Abstract: An impact window assembly for use with an overhead door panel with an opening is disclosed. The impact window assembly includes a glazing sized to cover the opening and has an interior surface that overlap the overhead door panel about that opening. The assembly further includes a front frame having an outer edge at least slightly bigger than the opening in the overhead door panel and an inner edge smaller than the opening. The frame is vacuum-formed onto the glazing and the overhead door panel. The assembly may further include a first plurality of fasteners mechanically engaging the overhead door panel and glazing, a bead of structural sealing applied between the glazing and panel, and mounting tape between the glazing and front frame. Methods for assembling the impact window assembly are also disclosed.

Abstract: The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.

Abstract: An epoxy-free laser assembly includes at least one laser array and at least one optics assembly positioned within an optical path of at least one laser array. The laser array and the optics assembly are epoxy-free. In one example, the optics assembly has a beam shaping optic and a wavelength stabilization optic, wherein the wavelength stabilization optic is connected to beam shaping optic with at least one tab and solder. In another example, a plurality of optics assemblies is included within the laser assembly, whereby the laser array and all of the plurality of optics assemblies fit within a footprint of the heatsink. Methods of manufacturing the same are also provided.

Abstract: A method of securing a filter element within a pressure vessel without a user breaching a plane of the pressure vessel is provided. The method includes attaching a filter locking nut to a removal/installation tool, wherein the removal/installation tool comprises an elongated body, inserting the filter locking nut into the pressure vessel, securing the filter locking nut to a threaded rod to secure a filter element in place, detaching the removal/installation tool from the filter locking nut, and removing the removal/installation tool from the pressure vessel. At least a portion of the elongated body of the removal/installation tool extends outside of the pressure vessel for the duration of the attaching, inserting, securing, detaching, and removing steps.

Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Abstract: A boot comprises: an outsole and an upper affixed to the outsole, the upper comprising a polyvinyl chloride (PVC) upper body and a composite toe cap. The composite toe cap comprises a fiberglass reinforced polymer, and the composite toe cap comprises a tapered surface.

Abstract: An electronic system includes a first data retriever to communicate with a first database associated with an analytic tool, and a second data retriever to communicate with a second database associated with an electronic testing device; wherein the analytic tool is configured to store information regarding actual usage of a product in the first database; wherein the electronic testing device is configured to store product testing data for the product in the second database; wherein the first data retriever comprises a first communication interface to electronically receive the information; wherein the second data retriever comprises a second communication interface to electronically receive the product testing data; and wherein the electronic system further comprises a processing unit configured to compute a score indicating a quality of product testing for the product based on the information regarding the actual usage of the product and/or the product testing data.

Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.

Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Abstract: A system for protecting a surface of an electronic device includes a protective film and a liner. The protective film includes an adhesive-coated surface. The liner, which covers the adhesive-coated surface until the protective film is secured to the surface of an electronic device, covers a periphery of the adhesive-coated surface. The liner may also include one or more tabs for facilitating removal of the liner from the adhesive-coated surface of the protective film. Methods for using the system to apply a protective film to a surface, such as a surface of a display screen, of an electronic device are also disclosed.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for managing vehicle guidance using a GUI. One method may include: obtaining flight management system (FMS) data; updating an aircraft configuration state based on the FMS data; obtaining a current mode, active command, and a second command for a guidance panel based on the configuration state; and generating a guidance panel GUI based on the current mode, the active command, and the second command. Another method may include: obtaining vehicle data; updating a vehicle configuration state based on the vehicle data if the vehicle data has updated information; obtaining a current mode, active command, and a second command for a guidance panel of the vehicle based on the vehicle configuration state; generating a guidance panel GUI based on the current mode, the active command, and the second command; and displaying the guidance panel GUI on the guidance panel.

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

Abstract: Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.

Abstract: Disclosed herein are pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives. The pharmaceutical compositions are for targeted therapeutic applications including, but not limited to, treating cancer-related fatigue, apathy in Alzheimer's Disease, major depression, and attention deficit-hyperactivity disorder. Also disclosed are methods of synthesizing the pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives.

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: An electronic product testing system includes: a testing device configured to generate and to provide a digital image that includes a feature of a product being tested, and to provide product testing instruction for the product; and a tracking device configured for tracking a cursor movement with respect to the digital image, and/or a selection of an item in the digital image, and to generate product testing data based on a result of the tracking; wherein the tracking device is also configured to output the product testing data for storage in a non-transitory medium, the non-transitory medium having a database structure that is configured to store the product testing data in association with the digital image and the product testing instruction.

Abstract: A boot comprises: a shell comprising a first foamed polymeric material; a sock liner comprising a second foamed polymeric material, the sock liner having an exposed section and an enclosed section; and an adhesive layer affixing the shell and the enclosed section of the sock liner; wherein there is an absence of intermingling of the second surface of the enclosed section of the sock liner with the inner surface of the shell. Methods of making and using the boot are also provided.

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.