Abstract: Disclosed are compounds of Formula (I): or a pharmaceutically acceptable salt, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein R2, R3, R4, Y1, Y2, X, and Z are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

Abstract: A method and system for determining a location of a seismic event is described which comprises detecting three or more seismic signals in seismic activity associated with the seismic event that is monitored by three or more seismic signal detectors and for each of the detected signals detected by a respective signal detector then classifying, by the respective signal detector a corresponding detected signal with a respective frequency content classification based on determining whether a frequency content of the corresponding detected signal exceeds a frequency content threshold. The method and system further includes determining for each of the classified signals a respective seismic signal onset timing corresponding to an arrival time of the classified signal at the respective detector and determining the location of the seismic event based on the respective seismic signal onset timings and the respective frequency content classifications of each of the classified signals.

Abstract: A walk-behind blower includes a frame; one or more movable elements mounted to the frame to movably support the frame; a housing supported on the frame, the housing defining an airflow conduit extending therethrough between a first end and a second end; and a fan assembly disposed between the first end and the second end, the fan assembly comprising a blower fan having a plurality of fan blades, and a motor rotatably connected to the blower fan.

Abstract: Technology is described for referencing anatomical structure using an AR headset. The method can include registering a marker located on a distal anatomical structure. The marker may have a pose that includes a position and orientation in a 3D coordinate system of the AR headset. Another operation may be identifying a proximal anatomical structure to which the distal anatomical structure is connected. The marker may be registered at a second pose having a second position and second orientation. A joint pivot axis and angle may be determined with respect to the proximal anatomical structure by comparing the first pose and the second pose. The joint pivot axis may then be displayed, using the AR headset. The technology may also use a pointer device to automatically find an anatomic path and anatomic length.

Abstract: A cordless compressor has an air storage tank, a pump, a motor for driving the pump, and a controller circuit electrically connected to the motor. A pressure switch assembly is connected to the controller circuit. The pressure switch assembly has first and second pressure switches for sensing pressure within the air storage tank. The controller circuit controls de-activation of the motor depending upon status of the first and second pressure switches.

Abstract: The present disclosure provides for a hydrogel formulation comprising a therapeutically effective amount of an extract of the Croton lechleri tree. The present disclosure also provides for a method of treating a dermatological condition in a subject via the topical administration of a hydrogel formulation comprising a therapeutically effective amount of an extract of the Croton lechleri tree.

Abstract: The present disclosure relates to CRISPR-Cas systems that utilize Cas12L for binding to and modifying nucleic acids in eukaryotic cells in a temperature regulated manner. Methods and compositions for using these CRISPR-Cas systems for editing nucleic acids for use in disease treatment and prevention in eukaryotic cells are provided herein.

Abstract: A chemical reservoir assembly may include a reservoir containing a liquid chemical and a closure sealing off an outlet opening of the reservoir. The closure can include a top wall having an access opening and a sealing disc positioned under the top wall and across the access opening. The sealing disc may include a vent opening positioned under the top wall and offset from the access opening. The sealing disc can be fixedly positioned relative to the top wall and include a compressible material configured to compress in response to a discharge device being inserted into the access opening and pressing against the compressible material. In response to the force of the discharge device, the compressible material can compress to open a venting pathway from the access opening through the at least one vent opening.

Abstract: In part, in one aspect, the disclosure relates to a first computer system including a first processor and first memory, a first IO storage subsystem including a first switch configured for one or more first storage devices, a first IO non-storage subsystem including a first which configured for one or more first non-storage devices, a second compute system including a second processor and second memory, a second storage IO subsystem including a second switch configured for one or more second storage devices, a second IO non-storage subsystem including a second switch configured for one or more second non-storage devices and a midplane including a power connector, a processor side and an IO side, wherein the processing side includes connectors in electrical communication with the computer systems, the IO side includes connectors in electrical communication with the storage and non-storage subsystems.

Abstract: In a method of using structured communications in an observation platform with cloud computing, a signal from a first communication device is received by a second communication device associated with a first computer system. The second computer system forwards the signal from the first computer system to a second computer system, wherein the second computer system is physically remote from the first computer system and connected with the first computer system via a network. The second computer system derives context information for the signal, the deriving based on a plurality of factors derived from an analysis of the signal, wherein the plurality of factors comprises a speech to text analysis of the signal, and wherein the second computer system is cloud based. The second computer system determines at least one destination for the signal based on the plurality of factors for the context information.

Abstract: An isolation bar for a chin-up or pull-up bar extends parallel or at an acute angle (angled facing upwards) and is below a grasping region of the chin-up or pull-up device. The isolation bar can be hung from the chin-up or pull-up bar by way of cables/elongated straps or be fixed to a door frame, wall mounted, or free standing device with the grasping region. In use, the forearms of a user are pushed against the isolation bar while carrying out a chin-up or pull-up.

Abstract: The present disclosure provides a clamp mechanism to secure a temperature sensor to a plumbing fixture. The clamp includes a first semicircular portion and a first sensor housing lobe; a second semicircular portion and a second sensor housing lobe; wherein the first and second sensor housing lobes being hingedly coupled together and defining a first bore between the first and second semicircular portions to fit around pipe structures and around a test cock, and wherein the first and second sensor housing lobes defining a second bore between the first and second sensor housing lobes to house a temperature sensor configured to generate temperature sensor data indicative of an ambient temperature around the plumbing fixture.

Abstract: Some disclosed systems and methods include assigning channel streams to satellite playback devices, delaying initial transmission of surround sound content to satellite playback devices to accumulate audio samples for transmission in individual frames of surround sound content, and taking advantage of configured playback delays for different channels of surround sound content to prioritize transmission of channels of surround sound content having shorter configured playback delays over transmission of channels of surround sound content having longer configured playback delays.

Abstract: Additive manufacturing systems and associated methods are disclosed herein. In some embodiments, the additive manufacturing system includes a build chamber that has an active build region, a support platform positioned in the active build region and movable in an upward direction, and a recoater arm positioned in the build chamber and movable in a first lateral direction above the active build region. The recoater arm can spread a powder over the active build region during a build process using first and second blades. The recoater arm can also include at least one orifice component positioned between the first and second blades to block a flow of the powder while the at least one orifice component is stationary and a vibrational component operably coupled to the at least one orifice component. The additive manufacturing system can also include a controller operably coupled to the vibrational component, to control operation of the vibrational component.

Abstract: A method for generating computational predictions associated with a real-world entity is disclosed. The method comprises analyzing knowledge from a plurality of data sources; determining investment objectives associated with the real-world entity; applying, a plurality of ensembles of machine learning models to each of the plurality of data sources to conduct a combinatorial analysis of the plurality of data sources; generating, by colonies of Artificial Intelligence (AI) colonizers, intermediary outputs; analyzing the intermediary outputs in a weighted combination to generate weighted outputs; and assembling, by a supervisory algorithm, the weighted outputs based on the investment objectives to generate a computational prediction associated with the real-world entity.

Abstract: A connector module includes: 1) a first terminal module comprising a row of first terminals; 2) a second terminal module comprising a row of second terminals; and 3) a first holder, wherein the first terminal module and the second terminal module are respectively installed on the top and bottom of the first holder. The connector module further includes: 4) a third terminal module comprising a row of third terminals; 5) a fourth terminal module comprising a row of fourth terminals; and 6) a second holder, wherein the third and fourth terminal modules are respectively installed on the top and bottom of the second holder.

Abstract: Vaporizer cartridges and vaporizer apparatuses, and methods for making, using and delivering vapor to a user, that are leak-resistant for use with cannabinoids. In particular, described herein are leak-resistant vaporizer cartridges and apparatuses adapted for use with oil-based vaporizable materials including cannabis oils.

Abstract: A computer-implemented method is disclosed that includes: receiving, at a mempool node of distributed mempool network (DMP) implementing a distributed hash table (DHT), a request to update routing information of the mempool node; initializing a set of random walks within a key space of the DHT; generating a first record in an first table based at least in part on a first identification information stored in a second of a long-distance table type; generating a second record in a third table of the long-distance table type by at least performing a first random walk of the set of random walks, the second record containing a second identification information and an address associated with the second identification information; generating a third record in a fourth table of a short-distance table type by at least obtaining records from a table maintained by a second mempool node of the DMP network.

Abstract: The disclosure relates to a method for processing a complementary field effect transistor, CFET, device. The method comprises the steps of forming at least one fin structure on a substrate, wherein the at least one fin structure comprises a horizontal top surface and two vertically oriented side surfaces between the top surface and the substrate, and wherein the at least one fin structure comprises a first layer stack and a second layer stack above the first layer stack, and forming a gate dielectric layer with a non-uniform layer thickness around the at least one fin structure, wherein the layer thickness of the gate dielectric layer which is arranged on the top surface of the at least one fin structure is larger than the layer thickness of the gate dielectric layer which is arranged on the side surfaces of the at least one fin structure.

Abstract: In part, in one aspect, the disclosure relates to a method of enabling hot plugging operations in a computer system. The method mat include initializing a platform driver, wherein the platform driver is installed on a computer system running an operating system; disabling, using the platform driver, an interrupt function and a hardware detection notification function of the computer system; hot plugging a PCIe node in the computer system; detecting, using the platform driver, the hot plugging of the PCI node in the computer system; configuring the PCIe node, using the platform driver, wherein the configured PCIe node comprises a PCI hierarchy, the PCI hierarchy comprising an allocation of PCI bridges and devices of the configured PCIe node; and bringing the devices of the hot plugged configured PCIe node into service for use by the computing system.