Abstract: An electronic system includes a first data retriever to communicate with a first database associated with an analytic tool, and a second data retriever to communicate with a second database associated with an electronic testing device; wherein the analytic tool is configured to store information regarding actual usage of a product in the first database; wherein the electronic testing device is configured to store product testing data for the product in the second database; wherein the first data retriever comprises a first communication interface to electronically receive the information; wherein the second data retriever comprises a second communication interface to electronically receive the product testing data; and wherein the electronic system further comprises a processing unit configured to compute a score indicating a quality of product testing for the product based on the information regarding the actual usage of the product and/or the product testing data.

Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Abstract: An article of manufacture comprising a waterproof zipper with at least one curve, where the zipper includes a first tape and a second tape, and interlocking elements attached to the first tape and the second tape, wherein the first tape and the second tape are curved, and wherein a curve of at least one of the tapes was caused by compaction of that tape. The zipper is coated on at least one side with a fluid impervious coating.

Abstract: A medical device system includes an elongate sheath defining a lumen extending within the elongate sheath. A coupler mechanism is slidingly disposed within the lumen, the coupler mechanism including a proximal coupler and a distal coupler. An elongate member is secured to and extends proximally from the proximal coupler. An implantable medical device (IMD) is secured to and extends distally from the distal coupler. The distal coupler remains secured to the proximal coupler while the coupler mechanism remains within the lumen, and the distal coupler releases from the proximal coupler, thereby releasing the IMD, when the coupler mechanism is exterior to the lumen.

Abstract: A zipper with at least one curve includes a first tape and a second tape, and interlocking elements attached to the first tape and the second tape, wherein the first tape and the second tape are curved, and wherein a curve of at least one of the tapes was caused by compaction of that tape, wherein compaction of the two tapes uses a compactor, and wherein the compactor comprises at least one drum, wherein the drum comprises a notch or groove to allow the zipper's interlocking elements to pass without pressure from the drum while the tapes on either side of the interlocking elements are being compacted.

Abstract: The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.

Abstract: Examples herein include methods, systems, and computer program products for utilizing neural networks in ultrasound systems. The methods include processor(s) of a computing device obtaining an image that depicts cells. The processor(s) applies one or more nuclei detection algorithms to detect nuclear aspects in the image. The processor(s) generates a nuclear segmentation map. The processor(s) utilizes the nuclear segmentation map to identify one or more regions of interest in the image. The processor(s) generates a classification result by automatically determining a cell type for each cell in a region of interest of the regions of interest.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for managing vehicle guidance using a GUI. One method may include: obtaining flight management system (FMS) data; updating an aircraft configuration state based on the FMS data; obtaining a current mode, active command, and a second command for a guidance panel based on the configuration state; and generating a guidance panel GUI based on the current mode, the active command, and the second command. Another method may include: obtaining vehicle data; updating a vehicle configuration state based on the vehicle data if the vehicle data has updated information; obtaining a current mode, active command, and a second command for a guidance panel of the vehicle based on the vehicle configuration state; generating a guidance panel GUI based on the current mode, the active command, and the second command; and displaying the guidance panel GUI on the guidance panel.

Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Abstract: Passive optical couplers having passive optical activity indicators and methods of operating the same are disclosed. An example passive optical coupler for passively coupling first and second optical fibers includes a housing including: a first port configured to receive an end of a first optical fiber, and a second port configured to receive an end of a second optical fiber; and a passive optical activity indicator positioned at least partially within the housing, wherein a first portion of the passive optical activity indicator is exposed through the housing, and wherein the passive optical activity indicator is configured to passively illuminate in response to (i) first light propagating in the first optical fiber when the end of the first optical fiber is received in the first port, and (ii) second light propagating in the second optical fiber when the end of the second optical fiber is received in the second port.

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: A sectioning system includes a chuck assembly configured to receive a tissue block, a cutting assembly configured to remove a tissue section from the tissue block, at least one sensor configured to sense data regarding dynamics of one or more components of at least one of the chuck assembly or the cutting assembly, and a control system. The control system is configured to receive data from the at least one sensor, determine whether the data from the at least one sensor shows normal behavior of the one or more components of at least one of the chuck assembly or the cutting assembly, and output a signal if it is determined the data from the at least one sensor does not show normal behavior of the one or more components.

Abstract: A zipper with at least one curve includes a first tape and a second tape, and interlocking elements attached to the first tape and the second tape, wherein the first tape and the second tape are curved, and wherein a curve of at least one of the tapes was caused by compaction of that tape.

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: The invention provides methods for treating cancer in a subject comprising administering an immunoconjugate of formula: Ab-[TA]r or a pharmaceutically acceptable salt thereof, wherein “Ab” is an antibody construct that has an antigen binding domain that binds human epidermal growth factor receptor type 2 (HER2) and “TA” is a therapeutic agent of formula: wherein n is from about 2 to about 25 and r is an average therapeutic agent to antibody ratio from 1 to 10, to a subject having cancer.

Abstract: The present invention is directed to combinations of menin inhibitors with one or more CYP3A4 inhibitors, pharmaceutical compositions thereof, and methods of treating cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A boot comprises: an outsole and a polymeric upper affixed to the outsole. The upper comprises an upper body and a gusset, which comprises a relaxed position and an expanded position, wherein the gusset moves from the relaxed position to the expanded position to accommodate a wearer's leg upon donning of the boot.

Abstract: Passive optical couplers having passive optical activity indicators and methods of operating the same are disclosed. An example passive optical coupler for passively coupling first and second optical fibers includes a housing including: a first port configured to receive an end of a first optical fiber, and a second port configured to receive an end of a second optical fiber; and a passive optical activity indicator positioned at least partially within the housing, wherein a first portion of the passive optical activity indicator is exposed through the housing, and wherein the passive optical activity indicator is configured to passively illuminate in response to (i) first light propagating in the first optical fiber when the end of the first optical fiber is received in the first port, and (ii) second light propagating in the second optical fiber when the end of the second optical fiber is received in the second port.