Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Abstract: A load securing device for securing a load such as a pallet within a container such as a cargo trailer so as to prevent the load from side-to-side shifting or jostling. The load securing device includes an inner support telescopically connected to an outer support. The inner support includes a first brace and the outer support includes a second brace. The inner and outer supports each include a ratchet for drawing the supports towards or away from each other so as to lengthen or shorten the effective length of the load securing device. A handle is connected between the first and second ratchets so that the handle may adjust the ratchets. A locking device is included for selectively locking the handle in place to prevent further adjustment of the supports. The braces may be secured between a load and a container to secure the load within the container.

Abstract: In one aspect, an example method includes (i) identifying, by a playback device, a media device that provides media content to the playback device; (ii) providing, by the playback device, replacement media content for display; (iii) determining, by the playback device, that while the playback device is displaying the replacement media content a remote control transmitted an instruction to the identified media device; (iv) determining, by the playback device, a playback-modification action corresponding to the instruction and the identified media device; and (v) modifying, by the playback device, playback of the replacement media content in accordance with the playback-modification action.

Abstract: A light-absorbing, neutral density filter for an electronic device display having a capacity grid layer. More specifically, a light-absorbing, neutral density filter applied as a protective film or protective layer to an electronic device display or incorporated into or onto the screen layers of a device that can block ultraviolet light, high energy visible light, a portion of blue light, and/or other light in the visible spectrum. The neutral density filter comprises a polymer substrate and an absorbing agent.

Abstract: A micro-channeling system, the system includes a micro-channeling device, a needle tip connector and a variety of micro-needling assemblies. The micro-channeling device is designed to provide reciprocal motion, in and out of skin, for the micro-needling assemblies when applied to skin. A quick connector is provided for easy interchange of the micro-needling assemblies. Benefits of the system include ergonomic holding, versatility of needle arrays and reduced vibration.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for dynamic volume adjustment via audio classification.

Abstract: A robot leg assembly including a hip joint and an upper leg member. A proximal end portion of the upper leg member rotatably coupled to the hip joint. The robot leg assembly including a knee joint rotatably coupled to a distal end portion of the upper leg member, a lower leg member rotatably coupled to the knee joint, a linear actuator disposed on the upper leg member and defining a motion axis, and a motor coupled to the linear actuator and a linkage coupled to the translation stage and to the lower leg member. The linear actuator includes a translation stage moveable along the motion axis to translate rotational motion of the motor to linear motion of the translation stage along the motion axis, which moves the linkage to rotate the lower leg member relative to the upper leg member at the knee joint.

Abstract: An expandable and collapsible stent comprising prosthetic leaflets attached to an inner valve support section that extends radially upward into an outer stent section. A transition stent section is disposed between the inner valve support section and the outer stent section. Each of the outer stent section, the inner valve support section and the transition stent section may comprise struts or the equivalent that form and define cells having a pattern, wherein each section may comprise a different cell pattern. Transition stent section preferably comprises struts that are of equal curvature, with adjacent struts equally spaced from each other to allow nested collapsing of the transition stent section struts. A boss section extending downstream away from the inner valve support section may be provided to aid in alignment and retention of the expanded stent and may comprise a shape that is complementary to a heart chamber annulus.

Abstract: A surgical stapler for applying a suture to tissue includes a first jaw and a second jaw configured to receive a cartridge. An actuation mechanism translates a drive member distally through the first and second jaws to apply staples to tissue such that a suture, in combination with the staples, forms a purse string when the stapler activated. The cartridge includes a first upper portion and a second lower portion.

Abstract: Disclosed are approaches to determining a sensitivity of a bacterium to a given antibiotic and generating targeted treatments based on the sensitivity. One or more antibiotics may be selected for a chronic/recurrent infection resulting from a biofilm so as to reduce dose and or length of course of antibiotic treatment. For example, if a bacterial pathogen is determined to be sensitive to an antibiotic in its planktonic form but resistant to that antibiotic in its biofilm form, then the biofilm may be dispersed or disrupted from the biofilm residence in order to clear the infection. In various embodiments, a dispersal or disruption method and/or agent may be determined based at least in part on a rate of bacterial release from a biofilm that sensitizes the pathogen to a chosen antibiotic.

Abstract: Apparatuses for physically securing a laptop in an open position to a display surface are disclosed. Such an apparatus comprises a main body from which fastener(s) extend downward, and left and right arms that are extendable and retractable relative to the main body. The left and right arms comprise, respectively, left and right braces. A tab extends through an opening in a bottom of the main body and is configured to transition the apparatus from a unidirectional configuration to a bidirectional configuration in response to being pressed. When the apparatus is in the unidirectional configuration the left and right arms are retractable in tandem relative to the main body, and the left and right arms are prevented from being extended relative to the main body. When the apparatus is in the bidirectional configuration the left and right arms are both retractable and extendable relative to the main body.

Abstract: Systems and methods are described for denoising, or filtering out, unwanted noise or interference, from biological or physiological parameter signals or waveforms such as ECG signals caused by application of electromagnetic energy (e.g., electrical stimulation) in a vicinity of sensors configured to obtain the biological or physiological parameter signals.

Abstract: One or more radar sensors can be used to monitor patients in a variety of different environments and embodiments. In one embodiment, radar sensors can be used to monitor a patient's movement, including movement in a patient bed and around a room. In another embodiment, a patient position can be monitored in a patient bed, which can be used as feedback for control of bladders of a patient bed. Additional embodiments are described herein.

Abstract: A method of facilitating therapeutic neuromodulation of a heart of a patient includes positioning an electrode in a pulmonary artery, positioning a sensor in vasculature, delivering via a stimulation system first and second electrical signals of a series of electrical signals to the electrode. The second electrical signal differs from the first electrical signal by a magnitude of a first parameter of a plurality of parameters. The method includes determining, via the sensor, sensor data indicative of one or more heart activity properties in response to the delivery of the series of electrical signals, and delivering a therapeutic neuromodulation signal to the pulmonary artery using selected electrical parameters. The selected electrical parameters include a selected magnitude of the first parameter. The selected magnitude of the first parameter is based at least partially on the sensor data. The therapeutic neuromodulation signal increases heart contractility.

Abstract: Apparatus and associated methods relate to remote priming of a texture sprayer. The texture sprayer includes a main unit, a hose assembly and a spray gun, the main unit includes an air compressor, a sensor that senses a parameter of air compressed by the air compressor, and a texture material pump that is activated and deactivated in response to the parameter sensed. A spray gun can be remoted coupled to the main unit via the hose assembly. The spray gun includes a nozzle, from which the texture material is forcefully expelled as a spray, a trigger, and a prime valve. Actuation of the trigger causes the spray gun to mix the compressed air with the texture material and to forcefully expel the texture material as a spray from the nozzle, thereby causing flow of the compressed air. Opening the prime valve releases the compressed air thereby causing flow of the compressed air.

Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.

Abstract: A method of optimizing coil designs in a three-phase dynamic wireless power transfer (DWPT) system is disclosed which includes A) providing a plurality of variables associated with coil designs along with valid ranges for each variable, B) providing a plurality of constant parameters associated with the DWPT system, C) establishing a physical candidate design that has been optimized based on the variables that maximizes a magnetic coupling factor k based on a sequence-coupling factor ?, D) determining an objective function of a multi-objective optimization, E) iteratively generating, evaluating, and selecting a set of candidate designs until a converged non-dominated set of solutions is determined for the magnetic coupling factor k and the sequence coupling factor ?, and F) outputting a finalized design based on the last set of candidate designs resulting from (E).

Abstract: Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.

Abstract: This disclosure provides antibody fragments and isolated polypeptides comprising the antibody fragments that are useful as a therapeutic for those with an existing infection characterized by the formation of biofilms. Antibody fragments and isolated polypeptides comprising the antibody fragments can be administered to detect, treat, or prevent infection and/or remediate biofilms. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.

Abstract: A data system is provided for analyzing and maintaining data obtained from one or more data sources on which the data system depends. The system includes a primary database including current values used by the system and a collection of executable algorithms used to generate the data maintained in the primary database. In response to receiving a notification regarding a change in one of the data sources, a dependency database is used to establish an execution order for algorithms of the algorithm collection that are directly or indirectly dependent on the changed data. The algorithms identified in the execution order are then executed in accordance with the execution order and the corresponding result is stored in the primary database. The system may include data harvesters adapted to recognize changes in the data sources and to generate and transmit corresponding change notifications when such changes occur.