Abstract: The present disclosure relates to genetically modified plants including one or more edited open reading frames (uORFs) in endogenous nucleotide sequences encoding photosystem II subunit S (PsbS), zeaxanthin epoxidase (ZEP), or violaxanthin de-epoxidase (VDE). The present disclosure further relates to methods of producing the genetically modified plants, as well as to isolated constructs and expression cassettes for use in producing the genetically modified plants. In addition, the present disclosure relates to transient screening methods to study gene expression.

Abstract: In general, the subject matter described in this disclosure can be embodied in methods, systems, and program products. A computing system causes presentation of first and second types of contact records that are available for a user-selected geographic area, along with indications of quantities of the types of contact records. User input is received that specifies amounts of the first and second types of contact records. The computing system provides contact information for the user-specified amounts of the first and second types of contact records.

Abstract: Apparatus and methods are presented for non-contact in-vivo measurement of one or more properties of a cornea or tear film with spatial resolution. In certain embodiments the cornea/tear film is probed at substantially normal incidence with a converging array of beamlets from a multi-wavelength optical source, and the reflected light analysed interferometrically to generate a time sequence of pachymetry maps. Thickness variations arising from differences between the external and intraocular pressure, e.g. from the ocular pulse or externally applied pressure changes, are measured and analysed to obtain information on a biomechanical response of the cornea. In preferred embodiments the time variation in tear film thickness is measured and subtracted to yield normalised pachymetry data for the biomechanical analysis. In certain embodiments the apparatus is configured to measure the dynamics and profile of the tear film, using either converging or substantially parallel arrays of beamlets.

Abstract: In general, the subject matter described in this disclosure can be embodied in methods, systems, and program products for linking to a search result. A computing system receives a query and provides, to a first computing device, multiple results that are responsive to the query. The computing system provides, to the first computing device, information that identifies a web address of a user selected result of multiple results that are responsive to query. The computing system receives a request from a second computing device for content responsive to the web address of the user selected result. The computing system provides, to the second computing device, information to cause the second computing device to present the multiple results that are responsive to the query in distinction to the user selected result, responsive to the second computing device not being authorized to access the user selected result.

Abstract: Examples of methods are described herein. In some examples, a method includes determining signal variation data of a fluorescence signal measured from an amplification procedure of a nucleic acid sample. In some examples, the method includes detecting, using a machine learning model, a target nucleic acid strand in the nucleic acid sample based on the signal variation data.

Abstract: A system for multiple brakes intelligently controlled by a single brake input on a personal mobility vehicle. By determining a front and rear brake differential based on the position and weight of the rider as well as the environmental and vehicle conditions, the system may reduce the risk of the vehicle skidding or tipping due to over-braking. In some embodiments, a rider may use a single brake lever to indicate a desire to brake and the system may make determinations about how to apply a combination of mechanical and electrical brakes to front and back wheels. By applying different braking systems based on a combination of controls and sensors, the system may improve user experience and user safety, especially for inexperienced riders.

Abstract: A rifle actuation mechanism is provided for alternately positioning a rifle between stowage within a cylindrical tube having a longitudinal axis and deployment for engaging a target. The mechanism includes a cradle, a yoke, and longitudinal, elevation and azimuth actuators. The cradle holds and fires the rifle. The yoke connects to the cradle. The longitudinal actuator translates the yoke along the axis. The elevation actuator pivots the cradle from the yoke. The azimuth actuator turns the cradle about the axis for pointing to the target. The tube contains the rifle, the cradle, the yoke and the actuators while in stowage. In preferred embodiments, the axis is substantially vertical.

Abstract: Apparatus and methods are presented for spectral domain optical imaging, in particular for single shot 3-D spectral domain imaging of the retina or angio-OCT applications, using an extended illumination field comprising a plurality of linearly displaced combs of wavelengths selected from across the light source bandwidth. This allows recovery of phase and amplitude information at many times the Nyquist depth, without the loss of optical power that would be incurred by traditional wavelength comb generators such as etalons. Spatially incoherent or partially spatially incoherent light sources can be used in certain embodiments. In certain embodiments a temporally modulated angular component is imposed on a short axis of the extended illumination field. In preferred embodiments light reflected or scattered from the object is sparsely sampled in the far field, e.g. at a Fourier plane, in a dimension perpendicular to the long axis of the extended illumination field.

Abstract: A perforating apparatus including: a blade support having a blade support assembly, where the blade support assembly includes: a clamp coupled to the blade support; a blade positioned between the clamp and an outer surface of the blade support; and a plurality of dampener members extending along at least a portion of a longitudinal length of the blade, where a first dampener member is positioned on a first side of the blade, where a second dampener member is positioned on a second side of the blade, and where the first side of the blade faces the blade support and the second side of the blade is opposite the first side of the blade. Also disclosed is a method for forming a line of weakness in a substrate. Also disclosed is a blade support having a corresponding blade support assembly.

Abstract: A method for securing an access to a location using a gate system including an entrance door and an exit door that opens onto the location, comprising: obtaining a number of persons who will form a group to pass through the gate system together, opening the entrance door, counting the number of persons present between the entrance door and the exit door using an overhead sensor, verifying, using biometric data, that all the persons present between the entrance door and the exit door are authorized, and triggering opening the exit door if the counted number of persons and the obtained number of persons are equal and if all the persons present in the gate system are authorized.

Abstract: A method that includes performing additive manufacturing using metal powder under a predetermined condition to manufacture an additively manufactured test object including a reference part, a deformation part and a coupling part integrating the reference part and the deformation part arranged in a surface direction of an upper surface of a baseplate on the upper surface of the baseplate such that the reference part, the deformation part, and the coupling part are joined to the upper surface of the baseplate; a separation step of separating the additively manufactured test object from the upper surface of the baseplate; and measuring the deformation amount of the deformation part based on the reference part of the additively manufactured test object separated from the upper surface of the baseplate.

Abstract: A security breach is detected on a media terminal, media recycler/dispenser, safe, and/or media cassette. A note destruction apparatus of the media cassette is activated causing the notes in the cassette to be burned, ripped, cut, sliced, and/or tom. The destroyed notes are unfit for use after activation of the note destruction apparatus of the media cassette.

Abstract: Air is pressurized in a pressurized security apparatus which surrounds a housing for a safe of a media recycler/dispenser or a housing for the media recycler/dispenser. Air pressure is monitored for the pressurized security apparatus. Air pressure that drops below a configured amount causes a security event to be sent to a security system as an indication that the safe and/or recycler/dispenser has been tampered with by unauthorized individuals. The security system initiates security actions that can include dispatching authorities to a location associated with the recycler/dispenser.

Abstract: A room manager can generate mappings for a real-world room that support a shared XR environment. For example, the real-world room can include real-world objects and surfaces, such as a table(s), chair(s), wall(s), door(s), window(s), etc. The room manager can generate XR object definitions based on information received about the real-world room, object(s), and surface(s). For example, the room manager can implement a flow that guides a user equipped with an XR system to provide information for the XR object definitions, such as real-world surfaces that map to the XR object(s), borders (e.g., measured using a component of the XR system), such as borders on real-world surfaces, semantic information (e.g., number of seat assignments at an XR table, size of XR objects, etc.), and other suitable information. Implementations generate previews of the shared XR environment, such as a local preview and a remote preview.

Abstract: A room manager can generate mappings for a real-world room that support a shared XR environment. For example, the real-world room can include real-world objects and surfaces, such as a table(s), chair(s), wall(s), door(s), window(s), etc. The room manager can generate XR object definitions based on information received about the real-world room, object(s), and surface(s). For example, the room manager can implement a flow that guides a user equipped with an XR system to provide information for the XR object definitions, such as real-world surfaces that map to the XR object(s), borders (e.g., measured using a component of the XR system), such as borders on real-world surfaces, semantic information (e.g., number of seat assignments at an XR table, size of XR objects, etc.), and other suitable information. Implementations generate previews of the shared XR environment, such as a local preview and a remote preview.

Abstract: Described herein are embodiments of a diffractive optical element (23) such as a grism. In one embodiment, the diffractive optical element (23) includes an input surface (31) configured to receive an input optical signal (29), a diffractive surface (33) adapted to spatially disperse the input optical beam (29) into a dispersed signal and an output surface (35) configured to output the dispersed signal from the diffractive optical element. The input surface (31) and the diffractive surface (33) are non-parallel and the diffractive surface (33) is formed in situ by a photolithographic technique.

Abstract: The present invention provides acyl sulfonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treatment and/or prophylaxis of diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.

Abstract: The present invention provides acyl sulfonamide compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, Ra and Rb are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treatment and/or prophylaxis of diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.

Abstract: Systems and methods for desalinating a liquid are provided. A desalination system may include a main container and may be configured to provide at least one of an electric field or a magnetic field through the main container to control a distribution of ions in a liquid in the main container.

Abstract: In one or more arrangements, a failure indication system is provided having a light assembly, a heating mat assembly and a control circuit. The light assembly is configured to project a wavelength of light that is visible to animals and that illuminates the heating mat assembly to attract an animal to the heating mat. The control circuit is configured to detect when a fault has occurred with the heating mat assembly. When the control circuit detects that a fault has occurred with the heating mat assembly, the control circuit causes the light assembly to indicate the heating mat assembly is not functioning properly.