Abstract: A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.

Abstract: Embodiments herein relate to flow control devices for cancer treatment systems and related methods. In an embodiment, a fluid flow control device for a cancer therapy system is included having a receiver housing, wherein the receiver housing can be configured to interface with a fluid delivery device. The fluid flow control device can also include a rotational plunger. The rotational plunger can include indicia, such as markings, on an end of the rotational plunger. The rotational plunger can be configured to engage with the receiver housing and rotation of the rotational plunger causes a plunger of the syringe to be depressed. Other embodiments are also included herein.

Abstract: A method and system for determining and displaying a turn to a heading entry for an aircraft has been developed. First, a preliminary heading selection and a preliminary turn direction are entered into an automated flight control system (AFCS) for an aircraft. The preliminary heading selection and the preliminary turn direction are displayed to a pilot of the aircraft. A subsequent heading selection is entered into the AFCS while the aircraft is engaged in turning to the preliminary heading selection in the preliminary turn direction. A shortest turn radius to the subsequent heading selection is determined. A determination is made if the shortest turn radius to the subsequent heading selection is the same direction and the preliminary turn direction and a notice is displayed to the pilot of the aircraft is the shortest turn radius to the subsequent heading selection is not the same direction and the preliminary turn direction.

Abstract: One or more datalink labels are displayed on a shared panel of a user interface. The datalink labels are generated in response to receiving a datalink message from at least one ground station. Upon receiving a selection of the datalink label, one or more sub-panels that include information or a representation of the datalink message are displayed on the user interface. In some embodiments, the sub-panel includes a button that, when selected, automatically generates a response message. Utilizing datalink labels in conjunction with the shared panel simplifies datalink messaging and enables messaging functions to be completed on the same screen regardless of which application (or function of an application) is currently displayed on the user interface.

Abstract: The present disclosure provides markers specific for pluripotent stem cells. In particular, the present disclosure relates to nucleic acid and polypeptide markers that are selectively expressed by pluripotent stem cells; and to methods for detecting the presence and/or absence of one or a plurality of pluripotent stem cells, by detecting such markers.

Abstract: A process for preparing a polymer-coated hard shell capsule can be performed. The hard shell capsule has a body and a cap. In the closed state the cap overlaps the body either in a pre-locked state or in a final-locked state. The hard shell capsule is provided in the pre-locked state and coated with a coating solution, suspension or dispersion that has at least one polymer; at least one glidant; at least one emulsifier; optionally at least one plasticizer; optionally at least one biologically active ingredient; and optionally at least one additive, different from the above. The process is used to obtain a coated, preferably only at the outer surface, hard shell capsule in the pre-locked state, wherein the coating solution, suspension or dispersion has a surface tension of at most 38 mN/m. The polymer-coated hard shell capsule obtained from the process is used for immediate, delayed or sustained release.

Abstract: To facilitate improved Controller-Pilot Data Link Communication (CPDLC) interfacing, report messages can be automatically armed and displayed in a threaded message format in the same message panel with other CPDLC messages between a vehicle and a ground system. Upon determining that a report is needed based on an uplink CPDLC message from the ground system, a report message label is displayed on the CPDLC message panel. Once the report is ready, it is automatically armed and the report message label indicates to the operator that the report message is ready to be sent. The operator can also select the report message label in the message panel to display the report message.

Abstract: Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.

Abstract: A process for preparing a polymer-coated hard shell capsule that has at least a functional coat and a top coat, suitable as container for pharmaceutical or nutraceutical biologically active ingredients can be performed. The hard shell capsule has a body and a cap, wherein in the closed state the cap overlaps the body either in a pre-locked state or in a final-locked state, wherein the hard shell capsule is provided in the pre-locked state and is coated with a first coating solution, suspension or dispersion that has at least one polymer; optionally at least one glidant; optionally at least one emulsifier; optionally at least one plasticizer; optionally at least one biologically active ingredient; and optionally at least one additive. The polymer-coated hard shell capsule obtained from the process according to the invention can be used for immediate, delayed or sustained release.

Abstract: A footwear article comprises: an outsole comprising: an outsole body comprising a first polyurethane polymeric material attached to one or more tread cleats comprising a nitrile butadiene rubber polymeric material; and a footwear upper affixed to the outsole, the footwear upper comprising a second polyurethane polymeric material. Footwear articles, including boots, overshoes, and/or work shoes, are effective to meet or exceed slip resistance in accordance with ASTM F3445-21. Methods of making the footwear articles are also described.

Abstract: A method of securing a filter element within a pressure vessel without a user breaching a plane of the pressure vessel is provided. The method includes attaching a filter locking nut to a removal/installation tool, wherein the removal/installation tool comprises an elongated body, inserting the filter locking nut into the pressure vessel, securing the filter locking nut to a threaded rod to secure a filter element in place, detaching the removal/installation tool from the filter locking nut, and removing the removal/installation tool from the pressure vessel. At least a portion of the elongated body of the removal/installation tool extends outside of the pressure vessel for the duration of the attaching, inserting, securing, detaching, and removing steps.

Abstract: A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.

Abstract: A transport and delivery system which may be used for injectable materials such as radioactive injectables. The system includes a base configured to hold a material transport device containing the injectable material, and a cover including a material delivery system and a material access device. The cover is configured to be mated over the base to result in alignment of the material access device with the material transport device to allow the material delivery system to deliver the injectable materials from within the material transport device to a patient. The cover may include a handle graspable within an adult hand to facilitate grasping/handling of the system. A priming cap may be provided to facilitate priming of the material delivery system and material access device to be substantially airless.

Abstract: In one example, a system includes HMI(s) and processor(s) communicatively coupled to the HMI(s) and a non-transitory computer-readable medium on which CPDLC interface instructions are stored. The CPDLC interface instructions are executable by the processor(s) and, when executed by the processor(s), cause the processor(s) to: generate a CPDLC GUI on the HMI(s), the CPDLC GUI configured to display icons representing a subnetwork, a Current Data Authority (CDA), and a Next Data Authority (NDA) for the CPDLC connection; in response to receiving a command via the CPDLC GUI to log on to a CPDLC session, establish the CPDLC connection with a ground station using the subnetwork and the CDA; generate an indicator or a button in a header of the CPDLC GUI that includes an indication of the subnetwork, the CDA, and the NDA for the CPDLC connection.

Abstract: A method for creating a Controller-Pilot Data Link Communications message (CPDLC message) is provided. The method includes receiving a request on a user interface of an avionics device to create the CPDLC message; displaying a menu with a plurality of types of CPDLC messages in a panel body on the user interface; receiving a selection of one of the plurality of types of CPDLC messages through the menu; populating the panel body with fields configured to gather data for the CPDLC message based on the selection; and creating the CPDLC message based on the data.

Abstract: A method for displaying CPDLC messages on a user interface is provided. The method includes receiving a CPDLC message for display on the user interface; determining whether the CPDLC message has a message reference number (MRN); if the CPDLC message does not have an MRN, displaying the CPDLC message in a first column in a panel body of the user interface if the CPDLC message is a downlink CPDLC message or in a second column in the panel body if the CPDLC message is an uplink CPDLC message; if the CPDLC message does have an MRN, identifying a prior CPDLC message having the MRN as a message identification number (MIN) for the prior CPDLC message; identifying whether the prior CPDLC message is in the first or the second column; and displaying the CPDLC message in an opposite column from the prior CPDLC message.

Abstract: To facilitate improved CPDLC interfacing, report messages can be automatically armed and displayed in a threaded message format in the same message panel with other CPDLC messages between a vehicle and a ground system. Upon determining that a report is needed based on an uplink CPDLC message from the ground system, a report message label is displayed on the CPDLC message panel. Once the report is ready, it is automatically armed and the report message label indicates to the operator that the report message is ready to be sent. The operator can also select the report message label in the message panel to display the report message.

Abstract: An enclosable and stackable container comprising a tray and lid is provided with structural elements to permit rapid covering and uncovering of the tray, efficient stacking of containers, and safe transportation. At least one catching mechanism may be engaged quickly to securely cover the tray and its food contents and disengaged quickly to uncover the tray and its food contents, improving food hygiene practices. Foldable flange flaps enhance stacking strength to permit safe transportation of stacked containers and their food contents.

Abstract: A footwear article comprises: an outsole comprising: an outsole body comprising a first polyurethane polymeric material attached to one or more tread cleats comprising a nitrile butadiene rubber polymeric material; and a footwear upper affixed to the outsole, the footwear upper comprising a second polyurethane polymeric material. Footwear articles, including boots, overshoes, and/or work shoes, are effective to meet or exceed slip resistance in accordance with ASTM F3445-21. Methods of making the footwear articles are also described.

Abstract: A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.