Abstract: Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: A beverage dispensing apparatus which includes a tank, a liquid inlet and a fluid dispensing system which includes a dispensing fluid conduit having a helical portion at least substantially vertically oriented within the interior volume of the tank. The beverage dispensing apparatus also includes a fluid circulating system that includes at least one fluid circulation conduit having an inlet portion positioned proximate the bottom portion of the tank and at least one outlet. A fluid cycling device is also included in the beverage dispensing apparatus and is configured to move fluid from the bottom portion of the tank to the fluid circulation conduit. The at least one outlet is configured to produce a fluid flow tangential to the orientation of the dispensing fluid conduit configuration. Evaporator coils extend around a perimeter of the tank's exterior sidewall surface and are configured to chill the fluid within the tank.

Abstract: The present invention relates to a container for a consumable good, wherein the container has an inner coating layer including resveratrol, and process for preparing the container.

Abstract: An elbow assembly for a mask system includes an elbow including a slot and a port, an anti-asphyxia valve adapted to be received within the slot and including a flap portion adapted to selectively close the port depending on the presence of pressurized gas, and a support member to secure the anti-asphyxia valve to the elbow. The support member includes a slot that is adapted to interlock with a protrusion provided to the anti-asphyxia valve.

Abstract: Aspects extend to methods, systems, and computer program products redoing transaction log records in parallel. Different aspects of replaying log records are allocated to different threads, for example, read threads, analysis threads, logical operation redo threads, and page operation redo threads. The different threads can be distributed across different processor cores. Activities at read threads, analysis threads, logical operation redo threads, and page operation redo threads can be performed on an ongoing basis and in parallel with activities at other threads (including user tasks). In some aspects, pre-allocated memory blocks are used in a lock free manner to store log records prior to processing by a page operation redo thread.

Abstract: A mouth cushion (20) for a mask system includes a side wall (50), an undercushion (52) extending away from the side wall (50), and a membrane (54) provided to substantially surround the undercushion (52) and adapted to form a continuous seal around an exterior of a patient's mouth in use. The side wall (50) includes spaced-apart prong support structures (60) that provide annular recesses (62) adapted to support respective nasal prongs (30). Each prong support structure (60) includes an alignment indicator (70) to aid correct assembly of the respective nasal prong (30).

Abstract: A near-eye optical display system utilizes a compact display engine that couples image light from an imager to a waveguide-based display having diffractive optical elements (DOEs) that provide exit pupil expansion in two directions. The display engine comprises a pair of single axis MEMS (Micro Electro Mechanical System) scanners that are configured to reflect the image light through horizontal and vertical scan axes of the display system's field of view (FOV) using raster scanning. The MEMS scanners are arranged with their axes of rotation at substantially right angles to each other and operate with respective quarter wave retarder plates and a polarizing beam splitter (PBS) to couple the image light into an in-coupling DOE in the waveguide display without the need for additional optical elements such as lenses or relay systems.

Abstract: A multi-mode cavity filter, including at least one dielectric resonator body incorporating a piece of dielectric material having a shape to support first resonant mode and a second substantially degenerate resonant mode; excitation device(s) for at least one of: establishing an electromagnetic field external to, but immediately adjacent to, a face of the dielectric resonator body or for extracting energy from an electromagnetic field located external to, but immediately adjacent to, a face of the dielectric resonator body, a layer of conductive material in contact with and covering the dielectric resonator body on the face of the dielectric resonator body: at least one aperture in the layer of conductive material for inputting signals to the dielectric resonator body and/or outputting signals from the dielectric resonator body, wherein the excitation device is located, in at least two dimensions, at an electrical center of the face of the dielectric resonator body.

Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: In implementations of hologram focus accommodation, a focus accommodation system is implemented for variable focus of a generated image, such as a hologram, that is displayed for viewing on a waveguide display. The focus accommodation system includes switchable polarization retarders that rotate a polarization of light of the generated image, where the light passes through the switchable polarization retarders along an imaging path in which the generated image is viewable. The focus accommodation system also includes polarization sensitive gratings alternatingly interspersed with the switchable polarization retarders. Each of the polarization sensitive gratings are configurable to diffract the light in a first polarization state and transmit the light in a second polarization state. The variable focus is adjustable to a focal distance at which a user perceives viewing the generated image as displayed by the waveguide display.

Abstract: A process for preparing a container for a beverage, wherein the process includes applying a coating layer, which includes a food grade coating and an additive, such as monomeric resveratrol, to an inner layer of a container wall.

Abstract: The present invention relates to a container for a consumable good having an inner coating layer comprising an antioxidant other than resveratrol, and a process for preparing the container.

Abstract: Examples are disclosed that relate to a near-eye display device including a holographic display system. The holographic display system includes a light source configured to emit light that is converging or diverging, a waveguide configured to be positioned in a field of view of a user's eye, and a digital dynamic hologram configured to receive the light, and project the light into the waveguide such that the light propagates through the waveguide.

Abstract: Methods and apparatuses for control admission to network resources are provided. Probationary service flows with a reduced priority are provisionally allowed to use network resources. As the network demonstrates its continued stability by the addition of the new probationary flows, each probationary flow can be re-assigned its original priority thereby promoting the probationary flow to a non-probationary status.

Abstract: A near-eye optical display system utilizes a compact display engine that couples image light from an imager to a waveguide-based display having diffractive optical elements (DOEs) that provide exit pupil expansion in two directions. The display engine comprises a pair of single axis MEMS (Micro Electro Mechanical System) scanners that are configured to reflect the image light through horizontal and vertical scan axes of the display system's field of view (FOV) using raster scanning. The MEMS scanners are arranged with their axes of rotation at substantially right angles to each other and operate with respective quarter wave retarder plates and a polarizing beam splitter (PBS) to couple the image light into an in-coupling DOE in the waveguide display without the need for additional optical elements such as lenses or relay systems.

Abstract: An input-coupler of an optical waveguide includes one or more Bragg polarization gratings for coupling light corresponding to the image in two different directions into the optical waveguide. The input-coupler splits the FOV of the image coupled into the optical waveguide into first and second portions by diffracting a portion of the light corresponding to the image in a first direction toward a first intermediate component, and diffracting a portion of the light corresponding to the image in a second direction toward a second intermediate component. An output-coupler of the waveguide combines the light corresponding to the first and second portions of the FOV, and couples the light corresponding to the combined first and second portions of the FOV out of the optical waveguide so that the light corresponding to the image and the combined first and second portions of the FOV is output from the optical waveguide.

Abstract: The present technology provides a method and system for monetizing the usage of a certain “reserved service,” which comprises usage of certain reserved wireless operating modes, such as Ultra High Coverage Mode (UHCM), usage of one or more reserved Modulation and Coding Schemes (MCSs), or a combination thereof. In some embodiments the reserved MCSs may be employed solely when using the reserved operating mode. Similarly, the reserved operating mode may be defined at least in part by its usage of the reserved MCSs.

Abstract: A capacitive fluid sensor is provided having a substrate having upper and lower ends and conductive members supported by the substrate. The conductive members are provided between the upper and lower ends of the substrate. The conductive members include an upper end conductive member, a lower end conductive member, and at least one included conductive member which is positioned between the upper and lower end conductive members. Each conductive member is separated from every other one of the members, thereby providing that each member has distinct upper and lower ends and acts as an independent sensor. At least one pair of proximally positioned members are positioned relative to each other such that the distinct lower end of one of the pair of conductive members is positioned closer to the lower end of the substrate than is the distinct upper end of the other one of the pair of conductive members.