Abstract: The present invention relates generally to the cosmetic treatment of aged skin. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating photo-aged and/or chronologically-aged skin.

Abstract: The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.

Abstract: The present invention relates to a novel crystalline form of ingenol mebutate, methods of preparation thereof, and to its use. More specifically, the invention relates to the conversion of amorphous ingenol mebutate (ingenol-3-angelate, PEP005) to a crystalline form, which was characterized by single crystal X-Ray crystallography (XRC), attenuated total reflectance Fourier transform infrared (FTIR-ATR) spectroscopy and Differential Scanning calorimetry (DSC).

Abstract: An escape ladder assembly (20) for mounting adjacent a window opening (4) in a building is provided, the window opening comprising a substantially horizontal window sill (8), the escape ladder assembly comprising a housing (22) for mounting in the wall adjacent the window opening, the housing having an opening in the window sill; a foldable ladder (32); at least one wall engaging fastening means (30) for connecting an end of the foldable ladder to the wall; wherein the foldable ladder is removable from within the housing through the opening in the window sill.

Abstract: An apparatus comprises a first transducer support configured to receive a first transducer in a first opening. A face of the first face of the transducer is located in a first plane. The apparatus also comprises a second transducer support configured to receive a second transducer in a second opening. A face of the second transducer is located in a second plane substantially parallel to the first plane.

Abstract: A flowline electrical impedance generation apparatus for generating a local electrical impedance in a metallic tubing portion of a flowline may be used in place of insulation joints in various systems. The impedance generation apparatus is tuned or tuneable to achieve maximum impedance at chosen frequencies, i.e., frequencies which it is desired to block.

Abstract: Downhole electrical power generation apparatus and methods of using stored pressurized gas and/or ambient downhole pressure. One example comprises first and second fluid receiving chambers, a fluid communication path for allowing flow of fluid from the first chamber via the fluid communication path to the second chamber and a turbine generator disposed so that fluid flowing from the first chamber via the fluid communications path to the second chamber operates the turbine generator to generate electrical power.

Abstract: The present invention is an integrated control system for use with various home appliances, such as washing machine, dryers, refrigerators, dishwashers, and the like. In a first embodiment of the present invention, the integrated controls are incorporated into a polycarbonate clear door panel, and incorporate proximity switches and controls to provide control and operation of the applicance. Light emitting diodes (LEDs) are optionally incorporated into a door handle for the appliance in an area out of sight such that only the light produced by the LEDs is seen and illuminates a handle for opening the door of the appliance. Additionally, opaque glass technology may be incorporated into one or more surfaces of the appliance which enables an opaque panel to become transparent to view the content of the interior of the appliance, such as a refrigerator.

Abstract: A well installation including metallic structure having downhole metallic tubing for conveying product towards the surface, a sub surface safety valve disposed in the downhole metallic tubing for interrupting flow of product towards the surface when closed and allowing flow of product towards the surface when open. Also, valve control means are disposed downhole and arranged for detecting electrical signals in the downhole metallic tubing and for holding the valve open while receiving an electrical signal, and surface signaling means for applying an electrical signal to metallic structure of the well for transmission via the downhole metallic tubing towards the valve control means so as to hold the valve open. The system can be made more robust by ensuring that the control means will only hold the valve open while receiving a signal of given characteristics to help prevent stray currents erroneously holding the valve open.

Abstract: A method of making shape-adaptable and spectral-selective distributed optical radiation sources, in the wavelength range between UV and mid-infrared, for therapeutic treatment using passive host medium containing nanocrystals is disclosed. The spectral output of the distributed optical radiation source is controlled by the nanocrystal size distribution that determines the spectral output of fluorescence radiation originating from these nanocrystals from within the said host medium, which contains the said nanocrystals, under excitation by an external source. The size of nanocrystals, or the size distribution of nanocrystals, incorporated in the host medium is selected based on the radiation spectral output required for therapeutic requirements. The passive host medium, incorporating the said nanocrystals, is made of adaptable, geometrically configurable, material that conforms to any desired shape.

Abstract: An apparatus comprises a substrate and transducers disposed over the substrate, each of the transducers comprising a different resonance frequency. A transducer device comprises circuitry configured to transmit signals, or to receive signals, or both. The transducer device also comprises a transducer block comprising a plurality of piezoelectric ultrasonic transducers (PMUT), wherein each of the PMUTs; and an interconnect configured to provide signals from the transducer block to the circuitry and to provide signals from the circuitry to the transducer block.

Abstract: Intelligent resource state memory recall techniques, and associated apparatus and methods, are disclosed. States of one or more video switcher resources in a resource state memory may be recalled to the same or different resources, depending on resource availability at the time of memory recall. A memory recall need not affect an on air signal. The memory may be recalled to recreate a desired program output, as defined in the memory, on a preview output of the video switcher, which leaves a current program output of the video switcher undisturbed when the memory is recalled.

Abstract: A device comprises: a first acoustic transducer; a second acoustic transducer; one or more transducer drivers; one or more signal receivers; and a transducer configuration device for selectively configuring connections between: (1) at least one of the first and second acoustic transducers; and (2) the one or more transducer drivers and the one or more signal receivers, according to a selected operating mode for the device among a plurality of possible operating modes.

Abstract: Methods and systems are described for communicating with downhole locations and transmitting power to downhole locations. Use is made of a cable passing someway down into the well. This cable may be connected to a downhole sensor and may be used primarily for communicating with that sensor, but also used in the current techniques described herein. Electrical connection is achieved between the cable and the metallic structure of the well to allow signals to be transferred between the communications tool and the surface via the cable.

Abstract: A transducer device includes an acoustic transducer, a parameter extractor and a feedback circuit. The parameter extractor is configured to extract an operating parameter from the acoustic transducer. The feedback circuit is configured to generate a correction signal based on a difference between the extracted operating parameter and a corresponding reference parameter. The correction signal is applied to adjust the operating parameter of the acoustic transducer.

Abstract: The invention relates to a thin film coated array and the process of fabricating and using the array including methods of etching, depositing a thin film coating, preparing and using the thin film coated array.

Abstract: An aircraft (10) or other conductive body having an electrical conductor which is capable of storing electrical charge, the aircraft comprising: connection means (20, 22, 24) for connecting said conductor with at least one other aircraft (10) having an electrical conductor capable of storing electrical charge so that stored charge can be transferred to and/or received from said at least one other aircraft; and control means (32, 34) for controlling transmission of charge so as to convey information to said at least one other aircraft and/or information extraction means (32, 34) for extracting information from the transmission of charge received from said at least one other aircraft.

Abstract: The present invention relates generally to the treatment of cutaneous lesions containing cells infected by a virus, as well as compositions for the treatment of such lesions. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating lesions caused by infection with a papilloma virus, such as a mammalian papilloma virus, in particular a Human Papilloma Virus.

Abstract: A piezoelectric transducer device includes a receive signal path, a transistor and a piezoelectric transducer connected to a first terminal of the transistor. The device also includes a switch connected to a second terminal of the transistor, wherein the switch is adapted to selectively connect the second terminal of the transistor to a transmit signal or to a bias voltage; an output connected to a third terminal of the transistor, and adapted to receive a signal from the transducer when the switch is connected to the bias voltage, wherein the switch is not in the receive signal.

Abstract: A cover and method for covering openings an particularly openings initially intended to cover door knob openings and lock set openings of a modified door which are required to be covered for aesthetic and security reasons. In one embodiment, the cover for a door knob hole is an integral stack of disks wherein the largest outermost disk covers the opening when centered by the second disk that fits snugly inside the opening. A bridge fits inside the lock-set cavity to which a cover over the lock cavity is bolted.