Abstract: The present disclosure relates to an epoxy tube for an optical fiber connector. The tube can be mounted to a ferrule hub by a snap fit connection. The connection between the tube and the ferrule hub allows for float of the epoxy tube where the epoxy tube is not rigidly attached to the hub. The epoxy tube can be configured to move about an arc of rotational circular movement while remaining linear such that the epoxy tube does not bend or transfer forces to the hub.

Abstract: A power system for a work machine includes a connection arrangement. The connection arrangement facilitates an operative engagement of terminal sets to provide passage to an electrical connection therethrough and route electrical power supply from electrical power sources to electrical devices of the work machine through the connection arrangement. Further, the connection arrangement facilitates an operative engagement of connector sets to provide passage to communication links therethrough and route data transmission through the connection arrangement. A system for determining a state of the electrical connection between the terminal sets includes a controller configured to detect the data transmission through the communication links; determine the state of the electrical connection between the terminal sets as connected when the data transmission is active; and determine the state of the electrical connection between the terminal sets as disconnected when the data transmission is inactive.

Abstract: The present invention provides methods of treating and improving the symptoms of multiple sclerosis using an antibody or antigen-binding fragment thereof that specifically binds human CD19 (e.g., obexclimab).

Abstract: A system and method for treating heart failure of a patient by occluding blood flow from the azygos vein to the superior vena cava while allowing blood to flow through a shunt from the right pulmonary artery to the azygos vein. The system can include an occluder with an expandable cage positioned in the azygos vein to selectively control the flow of blood to the superior vena cava. The occluder can expand and collapse based on pressure measurements received from implanted pressure sensors.

Abstract: A suction device comprising a suction tube configured to fluidly couple to a vacuum source and to provide suction at its distal end, an illumination assembly comprising at least one direct light source for emitting light to a target area, an elongated heat sink thermally coupled to the at least one light source and extending along a portion of the suction tube, and a spine extending along the suction tube and overlapping with the elongated heat sink, the spine including an integrated lens, wherein the at least one direct light source and the elongated heat sink are enclosed within a space formed between the spine and a side of the suction tube.

Abstract: Additive manufacturing systems and associated methods are disclosed herein. In some embodiments, the additive manufacturing system includes a build chamber that has active build region, a support platform positioned in the active build region, a recoater arm, and a chamber-purging system. The recoater arm is movable in a lateral direction along a travel path above the active build region to spread a powder over the active build region. The chamber-purging system includes extendable input and return channels that are movable between a first position outside the travel path and a second position at least partially within the travel path.

Abstract: The invention relates to the use of a powdered mixture of zinc flake and of zinc oxide Zn/ZnO to increase the value of the coefficient of adhesion of an anti-corrosion coating, characterised in that the zinc flake represents between 60 and 99% of the mixture of zinc flake and zinc oxide, and more particularly between 70 and 95% of the mixture of zinc flake and zinc oxide. The invention also relates to methods for obtaining and applying the anti-corrosion coating, and to the anti-corrosion coating per se and to substrates covered with the coating.

Abstract: A work machine using a distributed controller network that provides for redundant data buses is described herein. The work machine uses a controller area network that provides for redundant data buses for tier 1 controllers, or controllers that are determined to have a higher degree of importance when compared to other controllers. The controller area network uses redundancy to decrease the probability of a communication failure between tier 1 controllers and tier 2 controllers. The tier 1 controllers have communication access to two data buses between other tier 1 controllers and tier 2 controllers. Thus, if a data bus used by a tier 1 controller cannot be used by the controller, the tier 1 controller can use the other, redundant data bus to maintain communication.

Abstract: A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.

Abstract: A satellite communication system includes a first frequency reference generator of a terminal, a broadband communication receiving channel, a second frequency reference generator of the terminal, and a broadband communication transmission channel. The first frequency reference generator generates a first frequency reference signal in a first frequency band. The broadband communication receiving channel for receiving broadband data at the terminal using the first frequency reference signal, wherein a legacy satellite system comprises a legacy communication transmission channel for transmitting data from a legacy satellite in the first frequency band. The second frequency reference generator generates a second frequency reference signal in a second frequency band.

Abstract: Some embodiments provide systems for use in controlling irrigation, comprising: an irrigation controller configured to couple with one or more valves at a site and to control activation and deactivation of the one or more valves in accordance with an irrigation schedule stored in the irrigation controller; a wireless adapter directly communicationally coupled through a direct wired connection with the irrigation controller; and a network adapter wirelessly coupled over a point-to-point wireless communication path with the wireless adapter, wherein the network adapter is configured to further couple through a direct wired connection with a local router configured to provide communication over a distributed network to a remote server; wherein the wireless adapter is configured to poll the irrigation controller to acquire and locally store status information; and the wireless adapter is configured to communicate, over the point-to-point wireless channel, the status information to the server.

Abstract: A flow-through folding membrane accumulator comprises a hollow cylindrical housing and a folding flexible membrane disposed in an interior volume of the housing. The membrane defines an interior liquid channel extending through the membrane along a longitudinal axis, and liquid coolant flows from an inlet of the accumulator through the interior liquid channel to an outlet of the accumulator. The membrane is sealed to the housing such that an air-tight cavity filled with a gas is formed between the housing and the membrane. The cavity radially surrounds the internal liquid channel, with the membrane separating the cavity and the internal liquid channel. Volumes of the cavity and channel change in response to deformation of the membrane and based on pressures of the liquid coolant. The membrane may comprise multiple folds extending parallel to the longitudinal axis and distributed circumferentially around the axis.

Abstract: Landscaping systems providing edging while also providing for improved water distribution, weed control and plant growth. One embodiment of a landscape edging and barrier irrigation system according to the present invention comprises a barrier strip having an integral edge tube capable of carrying a flow of water. A weed barrier is included comprising a barrier sheet with a barrier tube grid capable of carrying a flow of water. At least a portion of water flowing through the edge tube flows through the barrier tube grid, and the barrier tube grid comprises one or more grid openings to allow water to flow from the barrier tube grid.

Abstract: Ionizable cationic lipids, methods for synthesizing the same, intermediates useful in synthesis of the ionizable cationic lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is an LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.

Abstract: The invention provides particulate material suitable for use in manufacturing a three-dimensional object, the material comprising a plurality of particles. Each particle has a thermoplastic polymeric core; and a polymeric shell that coats the polymeric core. The polymeric core makes up 75 wt % or more of each particle. The polymeric shell is formed from a co-polymer of a major monomer and a minor monomer, wherein the major monomer comprises a polymerisable group, and the minor monomer comprises (i) a polymerisable group; and (ii) a functional component, and wherein the co-polymer is formed by reaction of the polymerisable group on the major monomer with the polymerisable group on the minor monomer.

Abstract: The compound 1,1-dioxido-2,3-dihydrothiophen-3-yl 4-phenoxybenzenesulfonate, pharmaceutical compositions thereof, and use of the compound and the pharmaceutical compositions for treating cancer and pulmonary diseases are disclosed.

Abstract: Novel tools and techniques are provided for implementing error detection in a network, and, more particularly, to methods, systems, and apparatuses for implementing error and/or fault detection in a network and/or media stream and providing options to address the error and/or fault in the network and/or media stream. In various embodiments, a computer might detect an error in a first network and send a notification indicating that the error has occurred. The notification might contain one or more options to address the error in the first network. The computer, a user device, a service provider device, or a content provider device might receive and display the notification containing the one or more options. The computer, the user device, the service provider device, or the content provider device might then select at least one of the one or more options to address the error in the first network.

Abstract: System, methods, and other embodiments described herein relate to implementing trailer sway detection strategies. In one embodiment, a method includes receiving a lateral motion signal; determining if a number of peaks in the lateral motion signal satisfies a first criterion; determining if a cross-correlation of yaw acceleration and lateral acceleration satisfies a second criterion; disabling lane keeping assistance if the first criterion is satisfied; and determining if a trailer sway event is in progress if the first criterion and second criterion are satisfied.

Abstract: This invention relates to polynucleotides comprising optimized CLN5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLN5 gene or aberrant activity of a CLN5 gene product in the subject, such as CLN5 disease.

Abstract: A work machine using a direct current power system that isolates reactive loads is described herein. The work machine uses a machine power distribution unit that receives direct current power from two or more battery banks of a power unit, whereby each of the battery banks deliver electrical power on a separate direct current bus. A machine power distribution unit of the work machine receives the electrical power from the battery and is used to isolate the power using bus connectors. One of the battery banks provides power to one direct current bus of the work machine and another battery bank provides power to another direct current bus of the work machine. A reactive load serviced by one of the battery banks is electrically disconnected from another reactive load serviced by the other battery bank.