Abstract: An apparatus for physically securing a tablet and a keyboard includes a main body, a left arm, a right arm a front arm and a top arm. The front arm extends from the main body to secure the front of the keyboard and has a first latching ratchet mechanism that prevents extension of the front arm in a first configuration of the first latching ratchet mechanism and enables extension of the front arm in a second configuration of the first latching ratchet mechanism. The top arm has a second latching ratchet mechanism that prevents extension of the top arm in a first configuration of the second latching ratchet mechanism and enables extension of the top arm in a second configuration of the second latching ratchet mechanism.

Abstract: PGM converting process and jacketed rotary converter. The process can include low- or no-flux converting; partial pre-oxidation of PGM collector alloy; using a refractory protectant in the converter; magnetic separation of slag; recycling part of the slag to the converter; smelting catalyst material in a primary furnace to produce the collector alloy; and/or smelting the converter slag in a secondary furnace with slag from the primary furnace. The converter can include an inclined converter pot mounted for rotation; a refractory lining; an opening in a top of the pot to introduce converter feed; a lance for injecting oxygen-containing gas into the alloy pool; a heat transfer jacket adjacent the refractory lining; and a coolant system to circulate a heat transfer medium through the jacket to remove heat from the alloy pool in thermal communication with the refractory lining.

Abstract: A hot melt adhesive composition comprises a polymer comprising poly(?-methyl-?-propiolactone) (PMPL) or a derivative thereof, wherein the PMPL is polymerized from a plurality of (R)-?-methyl-?-propiolactone monomers and a plurality of (S)-?-methyl-?-propiolactone monomers, wherein the ratio of (R):(S) monomers is from about 90:10 to about 10:90. Changing the (R):(S) ratio impacts the isotactic diad fraction and consequently the crystallinity and thermomechanical properties of the resulting PMPL. The PMPL may be hydroxyl-terminated, with the residue thereof serving as the elastomeric B block in an A:B:A triblock copolymer having hard end A blocks, such as a residue of polylactic acid. The PMPL diol may also be used as a reactant to form an alkoxysilane-terminated polymer, a polyurethane, or a (co)polyester. In some embodiments, such triblock polymers may be entirely bio-sourced and compostable.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: Some embodiments provide an irrigation flow sensor system, comprising: a housing forming a fluid channel to cooperate with conduits of an irrigation system; a paddle wheel device with at least a first blade of a set of the blades comprises a magnetic element; the paddle wheel device is positioned with at least a portion of the blades extends into the fluid channel as the blades rotate about an axis; a magnetic sensor proximate a pathway of the magnetic element as it rotates configured to provide a sensor output every time the magnetic element passes the magnetic sensor; a switch coupled to the magnetic sensor and a current loop, wherein the switch in an activate state is configured to temporarily change the current in the current loop in response to the sensor output, with a rate of change in current corresponding to a flow rate of the fluid flowing.

Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Abstract: A patient immersion sensor includes a radio detection and ranging (RADAR) apparatus to determine a time of flight (TOF) of a RADAR pulse and a reflected signal that is reflected by a patient or by a portion of a patient support surface supporting the patient. The TOF is indicative of an immersion depth or a distance toward bottoming out of a patient supported on the patient support surface, such as a mattress or a pad. The RADAR apparatus emits pulses of very short duration so as to be able to detect objects, such as a patient or a portion of a mattress or pad, at very close distances. The RADAR apparatus may use time-of-flight (TOF) between transmission of the pulse and receipt of a reflected signal to determine a distance toward bottoming out by the patient, thereby to determine if the patient is properly immersed into the patient support surface.

Abstract: A hot melt adhesive composition comprises a polypropylene homopolymer having a DSC melting point of less than 100° C.; a butene-based copolymer; and a plasticizer. The butene-based copolymer may comprise a butene-rich amorphous poly-alpha olefin, such as a butene-propylene copolymer, or a semi-crystalline copolymer, such as a butene-ethylene copolymer. The hot melt adhesive is especially useful for bonding substrates which swell or elongate significantly in use. Such uses include adhering superabsorbent polymers to a substrate or adhering together two substrates at least one of which having superabsorbent polymers, such as the top and bottom layer of an absorbent core of a disposable hygiene article, such as a diaper, feminine sanitary napkin, and adult incontinence pad. The hot melt adhesive composition, which does not contain a tackifier, demonstrates suitable elongation at break and stress at yield, with a sufficiently low viscosity, to stabilize an absorbent core having superabsorbent polymers.

Abstract: A flattened expanded metal strip (9) is wrapped into an airbag inflator filter (21) with the strip oriented such that the flattened rough side (17) of the strip is pointing toward the inside diameter (ID) of the filter and the flattened smooth side (15) is pointing towards the outside diameter (OD). With this orientation, the filter (21) is able to capture more slag than filters made using the standard wrapping method in which the smooth side is oriented inward. The expanded metal can be of various types including, for example, variable expanded metal (VEM) or standard expanded metal (SEM).

Abstract: A spiral wound membrane module including a specialized endcap assembly including a connecting conduit defining a passageway extending radially inward from its outer periphery, and a differential pressure sensor connected to the passageway of the connecting conduit.

Abstract: A multi-element filtration vessel included spaced beams for supporting and/or aligning filtration elements from below. The filtration elements have bottom ends adapted to rest upon adjacent support beams and also to extend between them to form a cavity that can capture feed fluid and an aeration gas and conduct it into the filtration element. In another aspect, a multi-element filtration vessel has removable aerators mounted on a projection on the wall of the filtration vessel.

Abstract: The dosages and methods described herein provide desirable pharmacokinetic (PK) and pharmacodynamics (PD) characteristics which inhibit alternative pathway complement activity, for example at least 85% or more inhibition of AP activity in vivo at dosages from about 120 mg to 200 mg BID that provides a plasma level Ctrough at least about 65 ng/ml, which provides sufficient AP inhibition to reduce the risk of complement breakthrough. In addition, the dosage form described herein provides a significantly low Cmax, providing additional safety margin and better dosing flexibility.

Abstract: This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system.

Abstract: A novel catheter is disclosed comprising an electrode array that is capable of switching between a sensing configuration for sensing electrical signals of biological tissue and an ablation configuration for delivery of ablation energy at a region of interest. Irrigation ports are interlaced within the electrode array to vent irrigant during an ablation procedure to; prevent excessive heating, charring of tissue, coagulation of blood, and allow for efficient delivery of ablation therapy for maximum therapy efficacy. The novel catheter includes a plurality of splines with linear portions wherein the electrodes of the electrode array are disposed. The splines are connected by connectors which include one or more bends capable of storing potential energy when the bends are elastically deformed, enabling collapse and expansion of the catheter in a sheath.

Abstract: The present invention provides a prosthetic heart valve device with improved fit and/or apposition between the device frame and left atrial tissue and/or the device base and the annular tissue of the left atrium to improve shifting of the implanted device and/or mitigate paravalvular leakage. The improved fit and/or apposition arises in various embodiments by providing or allowing an asymmetrical frame and/or frame base and/or providing a lower lip to aid in conforming to the asymmetrical shape of the atrium and/or ensure firm positioning therein. An additional benefit of these arrangement(s) is mitigation of paravalvular leakage as a result of improved fit and seal. In certain embodiments, the asymmetry of the frame assists with delivery of the device into the atrium.

Abstract: An example device for measuring a digital capillary refill time (CRT) can include a wearable component, a processor, and an output. The wearable component includes a touch pressure element and an optical sensor capable of transmitting and detecting optical energy. The detector converts the received optical energy into an electrical signal that represents the optical energy incident on the optical detector. The processor is programmed to receive the electrical signal from the detector, determine the CRT based on the optical sensor data, and output the electrical signal or the determined CRT.

Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Abstract: This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.

Abstract: An iterative attention-based neural network training and processing method and system iteratively applies a focus of attention of a trained neural network on syntactical elements and generates probabilities associated with representations of the syntactical elements, which in turn inform a subsequent focus of attention of the neural network, resulting in updated probabilities. The updated probabilities are then applied to generate syntactical elements for delivery to a user. The user may respond to the delivered syntactical elements, providing additional training information to the trained neural network.