Abstract: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: A system and method for controlling an AC motor drive includes a control system programmed with an algorithm configured to optimize operation of the motor drive. Specifically, the control system is programmed to input an initial voltage-frequency command to the drive. The initial voltage-frequency command includes a voltage reference and a frequency reference corresponding to an operating point of an initial voltage/frequency (V/Hz) curve. The control system monitors a real-time output of the drive, modifies the voltage reference based on the real-time output of the drive, and transmits a modified voltage-frequency command to the drive. The modified voltage-frequency command corresponds to an operating point of a modified V/Hz curve defined by the modified voltage reference and the initial V/Hz curve.

Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein A1, A2, A3, L1, L2 and D are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the Compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: A method for installing a paver system includes positioning a first grid substrate adjacent to a second grid substrate, the first and second grid substrates form a paver support surface. At least the first grid substrate includes an integrated boundary ridge extending along the first paver support surface. The first grid substrate is interlocked with the second grid substrate with a first paver piece bridging the first and second grid substrates to form a paver linkage. Movement of at least the first paver piece is arrested beyond the integrated boundary ridge by directly or indirectly engaging at least the first paver piece against the integrated boundary ridge. In another example, movement of the first paver piece is arrested by anchoring at least the first paver piece on the first and second paver support surfaces through distribution of forces incident on at least the first paver piece through the paver linkage.

Abstract: A method and apparatus are provided for abbreviating the blind decoding process performed by a UE, such as an LTE UE, on control channel data such as PDCCH data of PRB pairs of a set of PRB pairs transmitted concurrently within a subframe. In some embodiments, only a prioritized portion of the PDCCH data is decoded, thereby expediting blind decoding. In some embodiments, a reduced number of encoding options for the PDCCH data is used, and blind decoding is expedited by considering only such options as possibilities. When blind decoding of the PDCCH data is completed before the end of the subframe, this may be used to identify and discard corresponding PDSCH data which is irrelevant to the UE. The prioritized portion may be adjusted as needed to include the CSS so as not to miss certain critical data.

Abstract: An inline view port is presented to a user in response to the user selecting an identifier in the code whereby the user is able to see relevant information related to the identifier in a spatially consistent location with the code that is being investigated. The user further has the ability to dive further into portions of the viewport document without having to leave the current editor, drive into additionally relevant portions of code through the viewport, and cascade the viewports such that multiple levels of depth of relationships can be viewed in the viewport.

Abstract: The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed. Examples of compounds of the invention include the compounds according to Formula Ia, or a pharmaceutically acceptable salt thereof, and the compounds of the examples.

Abstract: The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

Abstract: Creating and processing a natural language grammar set of data based on an input text string are disclosed. The method may include tagging the input text string, and examining, via a processor, the input text string for at least one first set of substitutions based on content of the input text string. The method may also include determining whether the input text string is a substring of a previously tagged input text string by comparing the input text string to a previously tagged input text string, such that the substring determination operation determines whether the input text string is wholly included in the previously tagged input text string.

Abstract: The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula III: wherein the variables are as defined herein.

Abstract: Aspects can be for ray tracing of 3-D scenes, and include dynamically controlling a population of rays being stored in a memory, to keep the population within a target, a memory footprint or other resource usage specification. An example includes controlling the population by examining indicia associated with rays returning from intersection testing, to be shaded, the indicia correlated with behavior of shaders to be run for those rays, such that population control selects, or reorders rays for shading, to prioritize shading of rays whose shaders are expected to produce fewer rays.

Abstract: The present invention provides substituted pyrido[2,3-b]pyrazines which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such substituted pyride[2,3-b]pyrazines are also encompassed.

Abstract: Adsorbent compositions useful in adsorption and separation processes are made using silicone-derived binding agents. The adsorbent compositions are made from crystallite aluminosilicate particles bound with silicone-derived binding agents, and optionally small amounts of a clay binder, to form agglomerated crystallite particles and are calcined to volatilize the organic components associated with the silicone-derived binding agents. The agglomerated crystallite particles have superior pore structures and superior crush strengths at low binder concentrations and exhibit enhanced N2 adsorption rates and capacities when used in air separation processes.

Abstract: A mouth cushion for a mask system includes a side wall, a membrane extending from the side wall and adapted to form a continuous seal around an exterior of a patient's mouth in use, and at least one support strut or rib provided to the side wall. The at least one support strut or rib is at least partially determinative of a deflection characteristic of the mouth cushion.

Abstract: A method and apparatus for motion estimation in a sequence of video images involves a) subdividing each field or frame of a sequence of video images into a plurality of blocks, b) assigning to each block in each video field or frame a respective set of candidate motion vectors, c) determining for each block in a current video field or frame, which of its respective candidate motion vectors produces a best match to a block in a previous video field or frame, d) forming a motion vector field for the current video field or frame using the thus determined best match vectors for each block, and e) forming a further motion vector field by storing a candidate motion vector derived from the best match vector at a block location offset by a distance derived from the candidate motion vector.

Abstract: The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: In one embodiment, an apparatus, includes: a mandrel; an expansion cylinder, comprising: opposite first and second ends; an inner circumferential surface extending between the ends and characterized by an inner diameter, the inner circumferential surface defining a hollow cavity; an outer circumferential surface extending between the ends and characterized by an outer diameter that is greater than the inner diameter; and a plurality of slots extending from the inner circumferential surface to the outer circumferential surface and latitudinally oriented between the ends; and one or more base plates configured to engage one of the ends of the expansion cylinder. In another embodiment, a method includes: arranging an expansion cylinder inside a test cylinder; arranging a mandrel inside the expansion cylinder; applying a force to the mandrel for exerting a radial force on the expansion cylinder; and detecting one or more indicia of structural failure of the test cylinder.

Abstract: The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula III: wherein the variables are as defined herein.