Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

Abstract: A method (300) for detecting one or more caries using an imaging device (10), the method including the steps of: (i) directing (320) light from a first light source (12) toward a tooth (40); (ii) measuring (340), with an optical sensor (16), transmission of light from the first light source through the tooth; (iii) directing (330) light from a second light source (14) toward the tooth, wherein the second light source directs light at the tooth at a different angle relative to the first light source; (iv) measuring (350), with the optical sensor, reflectance from the tooth of light from the second light source; (v) comparing (360) the measured transmission to the measured reflectance; and (vi) determining (370), based at least in part on said comparison, whether a caries is present in the tooth.

Abstract: An apparatus for thermal interface material detection includes a heat dissipating device stack up that includes a heat dissipating device, a thermal interface material, a heat generating component, and a printed circuit board. The heat dissipating device is disposed on the thermal interface material, the thermal interface material is disposed on the heat generating component, and the heat generating component is disposed on the printed circuit board. A channel in a body of the heat dissipating device includes an embedded conductive probe, where a first end of the embedded conductive probe leads to a lower surface of the body of the heat dissipating device and a second end of the embedded conductive probe leads to an upper surface of the body of the heat dissipating device.

Abstract: A method for localizing gingival inflammation using an oral care device, comprising: (i) simultaneously emitting (520) light by a plurality of light sources (48) of the oral care device, wherein at least some of the plurality of light sources emit light of different wavelengths to result in a plurality of emitted light wavelengths, wherein each of the different wavelengths is modulated with a distinct code; (ii) obtaining (530), by a light detector (40) of the oral care device, reflectance measurements from a location within the user's mouth to generate reflectance data for the location; (iii) demodulating (540), by a controller (30) of the oral care device, the obtained reflectance data; and (iv) determining (560), by the controller using the demodulated reflectance data, whether gingiva at the location is inflamed.

Abstract: Embodiments of the disclosure provide a test article for additive manufacture and related methods. A test article formed may include a body having a forward face and a rearward face horizontally opposite the forward face. A first surface extending between the forward face and the rearward face of the body may include a plurality of protrusions for removable coupling of the body to a build plate. A second surface on the body may extend between the forward face and the rearward face of the body, and may include a plurality of angled flat surface portions. Each of the plurality of angled flat surface portions may have a distinct angle with respect to a horizontal plane of the body. An angular difference between each adjacent angled flat surface portion in the plurality of angled flat surface portions is substantially uniform.

Abstract: A method for confirmation of an electronic transaction using a blockchain includes: receiving transaction data, the transaction data including a transaction amount and currency code; generating a transaction message formatted based on one or more standards including a first data element configured to store the transaction amount, a second data element configured to store the currency code, and a third data element configured to store an invoice identifier; transmitting the transaction message to a financial institution via a payment network; receiving a return message from the financial institution via the payment network formatted based on the one or more standards and including a data element configured to store the transaction amount, currency code, and invoice identifier; and generating a hash value based on application of hashing algorithms to the transaction amount, currency code, and invoice identifier stored in the data element included in the received return message.

Abstract: An aerosol medicament delivery adapter comprises a first conduit, second conduit and a diverter element. The first conduit encloses a flow path chamber and extends between an upstream first end and a downstream second end. The second conduit comprises an aerosol medicament delivery conduit that includes an upstream first end adapted to be fluidly coupled to a particle generator, and a downstream second end luidly coupled to the first conduit at a Y-junction proximate the upstream first end of the first conduit. The diverter element comprises a flow diverter chamber disposed within the first conduit or the second conduit. The cylindrical flow diverter chamber includes a transitional flow cross-section and a principal axis, extending between a first end and a second end thereof. The diverter element creates flow eddies for enhancing an entrainment of aerosol particles, delivered via the second conduit, within a pressurized gas flow along the flow path within the first conduit.

Abstract: A method for localizing gingival inflammation using an oral care device, comprising: emitting (520) light by one or more light emitters (42) of the oral care device; obtaining (530), at a first rate by one or more light detectors (40), reflectance measurements for a plurality of locations to generate first reflectance data; determining (540), by a controller (30) of the oral care device using the first reflectance data, whether the location comprises gingiva; obtaining (550), at a second rate by the one or more light detectors, reflectance measurements for each location determined to comprise gingiva to generate gingiva reflectance data, wherein the second rate is faster than the first rate; and determining (560), by the controller using the gingiva reflectance data, whether gingiva at that location is inflamed.

Abstract: A Multi-Phase Simulation Environment (“MPSE”) is provided which simulates the conductor current and voltage or electric field of multiple phases of an electrical power distribution network to one or more sensing or measuring devices and includes independent control of wireless network connectivity for each sensing or measuring device, independent control of GPS RF to each device, and interface to a back-end analytics and management system.

Abstract: Methods and systems for protecting a secure computing system. Aspects include connecting a pluggable security card to a motherboard of the secure computing system. Aspects also include activating a detection circuit to monitor a physical connection between the pluggable security card and the motherboard. Based on detecting that the physical connection between the pluggable security card and the motherboard has been interrupted, aspects include setting a tamper event flag, wherein the secure computing system is prevented from being operated when the tamper event flag is set.

Abstract: The present invention relates to systems for use for radio frequency ablation. The systems can include one or more of an ablation tool, power source for use with the ablation tool and a backstop for use in conjunction with the ablation tool during surgical procedures. Preferred ablation tools comprise a series of three or more blade-shaped electrodes disposed in a linear, curved, curvilinear or circular array. The backstops are useful for reducing direct physical and thermal heat transfer injuries to the patient or surgeon during procedures using radiofrequency (RF) ablation devices.

Abstract: Medical breathing tubes have a tubular body that defines a lumen extending between open terminal ends of the tubular body. An internal form is enclosed within the lumen and supportive of the tubular body. The internal form may be a coated encapsulated internal form where the coating secures the internal form to the tubular body. The internal form may provide for a series of alternative crests and troughs of the tubular body. A patient interface and/or a securement system may be attached to the tubular body.

Abstract: A system for wireless power transfer to a mobile robot is presented. The system includes one or more mobile robots including a permanent magnet and at least one pair of receiving coils. The system further includes a magnetic track including a plurality of transmitting coils configured to receive power from a power supply. The system further includes a control system configured to control the power transmitted from the power supply to the plurality of transmitting coils. The control system is further configured to selectively control the plurality of transmitting coils to: simultaneously provide propulsion to a mobile robot of the one or more mobile robots moving along the magnetic track and wirelessly transfer power to the mobile robot, or switch from providing propulsion to a mobile robot of the one or more mobile robots moving along the magnetic track to wirelessly transferring power to the mobile robot.

Abstract: A method (500) for localizing gingival inflammation using an oral care device (10), the method comprising: (i) emitting (520) light at a first intensity by a light emitter (42); (ii) obtaining (530) first reflectance measurements reflectance data; (iii) determining (540), by a controller (30) from the first reflectance data, whether the location comprises gingiva; (iv) automatically adjusting (550), based at least in part on the first reflectance data, the intensity of a light emitter to a second intensity different from the first intensity, and/or automatically adjusting (550) a gain of a light detector; (v) obtaining (560) a second plurality of reflectance measurements by the light detector of the oral care device for at least some of the locations; and (vi) determining (570), using the second plurality of reflectance measurements, whether gingiva at the location is inflamed.

Abstract: A method for processing votes in a public blockchain includes: generating an election reference and candidate references; generating an asymmetric cryptographic key pair comprised of a master private key and master public key; generating a registration block for addition to a blockchain including the election reference, candidate references, and master public key; transmitting the registration block to nodes associated with the blockchain; receiving a plurality of voting messages, each including a vote and the election reference, where the vote includes a voter reference and at least one candidate reference; generating one or more voting blocks for addition to the blockchain including the received votes; and transmitting each generated voting block to nodes associated with the blockchain.

Abstract: A method for processing a guaranteed electronic transaction, includes: storing account profile, each include an account number and balance; receiving a transaction message from an acquiring financial institution via a payment network, the message including a specific account number, transaction amount, and payment guarantee data; identifying a specific account profile that includes the specific account number; deducting the transaction amount from the account balance in the specific account profile; generating a record of payment guarantee that includes the transaction amount and data associated with the payment guarantee data; generating a return message including a response code indicating transaction approval and data associated with the generated record; transmitting the generated record to a computing system via a communication network; and transmitting the generated return message to the acquiring financial institution via the payment network.

Abstract: An elastomeric feed port and a bird feeder having a seed reservoir with a seed opening fitted with such an elastomeric feed port is provided. The feed port has an elastomeric seed control membrane with a cutout that forms at least one aperture through which birds can access seed in the reservoir. The cutout is shaped to create flexible flaps or fingers adjacent the aperture in the membrane that partially cover the seed opening to reduce seed spillage but that can be pushed aside or temporarily deformed by a bird when the bird inserts its beak into the cutout aperture to access seed therethrough.

Abstract: Embodiments of the invention relate to a computer-implemented method and system for generating personalized recommendations for a target user based at least on stored data about the target user. The method comprises obtaining, at the server computer, data from a plurality of data sources, including entity data associated with a plurality of entities, stored in an entity database, or personal data associated with a plurality of users, stored in a user database. The personalized recommendations system then merges the entity data or personal data and maps the entity or personal data to a corresponding entity or target user, respectively. The entity or personal data is differentiated, a relevance is determined, a weight is assigned to the data and corresponding source to canonicalize the data, the respective databases are updated with the corresponding data, and then a set of personalized recommendations to the target user is generated using the updated databases.

Abstract: Implantable devices for fixation of curved bone such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state, and include an elongate structure having a proximal bone interface, a main body, and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.

Abstract: Various embodiments of the present disclosure describe a diversion device that traps an initial flow of blood in a diversion chamber of the diversion device. The diversion device comprises a housing having an inlet conduit and an outlet conduit; a diversion chamber that comprises a flow path defined by a channel or series of channels that terminate in a diversion chamber valve; a collected sample valve; and bypass flow chamber positioned within the housing, wherein the collected sample valve is configured to permit subsequent flow of fluid to enter the bypass flow chamber, and the bypass flow chamber is configured to permit the subsequent flow of fluid to exit the diversion device. The diversion chamber valve allows air, but not blood, to flow through it.