Abstract: A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, R4, R5, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.

Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.

Abstract: Methods of benchmarking the problem solution space of a trial scenario for a combinatorial solver, as well as the characteristic performance of a combinatorial solver operating upon the trial scenario. Given a set of predetermined trial scenario data, the generalized method includes the steps of: (a) obtaining a random sequence; (b) reordering the predetermined trial scenario data into a randomized input form according to the random sequence; (c) inputting the randomized input form into a combinatorial solver; (d) solving the randomized input form with the combinatorial solver to produce a solution; (e) evaluating the solution to measure the value of a criterion of solution quality; and (f) recording the measured value of the criterion of solution quality in a data storage structure. The steps are repeated for a predetermined number of trials, whereupon the statistical distribution of the measured values is analyzed in order to determine at least one parameter of a statistical distribution function.

Abstract: A powertrain control system is disclosed. The powertrain control system may have a power source and a CVT coupled to an output of the power source. The powertrain control system may further have a controller in communication with the power source and the CVT. The controller may have a map with a plurality of speed modes, and, for at least one of the plurality of speed modes, the controller may be configured to vary an actual power source speed based on at least one of a CVT output speed or a ground speed.

Abstract: Coreless tissue rolls can be produced without having to use an adhesive to form a hollow center. Instead, moisture can be used to promote light hydrogen bonding between the layers of the tissue web that line the hollow center. The hydrogen bonding provides sufficient structure to maintain the shape of the hollow center without rendering the tissue web surrounding the passageway unusable. Passageways can also be formed in accordance with the present disclosure that are substantially circular so that the rolls will easily spin on a spindle. In an alternative embodiment, moisture is not used in constructing the wound tissue roll.

Abstract: The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.

Abstract: A stacked laminate component for a turbine engine that may be used as a replacement for one or more metal components is provided. The stacked laminate component can have a body formed by a process of stacking and laminating layers to define a radially inner surface along the hot gas path. The layers can be substantially orthogonal to the radially inner surface. The layers can be at least a first layer of a first material and a second layer of a second material. At least the first material is a ceramic matrix composite. The second material can have a higher thermal conductivity or a higher creep strength than the first material.

Abstract: A method of detecting a risk of a pregnant female mammal developing pre-eclampsia or a complication linked thereto, or of a fetus of the pregnant female mammal developing a fetal or neonatal deficiency linked to maternal pre-eclampsia, comprises detecting the level of a VEGFxxxb in a sample from the pregnant female mammal at less than about 24 weeks of gestation and comparing the detected level with a reference level. A reduced level in the sample from the pregnant female mammal is indicative of a risk of the pregnant female mammal developing pre-eclampsia or a complication linked thereto or of the fetus developing the fetal or neonatal deficiency linked to maternal pre-eclampsia.

Abstract: One embodiment of the present invention sets forth a technique for processing load instructions for parallel threads of a thread group when a sub-set of the parallel threads request the same memory address. The load/store unit determines if the memory addresses for each sub-set of parallel threads match based on one or more uniform patterns. When a match is achieved for at least one of the uniform patterns, the load/store unit transmits a read request to retrieve data for the sub-set of parallel threads. The number of read requests transmitted is reduced compared with performing a separate read request for each thread in the sub-set. A variety of uniform patterns may be defined based on common access patterns present in program instructions. A variety of uniform patterns may also be defined based on interconnect constraints between the load/store unit and the memory when a full crossbar interconnect is not available.

Abstract: A method of analyzing an input signal, the method including the steps of: (a) dividing a first input signal into first and second orthogonal signal polarization components; (b) dividing a second input signal into orthogonal first and second orthogonal local polarization components; (c) mixing the first orthogonal signal component with the second orthogonal local polarization component to provide a first mixed signal; (d) mixing the second orthogonal signal component with the first orthogonal local polarization component to provide a second mixed signal; (e) analyzing the first and second mixed signal to determine the polarization or phase information in the input signal.

Abstract: Approaches for assessing hemodynamic characteristics for an organ of interest are related. In one implementation, a fluid dynamics model may be provided with data derived from an anatomic imaging modality and blood flow information derived by ultrasound to derive the desired hemodynamic characteristics. In one such implementation, a fractional flow reserve is estimated.

Abstract: Systems and methods for multiple computer dataloading using a standard dataloader are provided. In one embodiment, a method for simultaneously uploading duplicate data to a plurality of computers comprises: performing a handshake message exchange with a dataloader to determine a MAC address for a target node; conducting a data transfer between the dataloader and the target node by forwarding a file transfer protocol message having the MAC address for the target node from the dataloader to the target node; forwarding the file transfer protocol message to at least one node other than the target node, wherein the at least one node and the target node both consume the file transfer protocol message; and selectively suppressing one or more response messages generated by the at least one node from reaching the dataloader.

Abstract: A system for acquiring and analyzing fault conditions for at least one coil of Magnetic Resonance Imaging (MRI) system. Each of the at least one coils is electrically connected through a transmit/receive (T/R) bias circuit to an interface. The system has a central processing unit with a processor configured to execute programmable instructions which when executed by the processor cause the processor to conduct circuit tests at predetermined intervals for the at least one coil, acquire data for the at least one coil to construct a data log with a plurality of input events, and algorithmically filter and analyze the plurality of input events to create an output configured to predict a failure event of the at least one coil. A method for analyzing and acquiring fault conditions is also provided.

Abstract: One embodiment of the present disclosure sets forth an optimized way to execute pre-scheduled replay operations for divergent operations in a parallel processing subsystem. Specifically, a streaming multiprocessor (SM) includes a multi-stage pipeline configured to insert pre-scheduled replay operations into a multi-stage pipeline. A pre-scheduled replay unit detects whether the operation associated with the current instruction is accessing a common resource. If the threads are accessing data which are distributed across multiple cache lines, then the pre-scheduled replay unit inserts pre-scheduled replay operations behind the current instruction. The multi-stage pipeline executes the instruction and the associated pre-scheduled replay operations sequentially. If additional threads remain unserviced after execution of the instruction and the pre-scheduled replay operations, then additional replay operations are inserted via the replay loop, until all threads are serviced.

Abstract: Streaming media is received from a source system. A current overall resource usage of a resource of the device (such as a CPU or memory of the device) is obtained. A check is made as to whether the current overall resource usage exceeds a resource threshold value. If the current overall resource usage exceeds the resource threshold value, then an indication is provided to the source system to reduce a quality level of the streaming media. The streaming media is received from the source system at the reduced quality level until there is sufficient resource capacity at the device to increase the quality level.

Abstract: A worksurface assembly includes a worksurface member having an upper surface, a bottom surface, a forward edge, a rearward edge, and an aperture that opens both upwardly and forwardly from the worksurface member, and a storage member including a pair of sidewalls, a rear wall and a bottom wall that cooperate to form an interior storage area having a height to width ratio of greater than or equal to about 1:1 at at least one position along a length of the storage member, wherein the storage member has a forwardly facing opening and an upwardly facing opening, and wherein the storage member is readily detachably secured to the worksurface member such that the interior storage of the storage member is accessible through the aperture of the worksurface member and such that access to the interior space is uninterrupted between the forwardly facing opening and the upwardly facing opening of the storage member.

Abstract: In one embodiment, a network control module permits any or all of power signals, traffic signals and controller command signals to be carried on as few as one wire or cable to a first port of the network control module. In another aspect, a “peripheral array” includes a network control module (in any one of a number of different possible embodiments), with one or more peripheral devices, such as antennas, attached to or coupled with the network control module outputs. In one embodiment, RFID “smart shelving” may be fabricated in sections, with several (for example, 4, 8 or 16) antennas in each section, and as few as one cable coupling adjacent sections. Additional embodiments are described and claimed.

Abstract: In a graphics processing pipeline, a processing unit establishes a bounding box around a polygon in order to identify sample points that are covered by the polygon. For a given sample point included within the bounding box, the processing unit constructs a set of lines that intersect at the sample point, where each line in the set of lines is parallel to at least one side of the polygon. When all vertices of the polygon reside on one side of at least one line in the set of lines, the processing unit may reduce the size of the bounding box to exclude the sample point.

Abstract: The raised flooring apparatus and system may be used to construct a raised floor directly onto joists while accommodating commonly accepted building practices utilizing 16? and 24? center to center joist spacing.

Abstract: A method is provided including determining a first power level required from a diesel powered system. The first power level corresponds to a first proportion of a maximum power. The method also includes determining an emission output for a mission based on the first power level. The method further includes determining a second power level corresponding to a second proportion of the maximum power, wherein alternate use of the second power level and at least one of the first power level or a third power level results in a lower emission output for the mission, with the overall resulting power being proximate the minimum power required. The method also includes automatically controlling operation of the diesel powered system by using the second power level alternately with at least one of the first power level or the third power level.