Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.

Abstract: Systems, apparatuses, and methods for efficiently driving level shifted write data are described. In various embodiments, a level-shifting write driver combines a write data bit and a write mask bit that each use a first supply voltage to indicate a logic high level. During a write operation, the driver generates complementary values on two output nodes based on the write data bit. The output nodes use a second supply voltage greater than the first supply voltage. Before a write operation, the driver precharges each of the two output nodes to the second supply voltage. When the write clock enables a write operation and the write mask bit disables the write operation, the level-shifting write driver puts the two output nodes in a tri-state.

Abstract: A prosthetic device for implanting in a patient's heart includes (i) a therapeutic device capable of restoring function to a native heart valve; and (ii) at least one sensor including a body, an inductor coil disposed within the body, and a capacitor in communication with the inductor coil, the at least one sensor being coupled to the therapeutic device, and being configured to monitor proper function of the therapeutic device within the patient's heart.

Abstract: The invention relates to methods, compositions, and kits for treating a condition with an immune response modifier and a human papillomavirus (HPV) vaccine. Conditions treatable with the methods, kits and compositions include but are not limited to neoplasia, anal intraepithelial neoplasia, high-grade squamous intraepithelial neoplasia, dysplasia, anal dysplasia, dysplastic lesion, high-grade dysplastic lesion, condyloma, anal cancer, anal tumor, HPV infection, and any HPV-induced condition.

Abstract: Systems, apparatuses, and methods for efficiently increasing reliability of memory accesses are described. In various embodiments, write data and write mask data are shifted by redundancy logic in a memory. The redundancy logic receives write data bits, which are segmented into one or more write groups in addition to one or more mask bits and one or more shift bits per write group. If the redundancy logic detects a first shift bit assigned to a first write group is asserted, then the redundancy logic selects a second mask bit assigned to a second write group different from the first write group. Otherwise, a first mask bit assigned to the first write group is selected. Following, the redundancy logic combines the selected mask bit with the first data bit of the first write group.

Abstract: Systems, apparatuses, and methods for efficiently driving level shifted write data are described. In various embodiments, a level-shifting write driver combines a write data bit and a write mask bit that each use a first supply voltage to indicate a logic high level. During a write operation, the driver generates complementary values on two output nodes based on the write data bit. The output nodes use a second supply voltage greater than the first supply voltage. Before a write operation, the driver precharges each of the two output nodes to the second supply voltage. When the write clock enables a write operation and the write mask bit disables the write operation, the level-shifting write driver puts the two output nodes in a tri-state.

Abstract: A prosthetic heart valve may include a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuff attached to the stent, and a sealing member attached to the cuff and extending from a proximal end of the cuff to a free edge. The sealing member may be movable between an extended condition in which the free edge is located proximally of the proximal end of the stent, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surface of the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing member are also described.

Abstract: A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent has a proximal end, a distal end and a plurality of cells, each cell being formed by a plurality of struts. A valve assembly is secured to the stent and includes a cuff and a plurality of leaflets. The plurality of leaflets are attached to the cuff adjacent an underwire that extends about the perimeter of the cuff.

Abstract: Systems and methods for analyzing and displaying radiofrequency (RF) information collected at a radio sensor are provided. The method can include receiving, analyzing and buffering RF signal information at a radio sensor. The radio sensor can relay the buffered signal data and related metadata to a ground station for display, review, and playback. The buffered signal data can be stored in a memory of the ground station, each RF signal of the plurality of RF signals having an associated signal data buffer in the memory. The ground station can then display activity boxes on a box display indicating an activity level or an amount of data buffered relating to an associated RF signal. The system can further display activity symbols on an activity display each activity symbol depicting a timewise display of the spectral data and/or an amount of signal data buffered.

Abstract: A prosthetic heart valve 300 may include a collapsible and expandable stent 306 having a proximal end 302, a distal end 304, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuff 312 attached to the stent, and a sealing member 322 attached to the cuff and extending from a proximal end 313 of the cuff to a free edge 323. The sealing member 322 may be movable between an extended condition in which the free edge 323 is located proximally of the proximal end 302 of the stent 306, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surface 324 of the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing member 322 are also described.

Abstract: A method includes controlling a power limit of a computing system based on a determined skin temperature of at least one location on an outer surface of a device housing the computing system. A processor includes a processing unit and a power management controller to control a power limit of the processing unit based on a determined skin temperature of at least one location on an outer surface of a device housing the processor.

Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.

Abstract: A prosthetic valve assembly for implantation in a patient's circulatory system includes a stent, a valve member coupled to the stent and defining a preferred landing zone relative to anatomical structures in the patient's circulatory system, and at least one marker positioned in a predetermined relationship relative to the landing zone of the valve member, the marker being visually distinguishable from the stent using an imaging technique. By observing the marker, the prosthetic valve assembly may be implanted in the patient so that certain ones of the anatomical structures lie within the landing zone.

Abstract: Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.

Abstract: A prosthetic valve assembly for implantation in a patient's circulatory system includes a stent, a valve member coupled to the stent and defining a preferred landing zone relative to anatomical structures in the patient's circulatory system, and at least one marker positioned in a predetermined relationship relative to the landing zone of the valve member, the marker being visually distinguishable from the stent using an imaging technique. By observing the marker, the prosthetic valve assembly may be implanted in the patient so that certain ones of the anatomical structures lie within the landing zone.

Abstract: A prosthetic heart valve 300 may include a collapsible and expandable stent 306 having a proximal end 302, a distal end 304, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuff 312 attached to the stent, and a sealing member 322 attached to the cuff and extending from a proximal end 313 of the cuff to a free edge 323. The sealing member 322 may be movable between an extended condition in which the free edge 323 is located proximally of the proximal end 302 of the stent 306, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surface 324 of the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing member 322 are also described.

Abstract: Objects can be produced using an additive manufacturing process. The objects can include a plurality of layers of a polymeric material that includes a copolyester ether. The copolyester ether can include units of a diacid component and units of a glycol component. In some implementations, the units of the diacid component can be derived from at least one aliphatic dicarboxylic acid. Further, in some illustrative examples, the units of the glycol component can be derived from an aliphatic glycol and a polyalkylene ether glycol. In some cases, the polymeric material can also include a thermoplastic elastomer and a resin component.

Abstract: A method includes controlling a power limit of a computing system based on a determined skin temperature of at least one location on an outer surface of a device housing the computing system. A processor includes a processing unit and a power management controller to control a power limit of the processing unit based on a determined skin temperature of at least one location on an outer surface of a device housing the processor.

Abstract: A method includes adjusting a maximum skin temperature threshold of a device based on a device state, adjusting a power limit for the device based on the adjusted maximum skin temperature threshold, and operating the device based on the adjusted power limit. A processor includes a processing unit and a power management controller to adjust a maximum skin temperature threshold based on a device state and adjust a power limit for the processing unit based on the adjusted maximum skin temperature threshold.

Abstract: A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent has a proximal end, a distal end and a plurality of cells, each cell being formed by a plurality of struts. A valve assembly is secured to the stent and includes a cuff and a plurality of leaflets. The plurality of leaflets are attached to the cuff adjacent an underwire that extends about the perimeter of the cuff.