Abstract: The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the preparation of the compound of formula (I) are also provided.

Abstract: Some computing systems and computer-implemented methods detailed herein provide an improved user interfaces to facilitate seamless management, monitoring, and selection of targeted insurance agents contracted with, or to be contracted with, particular insurance providers.

Abstract: A system for dispensing a detergent solution from a solid detergent into a dishwasher includes a dispenser that can collect water sprayed into the dishwasher and use the collected water to produce the detergent solution by dissolving a portion of the solid detergent, controlling the amount of the detergent solution produced, and releasing the produced detergent solution between cleaning cycles. The dispenser can perform these functions automatically without being electrically powered.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: Provided are compounds of formula (III), and the use of compounds of formula (III) in methods of treatment, such as methods of treating a microbial infection. The compounds of formula (III) is: where —R15 is an amino-containing group: and —R1, —R2, —R3, —R4, —R8, —RA, Q, —R16, —R17 are as described in further detail in the description.

Abstract: Various embodiments provide a hopper railroad car top hatch cover assembly including a hatch cover and a hatch cover securer configured to secure the hatch cover in a closed position engaging a coaming of the hopper railroad car. Various embodiments provide a hopper railroad car having a top hatch cover assembly including a hatch cover and a hatch cover securer configured to secure the hatch cover in a closed position engaging a coaming of the hopper railroad car.

Abstract: Described herein is a calibration system (25) for a wavelength selective switch (1). The switch (1) is adapted for dynamically switching optical beams (5, 7) along respective trajectories between input and output ports disposed in an array (3) using a reconfigurable Liquid crystal on silicon (LCOS) spatial light modulator device (17). The calibration system (25) includes a monitor (27) for projecting an optical monitor beam (29) through at least a portion of the switch (1) onto the LCOS (17) and detecting the monitor beam (29) reflected from the LCOS (17). In response, system (25) provides a calibration signal (33) to an active correction unit (35) for applying a correction to one or more of the trajectories while maintaining a constant switching state in the LCOS (17).

Abstract: Various embodiments include techniques for managing cache memory in a computing system. The computing system includes a sectored cache memory that provides a mechanism for software applications to directly invalidate data items stored in the cache memory on a sector-by-sector basis, where a sector is smaller than a cache line. When all sectors in a cache line have been invalidated, the cache line is implicitly invalidated, freeing the cache line to be reallocated for other purposes. In cases where the data items to be invalidated can be aligned to sector boundaries, the disclosed techniques effectively use status indicators in the cache tag memory to track which sectors, and corresponding data items, have been invalidated by the software application. Thus, the disclosed techniques thereby enable a low-overhead solution for invalidating individual data items that are smaller than a cache line without additional tracking data structures or consuming additional memory transfer bandwidth.

Abstract: An electrical box assembly is provided that includes an electrical box and a bracket connected to the electrical box with the bracket being configured to mount the electrical box to a stud, a brace assembly, in a gang application, or, when the electrical box is a first electrical box and the bracket is a first bracket that is mounted to a first side of the stud, a second bracket connected to a second electrical box can be mounted to a second side of the stud at the same time that the first bracket is mounted to the first side of the stud so that at least a portion of the first bracket is at the same height of at least a portion of the second bracket on the stud. A flat blank for a brace is additionally provided that includes a middle portion connected between a first strip and a second strip, a first cutout being formed between the first strip and the middle portion, and a second cutout being between the second strip and the middle portion.

Abstract: This invention relates to polynucleotides comprising optimized SLC13A5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a SLC13A5 gene or aberrant activity of a SLC13A5 gene product in the subject, such as citrate transporter disorder.

Abstract: The present invention relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics.

Abstract: Disclosed are embodiments that communicate label information for documents between two enterprise computer systems. The two computer systems operate asynchronous from each other, and have limited available resources for use in buffering information passing between them. To that end, traditional API architectures that utilize method calls and return parameters do not operate well in this environment, as a first computer systems resources can become exhausted if a second computer system is able to generate data faster than the first computer system can consume it. The problem is exacerbated if an error is experienced when processing the consumed data, especially if there are no resources available to store the data until the error can be cleared. To solve this problem, the disclosed embodiments provide an ability for a consumer to request that data previously delivered to it be delivered again by the producer, in some embodiments, after a specified time delay.

Abstract: A system or method for drilling includes autonomously controlling a rotary or percussive drilling process as it transitions through multiple materials with very different dynamics. The method determines a drilling medium based on real-time measurements and comparison to prior drilling data, and identifies the material type, drilling region, and approximately optimal setpoint based on data from at least one operating condition. The controller uses these setpoints initially to execute an optimal search to maximize performance by minimizing mechanical specific energy. Near-bit depth-of-cut estimations are performed using a machine learning prediction deployed in an embedded processor to provide high-speed ROP estimates. The sensing capability is coupled with a near-bit clutching mechanism to support drilling dysfunction mitigation.

Abstract: A method for training a learning system to identify components of time-based data streams includes processing, by a machine vision component in communication with a learning system, a video file to detect at least one object in the video file. The method includes generating by the machine vision component an output including data relating to the at least one object and the video file. The method includes analyzing, by a learning system, the output. The method includes identifying, by the learning system, an unidentified object in the processed video file.

Abstract: The invention relates to vise pivotal jaws for holding irregular shaped objects and that are modular to work on various sized prior art vises. Also relates to pivotal jaws having aid to return back to a neutral center position. The design allows ease of disassembly for cleaning and reassembly.

Abstract: A system for securely depositing an item includes: a deposit box with a door configured to provide selective access to an interior space in the deposit box; a lock mechanism configured to attach to the deposit box to selectively block the door from opening; a first proximity sensor operatively connected to the lock mechanism to operate the lock mechanism to block the door or allow the door to open; a second proximity sensor configured to be attached to at least one of: a delivery person and a piece of delivery equipment; a third proximity sensor; and a first transmitter operatively connected to the lock mechanism and configured to transmit a signal indicative of operating information regarding the lock mechanism.

Abstract: Methods and apparatus are provided for optical coherence metrology or tomography across an extended area of an eye with improved registration. At least two optical coherence tomograms are acquired, with each tomogram containing data from regions of an anterior surface of the eye that are at least partially overlapping, and data from one or more deeper structures such as the retina or the anterior or posterior lens surfaces. The tomograms are then processed to register the data from the overlapping portions of the anterior surface regions, thereby registering the data from the deeper structures. In certain embodiments the reference arm of the apparatus comprises a compound reflector having at least two axially separated reflective surfaces for applying differential delays to different portions of the reference beam. The depth of field of the apparatus is thereby extended to enable measurement of eye length.

Abstract: A walking aid accessory that is an aesthetic glider for a walker and a method of manufacturing.

Abstract: Apparatus and methods are presented for enhancing the acquisition speed or performance of Fourier domain optical coherence tomography. In preferred embodiments a plurality of wavelength combs containing interleaved selections of wavelengths from a multi-wavelength optical source are generated and projected onto a sample. In certain embodiments the wavelength combs are projected simultaneously onto a plurality of regions of the sample, while in other embodiments the wavelength combs are projected sequentially onto the sample. Light in the wavelength combs reflected or scattered from the sample is detected in a single frame of a sensor array, and the detected light processed to obtain a tomographic profile of the sample. In preferred embodiments the wavelength comb generator comprises a wavelength interleaver in the form of a retro-reflective prism array for imparting different displacements to different selections of wavelengths from the optical source.