Abstract: A method includes: determining that an agent-assisted service session should be initiated between a user and a human agent at some point after the user has initiated a user session, wherein the user session produces user session data; generating one or more temporary agent access numbers through which a communication channel may be established between the user and the human agent for the agent-initiated session; communicating a selected one or more of the temporary agent access numbers to the user in response to the determination that an agent-assisted service session should be initiated; establishing a communication channel for the agent-assisted session between the user and the human agent via a particular agent access number among the selected one or more temporary agent access numbers; associating the user session data with the agent-assisted session; and communicating the user session data to the human agent in conjunction with the agent-assisted session.

Abstract: The present invention provides a compound of Formula III: wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof.

Abstract: An active grille shutter system for use in a moving vehicle is provided herein and includes at least one vane angularly displaceable between an open position and a closed position, a motor having a hold current applied thereto for maintaining the at least one vane in a vane position, and a controller for adjusting the amount of hold current being applied to the motor based on vehicle speed.

Abstract: Described herein is a diffraction grating (1) for use in an optical system. The diffraction grating includes a substrate (2) and an array of elongate diffracting elements (3) arranged in a grating profile across the substrate. The grating profile imparts a predefined phase change to optical beams to at least partially correct the beams for optical aberrations present in the optical system.

Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.

Abstract: A corrosion resistant electrical system for communicating between a power source and multiple electric devices on a truck box or trailer. A hard plastic junction block with a male connector for power input communicates internally with two or more female connectors for power output, allowing multiple electric motors or other devices to receive electricity from a single power cable. The assembly includes cables with female or male connectors at the ends, the connectors having corresponding projecting portions and passageways, and U-shaped flanges and spaces, that fit together. The space between the projecting portions and the passageways are sealed by a resilient gasket around the projecting portion, and the U-shaped flanges and projecting portions contain aligned apertures to receive a lock pin to secure the mated connectors together.

Abstract: Described herein is a laser (1) having a cavity for supporting oscillation of an electromagnetic signal to provide lasing action. A gain element (5) provides a source of stimulated emission for amplifying the oscillating signal. The laser also includes a wavelength selective element (7), which includes a reflecting element and a polarization modifying element. The reflecting element selectively defines a predetermined wavelength and the polarization modifying element selectively modifies the polarization of the signal component at the predetermined wavelength so as to provide high selectivity. The wavelength selective element (7) rotates the signal polarization at the predetermined wavelength into an orthogonal state. A polarization filter (9) filters out the signal components having wavelengths not corresponding to the predetermined wavelength and a polarization rotation element (11) again rotates the polarization of the signal into an orthogonal state.

Abstract: A device for filtering air comprising a base, a fan functionally attached to the base, an air filter releasably attached to the base, and a substantially air impermeable outer sleeve is provided.

Abstract: A method for filtering air of about 1 to about 10 microns particles at a greater than 40% filtering efficiency is provided. The method includes providing an air filtering device comprising a base, a fan functionally attached to the base, an air filter releasably attached to the base, and a substantially air impermeable outer sleeve; and activating the device for at least about 20 minutes.

Abstract: A device for filtering air comprising a base, a fan functionally attached to the base, an air filter releasably attached to the base, and a substantially air impermeable outer sleeve is provided.

Abstract: A collapsible device for filtering air comprising a base, a fan functionally attached to the base, an air filter releasably attached to the base, and a substantially air impermeable outer sleeve is provided.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.

Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.

Abstract: A removable training aid for a human powered vehicle of the kind in which a pair of opposed cranks are provided which rotate relative to a common axis, the aid providing an audible or tactile indication in use that a rider is rotating the pedals by applying an incorrect pedalling technique, the removable training aid comprising an intermediary body, attachment means for attaching the body to at least one of the cranks and a pedal secured to the intermediary body, the removable training aid being arranged so that in use the pedal is free to rotate around an axis of rotation that is parallel to the common axis, the intermediary part permitting movement of the axis of rotation of the pedal relative to the crank through at least one degree of freedom in the event that a force is applied to the pedal along a path that is not perpendicular to an imaginary line that connects the axis of rotation of the crank with the threaded bore in the crank.

Abstract: Apparatus and methods for performing wavefront-based and profile-based measurements of an aspheric surface are disclosed. The apparatus includes an interferometric wavefront measurement system that collects wavefront-based measurement data of the aspheric surface. The apparatus also includes a profile measurement system that performs at least one non-contact profile-based measurement of the aspheric surface to collect profile-based measurement data of the aspheric surface. The measurements are performed without removing the aspheric element from a rotatable base. The two measurements are then used to form a combined measurement of the aspheric surface.

Abstract: Described herein are systems and methods of enhancing channel bandwidth in an optical system having a number of wavelength selective switching (WSS) devices. The method includes the steps of passing the optical signals through the WSS devices by: (i) spatially dispersing the wavelength channels of the optical signals; (ii) projecting the spatially dispersed channels onto corresponding predetermined regions of an optical manipulation matrix including a plurality of individually addressable manipulating elements; (iii) determining a modification function that specifies a state for each manipulating element within the predetermined region; and (iv) driving the elements of the corresponding regions at states specified by the function to selectively modify the channel band shape such that the received channel's bandwidth is substantially enhanced, and to spatially direct the wavelength channels to predetermined output ports of the WSS devices.

Abstract: A winder for winding a web to produce a rolled product is provided. The winder includes a web transport apparatus that is used for conveying the web. Also included in one exemplary embodiment is a plurality of independent winding modules. The winding modules are independently positioned to independently engage the web as the web is conveyed by the web transport apparatus. The winding modules may be configured to wind the web to form a rolled product by center winding, surface winding, and combinations of center and surface winding. The winding modules are structurally and operationally independent of one another where if one module is disabled, another may still operate to produce the rolled product without shutting down the winder.

Abstract: Described herein is a tunable optical filter (1). The filter includes a phase manipulation layer in the form of a liquid crystal material (3) and a diffractive layer in the form of a diffraction grating (5) sandwiched between an upper glass layer (7) and lower silicon layer (9). Grating (5) includes a grating structure (11) etched therein for angularly diffracting an input optical signal into a plurality of constituent wavelength components according to wavelength. Material (3) includes a two-dimensional array of independently addressable pixels (13), each pixel configured for receiving a drive signal and, in response to the drive signal, selectively modifying the phase of the wavelength components incident onto each pixel to directionally steer the components along respective angularly separated paths. By suitable steering of the wavelength components, at least one wavelength component is coupled along a predetermined collection path to an optical system such as a laser cavity.

Abstract: Automatic organ localization is described. In an example, an organ in a medical image is localized using one or more trained regression trees. Each image element of the medical image is applied to the trained regression trees to compute probability distributions that relate to a distance from each image element to the organ. At least a subset of the probability distributions are selected and aggregated to calculate a localization estimate for the organ. In another example, the regression trees are trained using training images having a predefined organ location. At each node of the tree, test parameters are generated that determine which subsequent node each training image element is passed to. This is repeated until each image element reaches a leaf node of the tree. A probability distribution is generated and stored at each leaf node, based on the distance from the leaf node's image elements to the organ.