Abstract: Disclosed are methods of obtaining a cell population enriched for T cells having antigenic specificity for a cancer-specific mutation using in vitro stimulation of memory T cells. Also disclosed are related methods of isolating a T cell receptor (TCR), populations of cells, TCRs or antigen-binding portions thereof, pharmaceutical compositions, and methods of treating or preventing cancer.

Abstract: Methods, apparatus, systems, and articles of manufacture to monitor media are disclosed. An example apparatus includes first means for performing a first mapping of a first media identifier and timestamp to a second media identifier in a look-up table (LUT), the first media identifier and timestamp based on media obtained from a server, the first media identifier to identify the media, means for determining a third media identifier and a second timestamp based on media monitoring information (MMI) obtained from the server, the MMI obtained from the server in response to an access of the media identified by the third media identifier by a media device, second means for performing a second mapping of the third media identifier and the second timestamp to the first media identifier and timestamp in the LUT, and means for crediting access of the media to the media device based on the second mapping.

Abstract: Certain embodiments disclosed herein provide a surgical cassette including a housing, one or more retaining rings coupled to the housing, and one or more valve assemblies coupled to the housing by the one or more retaining rings. The one or more valve assemblies configured to control fluid communication between one or more channels within the housing. Each valve assembly includes a valve body having a first end with a first shoulder, a second end with a second shoulder, a cylindrical surface connecting the first shoulder and second shoulder, and an upper valve elastomer. The upper valve elastomer includes a first side configured to engage with the first shoulder of the valve body and a second side configured to engage with the retaining ring to facilitate a fluidic seal at a base of the housing.

Abstract: An event detecting, monitoring and/or counting mechanism is disclosed. The event may be, for example, a vote, decision or selection which is made by a given entity. A counting solution is provided in which a computing resource, running simultaneously and in parallel to a blockchain, manages a loop-based operation. The computing resource continuously monitors the state of the blockchain as well as any other off-blockchain input data or source. The execution of the loop is influenced by the state of the blockchain. Each iteration of the loop that is executed by the computing resource is recorded in a transaction that is written to the blockchain. It is stored as a hash within the transaction's metadata. If the computing resource finds a transaction which contains a hash relating to the loop it accesses the relevant portion of code.

Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR or EGFR expression and methods of using these splice-switching oligonucleotides to treat cancer.

Abstract: Foldable substrates comprise a substrate thickness from about 80 micrometers to about 2 millimeters. Foldable substrates comprise a first portion, a second portion, and a central portion positioned therebetween. The central portion comprises a central thickness from about 25 micrometers to about 80 micrometers defined between a first central surface area and a second central surface area. A central total thickness variation of the central portion over the first central surface area is less than or equal to 10 micrometers. The central portion comprises a first transition region extending between a first surface area of the first portion and the first central surface area. The first central surface area is recessed from the first major surface by a first distance. A thickness of the first transition region smoothly and monotonically decreases between the substrate thickness of the first portion and the central thickness of the central portion.

Abstract: An electronic door system includes a door frame, a door hingedly coupled to the door frame, an electronic locking mechanism coupled to the door, one or more lights coupled to the door frame, a camera system including at least two of a camera, a proximity or motion sensor, or a doorbell, and a wiring harness extending through the door frame and the door. The wiring harness is coupled to the electronic locking mechanism, the one or more lights, and the camera system. The wiring harness is configured to electrically couple to an external power source.

Abstract: A semiconductor package includes a first layer including a semiconductor die and a shunt embedded within a first dielectric substrate layer, and metal pillars extending therethrough. The semiconductor package further includes a second layer stacked on the first layer, the second layer including a metal trace patterned on the first dielectric substrate layer, and a second dielectric substrate layer over the metal trace. The metal trace electrically connects a first portion of the shunt to a first metal pillar of the metal pillars and electrically connects a second portion of the shunt to a second metal pillar of the metal pillars. The semiconductor package further includes a base layer opposite the second layer relative the first layer, the base layer forming exposed electrical contact pads for the semiconductor package, the electrical contact pads providing electrical connections to the shunt, the metal pillars, and the semiconductor die.

Abstract: According to the present disclosure, air cleaner assemblies, housings, serviceable filter cartridges and features, components, and methods, relating thereto are disclosed. In general, the features relate to systems that are configured to aid in inhibiting an improper cartridge from being installed in an air cleaner housing, during servicing. A variety of features are characterized, and in many examples, the cartridge includes a seal arrangement having radially directed seal surface with at least a first non-wavy or non-projection/recess section and a second wavy or projection/recess section. Examples are shown and described in detail.

Abstract: Provided is a canola variety designated 17GG0168N and seed, plants and plant parts thereof produced from a cross of inbred varieties. Methods for producing a canola variety comprise crossing canola variety 17GG0168N with another canola plant. Methods for producing a canola plant containing in its genetic material one or more traits introgressed into 17GG0168N through backcross conversion and/or transformation, and to the canola seed, plant and plant part produced thereby are described. Canola variety 17GG0168N, the seed, the plant produced from the seed, plant parts and variants, mutants, and minor modifications of canola variety 17GG0168N are disclosed.

Abstract: Methods, apparatus, systems, and articles of manufacture of valve packing apparatus and related methods. An apparatus includes a cartridge including packing components and a spring. The cartridge is dimensioned to fit in a bore of a bonnet of a valve. A retainer is disposed in an aperture of the cartridge. The retainer is removable from the aperture to release the spring to apply a predetermined compressive load to the stack of packing components.

Abstract: A lighting system includes a power supply configured to receive an AC input signal and to generate a rectified signal; a light driver configured to generate a drive signal to drive a light source based on the rectified signal; and a housing configured to encapsulate the power supply and the light driver, the housing including a heatsink base forming a bottom portion of the housing and a case cover forming a top portion of the housing, the heatsink base being configured to channel heat away from the lighting system, the heatsink base including a base plate; a base post configured to couple the base plate and the case cover; and a base sidewall extending from the base plate and configured to mate with cover sidewalls of the case cover.

Abstract: An electronic device can include a housing defining an aperture and at least partially defining an internal volume of the electronic device, an electromagnetic radiation emitter and an electromagnetic radiation detector disposed in the internal volume, and an optical component disposed in the aperture. The optical component can include a first and second transparent portions disposed above the electromagnetic radiation detector and the electromagnetic radiation emitter, and an opaque portion disposed between the first and second transparent portions and extending a thickness of the optical component. The first transparent portion, the second transparent portion, and the opaque portion can define a flush exterior surface of the electronic device.

Abstract: A cooling device for products disposed in an arrangement including an elongate plenum having a length that approximates the transverse dimension of the arrangement and a passageway extending from its first end to its second end. A structure coupled to the elongate plenum is adapted for positioning the elongate plenum across arrangement. A blower is coupled to the first end of the elongate plenum for providing a pressurized fluid to the passageway. The elongate plenum has a substantially continuous nozzle extending along its length for directing pressurized fluid from the passageway for travel over a side wall of the plenum towards the arrangement. The side wall has a configuration so that the pressurized fluid traveling over the side wall entrains fluid external of the elongate plenum for amplified cooling of products in the arrangement.

Abstract: Systems and methods for updating metadata. In some embodiments, processing hardware may receive an input metadata pattern associated with an instruction executed by a host processor. The input metadata pattern may comprise: one or more first input metadata labels associated with the instruction and/or a state of the host processor; and one or more second input metadata labels associated, respectively, with one or more registers used by the instruction and/or one or more memory locations referenced by the instruction. The processing hardware may generate an output metadata pattern, wherein: the one or more first input metadata labels are used to determine how to process the one or more second input metadata labels to generate the output metadata pattern.

Abstract: Formulations and methods for ameliorating symptoms associated with metabolic disorders, such as hypoglycemia, obesity, diabetes, and the like by targeted administration to the oesphagus of a subject of Zn-?2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as ? adrenergin receptor agonists, ? adrenergin receptor antagonists, and/or glycemic control agents.

Abstract: Preventing applications from overconsuming shared storage resources, including: identifying one or more sub-regions of data stored on a storage device that are associated with an application of a known application type; compiling information describing the application's utilization of a storage system; determining that a storage system objective has not been met; and initiating, based on the information describing the application's utilization of the storage system, remediation actions.

Abstract: A shaker for housing and dispensing food or drink items. The shaker has a top can sitting atop a bottom can. Each can contains a separate component. The top can is removed and its contents are added to the second can. This allows the user to control how much of the contents from the top can are added to the bottom can. A single multi-compartment vessel houses two separate ingredients and prevents their mixing.

Abstract: Provided herein are Complement Factor I (CFI) variants that exhibit at least one improved characteristic relative to a wild type CFI. CFI variants of the disclosure can exhibit tunable specificity and activity. Also included are CFI-containing fusion constructs comprising at least one domain of CFI, for example, wild type full length CFI fused to human serum albumin. Also included are methods of making and using such CFI variants and fusion constructs. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.

Abstract: A probe apparatus includes a plurality of nested sheaths including an inner sheath forming an inner sheath passage and an outer sheath forming an outer sheath passage. A cannula forms an actuator linkage that extends from a proximal linkage end portion to a distal linkage end portion. The actuator linkage extends through the inner sheath passage from the proximal end portion at a main body forming a handle portion to the distal linkage end portion and forms a lumen therethrough. A blade is in connection with the distal linkage end portion and the inner sheath. An imaging apparatus includes an imager extending through the cannula at the distal linkage end portion and captures image data in a field of view.