Abstract: Disclosed are devices, system and methods for spinal implants to be deployed into an intervertebral space between adjacent vertebrae to replace the function of the intervertebral disc and the facets, while restoring stability, flexibility, coronal alignment/balance, sagittal alignment/balance and proper biomechanical motion.

Abstract: Systems and methods for real-time detection and mitigation anomalous behavior of a remote vehicle are provided, e.g., vehicle behavior that is consistent with distracted or unexpectedly disabled driving. On-board and off-board sensors associated with a subject vehicle may monitor the subject vehicle's environment, and behavior characteristics of a remote vehicle operating within the subject vehicle's environment may be determined based upon collected sensor data. The remote vehicle's behavior characteristics may be utilized to detect or determine the presence of anomalous behavior, which may be anomalous for the current contextual conditions of the vehicles' environment. Mitigating actions for detected remote vehicle anomalous behaviors may be suggested and/or automatically implemented at the subject vehicle and/or at proximate vehicles to avoid or reduce the risk of accidents, injury, or death resulting from the anomalous behavior. In some situations, authorities may be notified.

Abstract: A method for verification of a data value via a Merkle root includes: storing, in a memory of a processing server, a Merkle root; receiving at least a data value, a nonce, and a plurality of hash path values; generating a combined value by combining the data value and the nonce; generating a first hash value via application of a hashing algorithm to the combined value; generating a subsequent hash value via application of the hashing algorithm to a combination of the first hash value and a first of the plurality of hash path values; repeating generation of the subsequent hash value using a combination of the next hash path value of the plurality of hash path values and the most recent subsequent hash value; and verifying the data value based on a comparison of the Merkle root and the last generated subsequent hash value.

Abstract: Compositions, devices, and methods relating to the use of mixed-matrix membranes containing metal-organic frameworks to separate gases are generally described. In some embodiments, branched nanoparticles made at least in part of metal-organic frameworks are described. In some embodiments, the morphology and size of the branched nanoparticles are controlled by the presence of a chemical modulator during synthesis. In some embodiments, the branched nanoparticles are uniformly distributed in a mixed-matrix membrane. In some embodiments, the mixed-matrix membrane is configured to separate one or more gases from a gas mixture. In some embodiments, the branched nanoparticles contribute at least in part to an increase in permeability, selectivity, and/or resistance to plasticization of the mixed-matrix membrane.

Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the pancreas using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating pancreatic cancer comprising administering TLR agonists to the pancreas.

Abstract: A copolyamide composition comprising a statistical copolyamide containing 70-99 wt % of diamine and dicarboxylic acid repeat units and 1-30 wt % of lactam or AA-BB repeat units, whereby incorporation of the comonomer lactam or AA-BB unit reduces the crystallization rate (longer crystallization times) while maintaining (1) high melting point, (2) low potential plate out, (3) low oxygen permeation, (4) high tensile strength and (5) puncture/tear resistance.

Abstract: A method of forming a structure on a substrate is provided. The method includes depositing a dipole dopant containing (DDC) layer including a dipole dopant on a first and second region of a dielectric layer (DL) of the substrate. A hardmask (HM) is deposited over the DDC deposited on the first and the second regions. A patterned photoresist layer (PR) is formed over the HM. The PR includes a first portion that is positioned over the first region and an opening that is positioned to expose a portion of the HM that is disposed over the second region of the substrate. The HM and DDC within the second region are etched and at least a portion of the DL is exposed within the second region. The PR is removed and the substrate is annealed to diffuse the dipole dopant into a portion of the DL disposed in the first region.

Abstract: A tester apparatus is described. Various components contribute to the functionality of the tester apparatus, including an insertion and removal apparatus, thermal posts, independent gimbaling, the inclusion of a photo detector, a combination of thermal control methods, a detect circuitry in a socket lid, through posts with stand-offs, and a voltage retargeting.

Abstract: A gas turbine engine including a compressor section and a combustion section in serial flow arrangement along an engine centerline, the combustion section having a combustor liner, a dome wall coupled to the combustor liner, and a dome inlet located in the dome wall, a fuel injector fluidly coupled to the dome inlet, a combustion chamber fluidly coupled to the fuel injector and defined at least in part by the combustor liner and the dome wall, and at least one set of dilution openings located in the dome wall and fluidly coupled to the combustion chamber.

Abstract: The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

Abstract: Described herein are viral vaccine compositions for inoculating a subject against a coronavirus, an influenza virus, or both. The viral vaccine compositions may contain coronavirus antigens, influenza virus antigens, or both to elicit a sustained immune response in the subject. A viral vaccine may be formulated for nasal delivery. Also described herein are methods of administering viral vaccine compositions to a subject to prevent a coronavirus infection, influenza, or both. The viral vaccine compositions may be administered intranasally and may elicit an antigen-specific mucosal immune response in the subject.

Abstract: Disclosed are systems, methods and devices for a surgeon to carryout different spinal methods using a robotic and/or navigational assistance to increase the accuracy of surgical access to the targeted vertebral segment, vertebral bony preparation, selecting the proper implant size and/or implant positioning, which will optimize the restoration of spinal alignment and/or range of motion to a desirable degree.

Abstract: An engine can utilize a combustor to combust fuel to drive the engine. A fuel nozzle assembly can supply fuel to the combustor for combustion or ignition of the fuel. The fuel nozzle assembly can include a swirler and a fuel nozzle to supply a mixture of fuel and air for combustion, which can supply a primary fuel supply and a secondary fuel supply. Increasing efficiency and reducing emission require the use of alternative fuels, which combust at higher temperatures or burn at faster burn speeds than traditional fuels, requiring improved fuel introduction without the occurrence of flame holding or flashback.

Abstract: Polypeptides, nucleic acids, and compositions thereof are provided that include a targeting moiety. The polypeptides, nucleic acids, and compositions that comprise them, can be used in methods to treat subjects, to alter CAR-expressing cells in subjects who may suffer from a disease such as a cancer or a pathogen.

Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating metastases of uveal melanoma of the liver comprising administering TLR9 agonists to the liver.

Abstract: Disclosed are systems, devices, methods and surgical procedures for altering and/or correcting the alignment of adjacent bones, including bones of the spine.

Abstract: A storage apparatus has first and second bins with configurations that match. The bins have movable supports that enable the bins to be stacked on each other and attached to each other when employing the bins to store items in the bins and move the items from one area to another by moving the attached bins. The first and second bins are also nestable together to store the bins in a minimum of storage space when the bins are not in use.

Abstract: A system for enabling communication between blockchains on heterogeneous blockchain networks. The system can include a sending blockchain network comprised of a sending blockchain that includes a plurality of blocks, each block including a block header and one or more transaction values associated with an identification request transmitted by the sending blockchain. The system can include a directory service node configured to receive the identification request from the sending blockchain, and identify a receiving blockchain, which forms part of a receiving blockchain network. The system can include an identity service node configured to receive a trust request from the directory service node to determine whether a valid trust certificate is available for the receiving blockchain and enable communication between the sending blockchain and the receiving blockchain, when the valid trust certificate is determined to be available.

Abstract: Lights with features for underwater use that provide tailored beam-width and/or other tailored light patterns are disclosed. One embodiment includes a housing having a front end with a port and a back end, a port window having a plurality of lens features positioned at the front end of the housing within or behind the port, and a circuit element, including a plurality of LED lighting elements, positioned behind the window.

Abstract: Light energy is applied externally to a patient's head, neck, or both, to treat the brain and nervous system. The light energy stimulates different neurological pathways, reduces inflammation, stimulates mitochondria function in the brain, and increases HRV. The light is applied to the patient on the skull, near the vagus nerve, or a combination thereof. The treatment can be enhanced by activating the cranial nerves while the light is applied. The wavelengths of the applied light range from ultraviolet to far infrared, and preferably are visible light from about 400-760 nm. In a preferred embodiment the applied light is in the red range and more preferably about of 635 nm±10 nm. The applied light energy is applied with a pulse frequency or frequencies that mimic healthy brain function of alpha, beta, delta, and theta waves such as 8 Hz, 53 Hz, 73 Hz and 101 Hz. The pulse frequencies can be applied singularly, serially, alternately, or simultaneously.