Abstract: Disclosed herein is a medical device for extended release of drugs. The device comprises a stent embedded with one or more drug depots that release of a therapeutic agent in a controlled manner. Each end of the stent may contain one or more anchors or attachment points which enable self-retention of the medical device once properly placed. The disclosed device further comprises a biosensor to monitor physiological characteristics like, e.g., intraocular pressure (IOP).

Abstract: A method of storing data on a blockchain, such as the bitcoin blockchain, is disclosed. The method comprises generating a blockchain transaction having at least one first input and/or at least one first output containing first data (<Content 1>) to be stored on the blockchain, and at least one second input and/or at least one second output containing second data (<Attribute 1>,<Attribute 2>) representing at least one attribute of the first data. At least one second input and/or at least one second output is separate from the or each first input and/or first output.

Abstract: Three dimensional nonwoven materials and absorbent articles comprising such materials are disclosed. In one embodiment, an absorbent article may comprise an outer cover, a bodyside liner, an absorbent body, and a nonwoven material coupled to the bodyside liner. The nonwoven material may comprise an apertured zone providing a percent open area for the apertured zone that is greater than about 15%. The nonwoven material may be coupled to liner by a front waist bond forming a front waist bonding region which extends through the apertured zone and a rear waist bond forming a rear waist bonding region, wherein the rear waist bonding region has a length that is between about 2% and about 10% of the material length and the front waist bonding region has a length that is between about 20% and about 50% of the material length.

Abstract: Provided is a canola variety designated 40056173-41 and seed, plants and plant parts thereof produced from a cross of inbred varieties. Methods for producing a canola variety comprise crossing canola variety 40056173-41 with another canola plant. Methods for producing a canola plant containing in its genetic material one or more traits introgressed into 40056173-41 through backcross conversion and/or transformation, and to the canola seed, plant and plant part produced thereby are described. Canola variety 40056173-41, the seed, the plant produced from the seed, plant parts and variants, mutants, and minor modifications of canola variety 40056173-41 are disclosed.

Abstract: An exercise machine has a lock mode and an unlock mode associated with a screen lock function. A computing device coupled to the exercise machine includes a display, memory, and a processor coupled to the memory. The computing device is configured to detect a user interaction with the computing device or the exercise machine while the exercise machine is in the lock mode, render a screen lock interface on the display in response to the user interaction, receive an input code from the screen lock interface, determine that the input code matches a goal code, and adjust the exercise machine from the lock mode to the unlock mode in response to determining that the input code matches the goal code.

Abstract: A system, method, and computer-program product includes selecting, by a controller node, a plurality of hyperparameter search points from a hyperparameter search space; instructing, by the controller node, one or more worker nodes to concurrently train a plurality of machine learning models for a target number of epochs using the plurality of hyperparameter search points; receiving, from the one or more worker nodes, a plurality of performance metrics that measure a performance of the plurality of machine learning models during the target number of epochs; and removing, by the controller node, one or more underperforming hyperparameter search points from the plurality of hyperparameter search points according to a pre-defined performance metric ranking criterion associated with the plurality of performance metrics.

Abstract: In an embodiment, a system, includes: a first pressurized load port interfaced with a workstation body; a second pressurized load port interfaced with the workstation body; the workstation body maintained at a set pressure level, wherein the workstation body comprises an internal material handling system configured to move a semiconductor workpiece within the workstation body between the first and second pressurized load ports at the set pressure level; a first modular tool interfaced with the first pressurized load port, wherein the first modular tool is configured to process the semiconductor workpiece; and a second modular tool interfaced with the second pressurized load port, wherein the second modular tool is configured to inspect the semiconductor workpiece processed by the first modular tool.

Abstract: A hot melt adhesive composition comprises a polymer comprising poly(?-methyl-?-propiolactone) (PMPL) or a derivative thereof, wherein the PMPL is polymerized from a plurality of (R)-?-methyl-?-propiolactone monomers and a plurality of (S)-?-methyl-?-propiolactone monomers, wherein the ratio of (R):(S) monomers is from about 90:10 to about 10:90. Changing the (R):(S) ratio impacts the isotactic diad fraction and consequently the crystallinity and thermomechanical properties of the resulting PMPL. The PMPL may be hydroxyl-terminated, with the residue thereof serving as the elastomeric B block in an A:B:A triblock copolymer having hard end A blocks, such as a residue of polylactic acid. The PMPL diol may also be used as a reactant to form an alkoxysilane-terminated polymer, a polyurethane, or a (co)polyester. In some embodiments, such triblock polymers may be entirely bio-sourced and compostable.

Abstract: An ultrasonic surgical handpiece includes a motor having a transducer assembly along a central axis of the surgical handpiece. The motor is configured for operative connection to a power source. A surgical attachment has a proximal end detachably connected to the motor and a distal end defining a working plane for engagement with biological tissue. A housing has a housing distal end, a housing proximal end, and a cavity configured to receive the motor and the surgical attachment. An irrigation path of the housing is configured to communicate irrigation fluid. The irrigation path has an inlet proximate the housing proximal end operatively connected to an irrigation fluid source, and an outlet proximate to the working plane. The irrigation path is separated from the housing cavity to prevent contact between the irrigation fluid and an operational portion of the surgical attachment.

Abstract: A system that analyzes a user's communications to select a promotion that is presented to the user. The analysis may occur in two stages: a first stage analyzes a single communication from a user to determine whether the user is a potential target for a promotion; for potential targets, a second stage analyzes a history of communications from the user to generate a user profile. The system may then select a promotion based on the profile. The profile may include a set of profile tags that are considerably more detailed and granular than traditional demographic data; tags may for example indicate user affiliations with groups or ideas (such as religions or political parties), or user life cycle stages. Using these rich, detailed user profile tags, the system may achieve promotion response rates far above those from traditional advertising, which relies on cookies or simple demographic categories.

Abstract: An apparatus and method are disclosed. In an embodiment, an audio analysis device is provided. The audio analysis device is configured to receive administrator criteria that specifies an alarm event handling response, obtain an audio file associated with a monitored security environment. detect an audio anomaly in the audio file, and in response to detecting the audio anomaly, generate an audio segment based on the audio anomaly, the audio segment comprising the audio anomaly. The audio analysis device is further configured to generate metadata comprising a characteristic associated with the audio segment, determine that the administrator criteria specifies providing the audio segment and the metadata in an agent portal, and in response to the administrator criteria, encode the audio segment and the metadata for rendering in the agent portal.

Abstract: The disclosure relates to embodiments of optical measurement systems that are configured to perform spectroscopic measurements. The optical measurement systems are configured to provide compact arrangements for introducing light into a sample and collecting light returned from the sample. Reducing the size of the launch and/or collection architecture of an optical measurement system may make the overall optical measurement system smaller, thereby providing flexibility in integrating an optical measurement system into various form factors.

Abstract: The disclosure configures a memory sub-system controller to store random data in a different layout from sequential data. The controller receives a request to store a set of data to a set of memory components. The controller determines whether the set of data corresponds to either sequential data or random data and selects a write cursor from a plurality of write cursors to associate with the set of data in response to determining whether the set of data corresponds to the sequential data or the random data. The controller programs the set of data to one or more of the set of memory components according to a data layout associated with the selected write cursor.

Abstract: An optical filter may reduce the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to cells in the human eye in certain wavelengths, such as 480 nm and 590 nm, and a visual spectral response of the human eye. The optical filter may disrupt the isomerization of melanopsin in the human eye reducing the availability of the active isoform, whereas the attenuation of light weighted across the action potential spectrum of the active isoform attenuates the phototransduction cascade leading to photophobic responses. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light in certain wavelengths, and to transmit more than a second amount of light weighted across the visual spectral response. Methods of use and methods of manufacturing optical filters are also described.

Abstract: The electric vehicle that may comprise an electrical power system that includes a first DC link; a first swappable battery in electrical communication with the first DC link, and a second swappable battery substantially the same as the first swappable battery. The first swappable battery is configured to provide power to the electric vehicle during normal operation of the electric vehicle and to at least a first operation of the electric vehicle while the second swappable battery is removed from the electric vehicle and replaced. The second swappable battery is substantially the same as the first swappable battery and disposed on the electric vehicle, the second swappable battery configured to provide power to the electric vehicle during normal operation of the electric vehicle and to at least a second operation of the electrical vehicle while the first swappable battery is removed from the electric vehicle.

Abstract: The invention provides a compound of formula (I): or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 have any of the values described in the specification, as well as compositions comprising a compound of formula (I) or a prodrug thereof, or a pharmaceutically acceptable salt thereof. The compounds are agonists of glycolytic enzyme phosphofructokinase-1 liver type and are useful for treating diseases associated with the activity of glycolytic enzyme phosphofructokinase-1 liver type, such as cancer, diabetes, sepsis, and septic shock.

Abstract: A notch finding station includes a sensor to generate a signal that depends on an proportion of a sensing region of the sensor that is covered by the substrate, and a controller. The controller is configured to cause an actuator to position a carrier head relative to the sensor such that the sensing region of the sensor is at an edge of the substrate, cause the motor to generate rotational motion such that the sensing region of the sensor scans along a circumference of the substrate, and detect an angular position of a notch in the edge of the substrate based on a signal from the sensor, including compensating for a sinusoidal component of the signal resulting from an offset of the center of the substrate from the axis of rotation.

Abstract: A method for reducing sequencing by synthesis cycle time using a microfluidic device is provided. The microfluidic device comprises a flow cell having an inlet port, an outlet port, and a flow channel extending between the inlet port and the outlet port, wherein the flow channel receives an analyte of interest and one or more reagents for analyzing and detecting molecules. To aid in the acceleration of the reactions, the microfluidic device comprises a mixing device to increase the rates of diffusion of the reagents from the fluid bulk to an active surface of the flow cell. The mixing device comprises at least one of an electrothermal mixing device, an active mechanical mixing device, and a vibrational mixing device.

Abstract: The disclosed method may include receiving laser light from a laser light source. The method may also include directing and distributing the laser light onto a laser-based panel display to render pixels having a reduced spatial coherence and a preserved pixel pitch. For example, the pixels may be rendered as a result of an optical path distance between the pixels being greater than a coherent length of the laser light. Alternatively or additionally, the pixels may be rendered as a result of incoherent addition of light from at least one of multiple ports or multiple sources. Alternatively or additionally, the pixels may be rendered as a result of active modulation of the laser light. Alternatively or additionally, the pixels may be rendered as a result of quasi-random placement of outcoupling elements. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.