Abstract: A method of aligning a first component and a second component with elastic averaging includes offsetting a first part and a second part of the first component and creating a shut-off slot between the first part and the second part of the first component by offsetting the first part and the second part. The shut-off slot has a slot vector that is not parallel to a main die vector.

Abstract: Embodiments of the invention provide a surgical snare structure in which the material used for the snare and the deployment mechanism of the snare are configured to improve the cutting efficacy of the snare. In particular, the surgical snare structure of the invention may omit the kink or nib present in the loop of known surgical snares and/or may provide a reaction surface against which the cutting action of the snare is effective. The surgical snare of the invention may be a cold, i.e. mechanical-only effect, snare, or may be used in conjunction with radiofrequency (RF) and/or microwave energy to enhance a cutting or coagulation effect.

Abstract: An attraction system includes a first level, a second level positioned vertically above or below the first level, and one or more controllers configured to present a game environment to one or more riders in a ride vehicle as the ride vehicle travels along a path on the first level. The attraction system also includes a lift configured to move the ride vehicle vertically from the first level to the second level based at least in part on a performance of the one or more riders in the game environment.

Abstract: An electrosurgical instrument for applying to biological tissue RF electromagnetic energy and/or microwave frequency EM energy, wherein the instrument tip has a protective hull with a smoothly contoured convex undersurface facing away from a planar body, and wherein the planar body has a tapering distal edge, and wherein an underside of the planar body extends beyond the protective hull at the tapering distal edge. Also disclosed herein is an interface joint for integrating into a single cable assembly all of (i) a fluid feed, (ii) a needle movement mechanism, and (iii) an energy feed (e.g. a coaxial cable), and a torque transfer device for permitting controlled rotation of the cable assembly within the instrument channel of an endoscope. The interface joint and torque transfer device may be integrated as a single component.

Abstract: An attraction system includes a first level, a second level positioned vertically above or below the first level, and one or more controllers configured to present a game environment to one or more riders in a ride vehicle as the ride vehicle travels along a path on the first level. The attraction system also includes a lift configured to move the ride vehicle vertically from the first level to the second level based at least in part on a performance of the one or more riders in the game environment.

Abstract: A method of aligning a first component and a second component with elastic averaging includes offsetting a first part and a second part of the first component and creating a shut-off slot between the first part and the second part of the first component by offsetting the first part and the second part. The shut-off slot has a slot vector that is not parallel to a main die vector.

Abstract: A ride control system includes a central controller configured to synchronize movements of separate groups of ride vehicles along a path. Each of the separate groups of ride vehicles includes multiple individual ride vehicles unconnected to one another and forming a virtual train. Each virtual train is assigned one or more schedules having multiple expected positions along the path and multiple expected timestamps. Each of the expected timestamps of the multiple expected timestamps are associated with respective expected positions of the multiple expected positions. The ride control system also includes multiple vehicle controllers. Each vehicle controller of the multiple vehicle controllers is communicatively coupled to a respective individual ride vehicle of the multiple individual ride vehicles. Each vehicle controller is configured to control a speed of the respective individual ride vehicle along the path based at least on the one or more schedules.

Abstract: The present invention generally relates to the field of data encryption processes for crypto-currency or other digital asset transactions between a principal and beneficiary utilizing a custodian. Cryptographic protocols protect the asset from the custodian. It can also protect the asset from the principal. It can also protect the asset against the beneficiary until such time as the beneficiary can prove certain logical conditions that give it exclusive control over the digital asset.

Abstract: The present invention generally relates to the field of data encryption processes for crypto-currency or other digital asset transactions between a principal and beneficiary utilizing a custodian. Cryptographic protocols protect the asset from the custodian. It can also protect the asset from the principal. It can also protect the asset against the beneficiary until such time as the beneficiary can prove certain logical conditions that give it exclusive control over the digital asset.

Abstract: The invention provides a molecule that modulates an activity of a Src family kinase for use in preventing or treating a metastatic cancer a subject. Preferably, the molecule comprises or consists of the structure: Bj-[(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys]m-Rp, or Bj-[lys-ile-arg-ala-his-pro-his-xr-(pro)n]m-Rp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xr-(pro)n] is the retro-inverso peptide of [(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys].

Abstract: An electrosurgical resection instrument for applying to biological tissue radiofrequency electromagnetic energy has a protective hull comprising a shaped piece of dielectric material mounted to cover an underside of an instrument tip of the instrument. The protective hull acts as a shield to protect tissue that may lie under the instrument tip from damage during treatment. The instrument may be particularly useful in procedures performed in a gastrointestinal tract, where bowel perforation concern, or in the pancreas, where damage to the portal vein or the pancreatic duct may occur when a tumor or other abnormality is being resected, dissected or removed.

Abstract: An electrosurgical resection instrument for applying to biological tissue radiofrequency electromagnetic energy has a protective hull comprising a shaped piece of dielectric material mounted to cover an underside of an instrument tip of the instrument. The protective hull acts as a shield to protect tissue that may lie under the instrument tip from damage during treatment. The instrument may be particularly useful in procedures performed in a gastrointestinal tract, where bowel perforation is a concern, or in the pancreas, where damage to the portal vein or the pancreatic duct may occur when a tumor or other abnormality is being resected, dissected or removed.

Abstract: A ride control system for controlling a plurality of vehicles on a path includes a path processor and a bi-directional voting circuit in circuit with the path processor. Each vehicle of the plurality of vehicles may include a vehicle processor supported by the at least one vehicle and shunt relays in circuit with the at least one vehicle processor. Each vehicle processor may be configured to close a respective shunt relay upon a predetermined condition of the vehicle whereby the bi-directional voting circuit is activated to notify all other vehicles.

Abstract: The invention includes an XRF analyzer with reduced x-ray attenuation between sample and target and between sample and detector. Attenuation can be reduced by removing atmospheric-air paths through which the x-rays must travel. Reduced x-ray attenuation can allow for easier detection of low-atomic-number elements. Cost saving can be achieved by reducing the number of x-ray windows.

Abstract: A narrow profile surgical ligation clip has two legs with clamping surfaces joined by a hinge near the proximal ends, allowing the clip to reversibly open and close. A locking mechanism is proximal to the hinge to bias or lock the clip closed, including first and second jaw structures spaced on opposite sides of a longitudinal axis of the clip thereby defining a locking space therebetween. In one embodiment, a wedge or buttress body moves by application of an external force applied to a proximal end of the clip towards the hinge to move into the locking space such that one or more outer surfaces or projections of portions of the body fit into or abut against complementary surfaces or other parts of the locking mechanism or clip assembly to bias or lock the clip in a closed position and provide additional closing force to the inner clamping surfaces.

Abstract: An applier for ligation clip is provided. The applier includes: an outer tube having mounting bosses; a pair of jaws pivotally connected to the mounting bosses, the jaws having actuating projections; a feed tube located in the outer tube and configured to move axially within the outer tube, the feed tube having actuating slots in which the actuating projections are located; a clip lock arm located in the outer tube and configured to move axially within the outer tube; and a clip advance arm located in the outer tube and configured to move axially within the outer tube, the clip advance arm having flexible pinchers at one end of the clip advance arm. A method of applying a ligation clip is also disclosed.

Abstract: The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynaecological condition in which an activity of AR and/or ER is a contributory factor in a subject.

Abstract: The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynecological condition in which an activity of AR and/or ER is a contributory factor in a subject.

Abstract: A ride control system includes a central controller configured to synchronize movements of separate groups of ride vehicles along a path. Each of the separate groups of ride vehicles includes multiple individual ride vehicles unconnected to one another and forming a virtual train. Each virtual train is assigned one or more schedules having multiple expected positions along the path and multiple expected timestamps. Each of the expected timestamps of the multiple expected timestamps are associated with respective expected positions of the multiple expected positions. The ride control system also includes multiple vehicle controllers. Each vehicle controller of the multiple vehicle controllers is communicatively coupled to a respective individual ride vehicle of the multiple individual ride vehicles. Each vehicle controller is configured to control a speed of the respective individual ride vehicle along the path based at least on the one or more schedules.

Abstract: Various techniques are described herein for generating and managing computing infrastructure instances within datacenters. Data identifying various computing infrastructure characteristics may be receive and analyzed in order to determine one or more computing infrastructure definitions to be instantiated within a datacenter. Specific datacenters may be determined for instantiating the computing infrastructure definitions, various provisioning and configuration management tools may be selected, and computing infrastructure instances comprising multiple interoperable services (e.g., web services) and other components may be provisioned, configured, tested, and maintained. In some examples, instance execution data may be received and analyzed via instance monitor components transmitted and deployed within computer infrastructure instances executing on datacenters.