a vehicle (402), an arm assembly (408), first and second cable portions (410a, 410b), at least one cable actuator (406), and an air supply line. The vehicle has a pneumatic source of pressurized air. The arm assembly has an end effector releasably coupled to an end of an axially-extendable arm coupled to the vehicle. The end effector has a gladhand coupling portion. The air supply line can be coupled to the end effector and can deliver pressurized air from the pneumatic source to a braking system of the trailer when the gladhand coupling portion is coupled to the gladhand receptacle of a trailer. After coupling to the gladhand receptacle, the end effector can be disconnected from the arm assembly to allow the remainder of the arm assembly to be stowed.

Abstract: Embodiments of ladders and adjustable trays are provided herein. In accordance with one embodiment, a ladder includes a first pair of spaced apart rails having one or more rungs extending between and coupled with the first pair of spaced apart rails. A top cap is coupled with the first pair of spaced apart rails. A second pair of spaced apart rails is coupled with the first pair of rails via a pair of hinges. A tray is hingedly coupled with the top cap and selectively positioned between a first deployed position and a stored position, wherein when the tray is in the stored position the tray extends downwards from the top cap towards the pair of hinges.

Abstract: Embodiments relate to polycrystalline diamond compacts (“PDCs”) including a polycrystalline diamond (“PCD”) table having a diamond grain size distribution selected for improving performance and/or leachability. In an embodiment, a PDC includes a PCD table bonded to a substrate. The PCD table includes a plurality of diamond grains exhibiting diamond-to-diamond bonding therebetween. Other embodiments are directed to methods of forming PDCs, and various applications for such PDCs in rotary drill bits, bearing apparatuses, and wire-drawing dies.

Abstract: A method and system are described for communicating within a system, which may be along tubular members and used during gravel pack operations. The method includes constructing a communication network and installing the communication nodes along the gravel pack system. The communication nodes are used to monitor the formation of the gravel pack for voids or gaps during the gravel pack operations. Once the gravel pack is installed, the gravel pack operations may be used for hydrocarbon operations, such as hydrocarbon exploration, hydrocarbon development, and/or hydrocarbon production.

Abstract: A seal for a rotor is provided. The rotor defines an axial direction, a circumferential direction, and a radial direction. The seal includes a first flexible element coupled to the rotor. The first flexible element extends in a first direction that is within forty five degrees of the axial direction.

Abstract: Systems, methods, and compositions provided herein relate to preparation of beads encapsulating biomolecules for performing sequential reactions on the biomolecules. Some embodiments include preparation of nucleic acid reactions within the bead, wherein the bead includes pores that allow diffusion of molecules into or out of the beads while retaining other molecules of interest.

Abstract: Some embodiments include processing data via an executable file on a monitor to reduce the dimensionality of the data being transmitted over the wireless network. The output of the executable file also encrypts the data before being transmitted wireless to a remote server. The remote server receives the transmitted data and makes likelihood inferences based on the recorded data.

Abstract: A system for controlling a catheter-based procedure system that includes a robotic drive configured to control rotational motion and axial motion of one or more elongated medical devices may include a body, a first control coupled to the body, and a second control coupled to the body. First control is configured to instruct the robotic drive to axially move one of the one or more elongated medical devices in response to manipulation of the first control by a user, and the second control is configured to instruct the robotic drive to rotate one of the one or more elongated medical devices in response to manipulation of the second control by the user, wherein the first control and the second control are positioned on the body so the first control and the second control can be simultaneously manipulated by a first digit and a second digit on a hand of the user.

Abstract: A defrost airflow assembly for a heating, ventilation, and air-conditioning (HVAC) case, having a defrost channel starting in a mixing chamber and terminating in a defrost outlet with a defrost door, a demist channel starting in the mixing chamber and terminating in a demist outlet with a demist door, and a bypass channel connected directly with the pre-door defrost channel, the post-door defrost channel, the pre-door demist channel and post-door demist channel. The first bypass channel is configured to allow airflow from the mixing chamber to the defrost outlet when the defrost door is in the closed position and the demist door is in the open position.

Abstract: An integrated electric power take-off includes an electric motor that is driven by an electric motor of an electric vehicle, a hydraulic pump or a similar device that is adapted to operate a rotatably driven accessory provided on the electric vehicle, and a geartrain system connected between the electric motor and the hydraulic pump. The geartrain system is an integral portion of the integrated electric power take-off that permits an optimal selection of the electric motor and the hydraulic pump to be made for each specific application.

Abstract: A carrier head includes a housing, a support assembly having a support plate flexibly connected to the housing so as to be vertically movable, a plurality of fluid-impermeable barriers projecting from a bottom of the support plate to define a plurality of recesses that are open at bottom sides thereof, and pneumatic control lines. A volume between the support plate and the housing includes one or more independently pressurizable first chambers to apply pressure on a top surface of the support plate in one or more first zones. The barriers divide a volume between the support plate and the substrate into a plurality of second chambers. The pneumatic control lines are coupled to the plurality of recesses to provide a plurality of independently pressurizable second zones.

Abstract: The present disclosure provides pharmaceutical compositions comprising a compound having activity as an ACVR1 (ALK2) or ALK5 inhibitor.

Abstract: An actuating assembly including a first actuating device, a second actuating device, and an adjustment mechanism. The first actuating device is configured to provide an output torque to a first portion of a user, and the second actuating device is configured to provide an output torque to a second portion of the user. The adjustment mechanism is connected to the first and second actuating devices. The adjustment mechanism is configured to adjust a distance between the first and second actuating devices.

Abstract: Embodiments of the present invention described herein relate to vacuum cleaners. The vacuum cleaners described herein can include a motor, a lid, a collection receptacle, and at least one support member to permit access to the interior of the vacuum cleaner. Also described herein are vacuum cleaners having a motor, a lid, a collection receptacle, and an accessory holder that can be pivotally mounted to the collection receptacle to permit access to the contents thereof.

Abstract: A snow burial mask of the present disclosure comprises a burial sensor module, a processing unit, and a location tracker. The burial sensor module is configured to measure at least one indication of a snow burial. The location tracker is connected to an external device to receive a first location data and the processing unit. The processing unit is connected to the burial sensor module and configured to determine whether the snow burial has occurred based on measurements of the burial sensor module. The location tracker sends out the location data if the processing unit determines the snow burial has occurred.

Abstract: A surface cleaning head includes a housing having a front side and back side, a brush roll rotatably mounted to the housing within a suction conduit and having at least a portion proximate the opening of the suction conduit, a leading roller mounted to the housing in front of the brush roll, and a drive mechanism operatively coupled to the brush roll and the leading roller for driving the brush roll and the leading roller at same time. The brush roll includes an agitator body and a first bristle/flap arrangement comprising a first deformable flap extending from the agitator body and a first bristle strip and/or row of tufts extending from the agitator body and disposed adjacent to the first deformable flap. The first deformable flap is disposed at an aggressive angle and the first bristle strip and/or row of tufts is arranged at a passive angle.