Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein A, B, W, X and Y are as defined herein.

Abstract: Disclosed herein is a removable leg rest for a wheelchair. The removable leg rest includes a base member configured to be mounted to a wheelchair frame having a wheelchair frame member. The removable leg rest also includes a leg support member pivotally coupled to the base member, and an actuator for pivoting the leg support member relative to the base member between a lowered position and a raised position. One or more mounting clips are used for attaching the base member to the wheelchair frame member. The mounting clips are configured to releasably engage a cross-sectional portion of the wheelchair frame member.

Abstract: A method and apparatus for decoding the LTE physical broadcast channel (PBCH). The transmissions are made by an evolved NodeB (eNB). At least one template symbol sequence representative of a potential transmission by the eNB over the PBCH is provided. A signal or signals transmitted over the PBCH by the eNB is received, the signal or signals indicative of a received symbol sequence. Correlation operations are performed for correlating the at least one template symbol sequence against the received symbol sequence. A representative symbol sequence, timing parameter, or both, is selected, based on the correlation operations. The representative symbol sequence is indicative of information transmitted by the eNB over the LTE PBCH. The timing parameter is indicative of timing of said information transmitted by the eNB.

Abstract: Exemplary embodiments involve real-time commenting in experience-sharing sessions. An exemplary method involves: (a) a server system facilitating an experience sharing session between a sharing device and one or more viewing devices, wherein the server system receives media in real-time from the sharing device and transmits the media to the one or more viewing devices in real-time, wherein the media comprises video; (b) during the experience sharing session, the server system receiving one or more comments from one or more of the viewing devices; (d) the server system filtering the received comments in real-time based on filter criteria; and (e) the server system initiating real-time delivery, to the sharing device, of one or more of the received comments that satisfy the filter criteria.

Abstract: A fire suppression and annunciation system using a flexible conduit and a wire rope is provided. The wire rope may be connected to a knob assembly at a universal pull station and to a release mechanism of the fire suppression system. An operator may pull a handle of the knob assembly at the universal pull station, thereby activating the release mechanism to release fire suppression agent. A flexible conduit may house the wire rope along at least a part of the connection from the universal pull station to the release mechanism. A material on the liner of the flexible conduit and/or on the wire rope may be used to reduce the coefficient of friction of wire rope in the flexible conduit. The fire suppression system may further include a pulley block system connected to the universal pull station. The pulley block system may comprise bearings, and may lower the force necessary to activate the release mechanism.

Abstract: The present disclosure describes an additive that may be used in the manufacture of thin-film polyamide composite membranes. Thin-film polyamide composite membranes are used in filtration processes, such as reverse osmosis and nanofiltration. The additive may be an amino-siloxane compound. The amino-siloxane compound includes repeated groups of silicon bonded to oxygen with at least one amine functional group. Optionally, the amino-siloxane compound may also include a hydrophilic group. The additive reacts with an aqueous phase and an organic phase to form a thin polyamide film on a porous substrate.

Abstract: A beverage dispensing apparatus which includes a tank, a liquid inlet and a fluid dispensing system which includes a dispensing fluid conduit having a helical portion at least substantially vertically oriented within the interior volume of the tank. The beverage dispensing apparatus also includes a fluid circulating system that includes at least one fluid circulation conduit having an inlet portion positioned proximate the bottom portion of the tank and at least one outlet. A fluid cycling device is also included in the beverage dispensing apparatus and is configured to move fluid from the bottom portion of the tank to the fluid circulation conduit. The at least one outlet is configured to produce a fluid flow tangential to the orientation of the dispensing fluid conduit configuration. Evaporator coils extend around a perimeter of the tank's exterior sidewall surface and are configured to chill the fluid within the tank.

Abstract: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.

Abstract: A method and apparatus for communicating system information in a wireless communication system is provided. The method comprises generating and sending by a base station, for example an eNB, a system information block (SIB) which includes at least one correlation enhancement bit. This SIB is received by the terminal, for example a MTC UE, and this SIB is subsequently correlated with a previously received SIB. Further, upon the correlation of the SIB and the previously received SIB, a determination is made whether the SIB has in fact changed. Upon determining if the SIB has changed, the terminal selects the correct SIB which is to be used for configuring communication with the base station.

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula IV: wherein the variables are as defined herein.

Abstract: The present invention relates to polypeptides directed against or specifically binding to CXC chemokine receptor 2 (“CXCR2”) and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

Abstract: A customizable multi-stage fluid treatment assembly typically includes a connector, a plurality of cartridges, and a cap. The plurality of cartridges have a treatment medium spaced within an interior volume of the individual cartridges, between the ends thereof. The ends of the plurality of cartridges are configured to receive a fluid, bring the fluid into operative contact with the treatment medium, and dispense the fluid from the opposing end of the cartridge. The connector is coupled with one end of the plurality of cartridges and has an inlet and an outlet for receiving and dispensing the fluid to and from an appliance. The cap is coupled with the other end of the plurality of cartridges, enclosing the fluid treatment assembly, which is configured to be received in a cavity of an appliance. The cartridges of the plurality of cartridges may be individually replaced with cartridges to meet customized needs.

Abstract: Thermoplastic polymers, for example fluoropolymers, are foamed by use of a solid formulation comprising thermoplastic polymer and an oxalate compound which includes a moiety selected from potassium, calcium, titanium, iron, cobalt, nickel, copper, zinc, zirconium and barium.

Abstract: The present invention provides a multi-mode cavity filter in which signals are coupled to or from a resonator body, using a coupling path with first and second portions arranged such that current flows in opposite directions and the couplings due to the magnetic fields generated partially cancel one another. In this way, the degree of coupling to any particular mode of the filter can be closely controlled by varying the length and/or orientation of the portions with respect to each other.

Abstract: A method of forming a semiconductor structure includes forming a first isolation region between fins of a first group of fins and between fins of a second group of fins. The first a second group of fins are formed in a bulk semiconductor substrate. A second isolation region is formed between the first group of fins and the second group of fins, the second isolation region extends through a portion of the first isolation region such that the first and second isolation regions are in direct contact and a height above the bulk semiconductor substrate of the second isolation region is greater than a height above the bulk semiconductor substrate of the first isolation region.

Abstract: A fluid treatment apparatus includes a base portion, a medium or media, and an elongated support portion. The base portion has a first end, a second end, and a side with an exterior surface. The first end has an inlet and outlet for receiving and dispensing a water flow, respectively. The medium or media is spaced within the base portion and receives fluid through the inlet, treats the fluid, and dispenses the fluid through the outlet. The elongated support portion extends from the second end of the base portion and has a sidewall. The sidewall has an exterior facing surface that is substantially aligned with the exterior surface of the side. The elongated support portion maintains a latch assembly location for engaging a filter head assembly and is configured to withstand torsional forces applied by the user for engagement and alignment with an elongated receiving cavity of an appliance.

Abstract: Thermoplastic polymers, for example fluoropolymers, are foamed by use of a solid formulation comprising thermoplastic polymer and manganese oxalate.

Abstract: Disclosed herein are methods and corresponding systems for facilitating a live registry event between a shopper and one or more remote viewers. In the live registry event, the shopper, registers for gifts that they would like to receive while sharing their registering experience with the viewers in real-time. When the user registers for an item, a server system allows the viewers to purchase the gift for the shopper.

Abstract: A disconnectable buoyant turret mooring system for an FPSO is vulnerable to damage from collisions between the buoy and the buoy turret cage during mating and de-mating operations. It is therefore desirable that the buoy separate quickly from the turret of the FPSO vessel during a disconnect operation. A buoy turret cage is provided with a certain degree of porosity that allows a flow of seawater from the outside of the receptor to the inner surface of the receptor. Introducing water in this way relieves the suction forces and allows for a quicker separation of the buoy from the turret of the FPSO vessel, minimizing the time during which an uncontrolled collision between the buoy and the FPSO vessel is most likely. Filling a portion of the turret above the mooring buoy with water prior to releasing the buoy also decreases the separation time.