Abstract: Disclosed herein are polyethylene glycol (PEG)-lipids, functionalized PEG-lipids, and functionalized PEG-lipids that are conjugated to a binding moiety which can comprise an antibody antigen binding domain. Also disclosed are methods for synthesizing and functionalizing the PEG-lipids. The PEG-lipids are useful components lipid nanoparticles (LNP) used for the delivery of nucleic acids into living cells, in vivo or ex vivo. LNP comprising functionalized PEG-lipids that are conjugated to a binding moiety are useful as targeted LNP for delivering nucleic acids into cells or tissues expressing the ligand of the binding moiety.

Abstract: Described herein are optimally-modified GJB2 cDNA and associated genetic elements for use in recombinant adeno-associated virus (rAAV)-based gene therapy for the treatment of genetic hearing loss.

Abstract: The invention relates to a ring gear cable winch having a cable drum and a drive device for driving the cable drum, wherein the drive device comprises a ring gear connected to the cable drum in a rotationally fixed manner and a plurality of drive motors arranged distributed over the circumference of the ring gear, and each drive a drive pinion meshing with the ring gear, wherein the drive pinions are connected directly to the drive motors without gearing and rotate at the motor shaft speeds of the drive motors.

Abstract: A method may include presenting a user interface, the user interface including: a graph presentation area; and a graph link type confirmation area; executing a knowledge graph database search query; in response to the executing, receiving a set of tuple objects corresponding to relationships between entities in the knowledge graph database; populating the graph presentation area with representations of the entities and links connecting the representations of the entities; populating the graph link type confirmation area with a selectable user interface element configured to confirm a relationship of the relationships between entities; receiving activation of the selectable user interface element; and in response to receiving the activation, updating the graph presentation area.

Abstract: Aspects of the disclosure are directed to automatically drafting police reports using a collaborative artificial intelligence (AI) system that can reduce bias in policing. The collaborative AI system can receive sensor data associated with an occurrence to generate a recreation of the occurrence in near-real time as the occurrence is underway. The collaborative AI system can utilize the recreation to automatically draft a police report for the occurrence in an unbiased and comprehensive manner.

Abstract: Generative media content (e.g., generative audio) can be played back across multiple playback devices concurrently. A coordinator device can receive a multi-channel stream of media content, with at least some channels comprising generative media content. The coordinator device transmits each of the channels to a plurality of playback devices. A first playback device plays back a first subset of the channels according to first playback responsibilities and a second playback device plays back a second subset of the channels according to second playback responsibilities. The first and/or second playback responsibilities can be dynamically modified over time, for example in response to one or more input parameters.

Abstract: A computer implemented system for generation of performance analysis of digital advertising carried out on a global communications network that may be accessible by consumers is provided. The system may include a processor and one or more of a client database. The client database may include client data stored thereon. The client data may include a conversion rate, an average order value, and/or an incremental lift rate. The processor may be configured to identify a conversion rate score, identify an average order value score, and identify an incremental lift rate score. The processor may further be configured to generate an aggregated media value score that may be based on the conversion rate score, the average order value score, and the incremental lift rate score. The processor may also be configured to broadcast the aggregated media value score to a receiver.

Abstract: An electrical device includes an internal electrical conductor that extends along a longitudinal axis. An insulator is overmolded around the internal electrical conductor such that the insulator includes first and second insulator portions with a parting plane at an interface between the first and second insulator portions. The parting plane is oriented such that it intersects the longitudinal axis. The electrical device may include a low electrical stress area defined by an electrical shield, wherein the parting line may be disposed entirely within the low electrical stress area. The electrical device may be a switchgear that includes a vacuum interrupter assembly having a vacuum bottle surrounded by an insulating sleeve comprising first and second sleeve portions with a parting plane at an interface between the first and second sleeve portions. The parting plane is oriented such that it intersects the longitudinal axis.

Abstract: Embodiments of the present invention provide a system for optimizing configuration of resource upgrades. The system is configured for identifying entity resources that meet conditions associated with upgrading the entity resources, identifying rules associated with upgrading the entity resources, determining change windows for upgrading the entity resources based at least on the rules, generating a schedule for upgrading the entity resources based on the rules and the change windows, displaying the schedule for upgrading the entity resources to a user, via a dynamic editable user interface, prompting the user to provide an input associated with the schedule via the dynamic editable user interface, receiving the response from the user via the dynamic editable user interface, and automatically upgrading the entity resources based on the schedule and the response received from the user.

Abstract: The disclosure provides a nanoemulsion including an oil phase containing at least one cannabinoid and a water phase; wherein at least one of the oil phase and the water phase includes one or more emulsifying agents; and wherein the zeta potential of the nanoemulsion is less than about ?10 mV. Further provided are processes for preparing such nanoemulsions.

Abstract: An aqueous, intra-oral, nanoemulsion blend is provided that enhances mitochondrial performance in mammals when orally administered. The blend includes at least two different monolayer surfactant bound particle components and at least one bilayer water-core liposome component. The blend optionally may include a micelle.

Abstract: Sorbent for filtering a coolant in immersion cooling systems, such as those used to cool electronic components. Sorbent may comprise activated carbon sorbent materials that have a bulk oxygen content of about 1 wt. % to about 5 wt. %, a moisture level of at most about 1.5 wt. %, and a molasses number of at least about 150. Sorbents may be contained within an enclosure to convey coolant therethrough to remove conductive contaminants from the coolant.

Abstract: Various illustrative systems, devices, and methods for beverage machines are provided. In one exemplary implementation, a system includes a housing, a grinder, a portafilter, a filter basket, and a tamp. The grinder is disposed within the housing. The portafilter is removably coupled to the housing. The filter basket is configured to be removably disposed within the portafilter for receiving coffee grounds. The tamp is configured to be disposed within the housing and has a tamp head, a tamp body, and a spring.

Abstract: A plant display device is disclosed which can be anchored within a window and is capable of supporting several potted plants simultaneously. The plant display device comprises a pair of independent vertical bars aligned vertically on opposite sides of the window and clamped into place. Then, multiple horizontal bars are installed at different heights along the vertical length. Each horizontal bar can support several potted plant holders held in place by a nut and bolt fixture. Users can screw the nut and bolt fixtures onto the horizontal bars to display their potted plants within the circular holders. Users can display their plants in a custom manner without worry of the plants being dropped or knocked over by children, pets, etc.

Abstract: Foldable or flexible ear tags for animals are disclosed herein. An example ear tag includes a flexible member configured to adapt to an interior of an ear of an animal, a solar panel housed on a protruding segment of the flexible member, the solar panel is configured to maintain an upward-facing orientation for sunlight exposure when the electronic ear tag is attached to the ear, an electronics assembly mounted on a rigid member of the electronic ear tag, the electronics assembly having a controller having a processor and memory for receiving and processing data from a location sensor, and a biometric sensor that are in contact with the ear, and a strap extending from the flexible member, the strap being configured to fit over a top of the ear to prevent rotation of the electronic ear tag when a securement member is inserted through the strap, the ear, and the flexible member.

Abstract: Various illustrative systems, devices, and methods for beverage machines are provided. In one exemplary implementation, a system includes a portafilter, a filter basket, a funnel, and a tamp. The portafilter is configured to be removably coupled to a housing of a beverage machine. The filter basket is configured to be removably disposed within the portafilter for receiving coffee grounds. The funnel is configured to be removably mounted on the portafilter and has a passageway configured to receive the coffee grounds therein and to direct the coffee grounds into the filter basket. The tamp is slidably insertable into the passageway of the funnel and configured to advance through the funnel to press the coffee grounds in the filter basket.

Abstract: A method for variable electrostimulative behavior modification includes sensing placement of a first anatomical portion of a body in contact to a surface of a target object adapted. for behavior modification with a multiplicity of electrostimulative end points coupled to an energy source. The method additionally includes delivering an electrical neurostimulus through one of the end points nearest to the placement of the first anatomical portion in proximity to the surface the electrical neurostimulus including a waveform promoting a modification of behavior associated with the placement of the first anatomical portion in proximity to the surface. Thereafter, an anomalous characteristic of the sensed placement indicating a failure to modify the behavior may be detected and a profile of the waveform of the electrical neurostimulus changes to a different waveform in response to the anomalous characteristic of the sensed placement.

Abstract: A system for production of customizable refractory bricks in an automated fashion is described. The system receives refractory bricks, measures and performs quality control inspections and rejects out of specification bricks. The system planes the bricks to a consistent height and performs one or more machining operations to grind the bricks into a final shape before conveying the bricks for assembly in the order required for assembly rather than in a batch process.

Abstract: Systems, methods, and devices are described for efficient extraction of provenance information from database query execution logs. A set of event records extracted from one or more database query execution logs is received. Groups of related event records are identified, and each defined as an activity. For each activity, an activity data structure is generated based on the associated event records. The data structure encodes query execution dependencies for the activity. For each activity, runtime information is extracted by identifying and instantiating process entities and relationships based on the associated event records and activity data structure. For each activity, lineage information is extracted by identifying and instantiating dataset entities and their lineage relationships based on query text within the associated event records.

Abstract: In some embodiments, the instant invention provides a programmed system that includes at least the following components: a computer programmed with software instructions that include: code to periodically receive financial data of a plurality of customers from a plurality of financial-related entities related to a plurality of financial assets, code to consolidate the financial data into a consolidated financial data; code to analyze the consolidated financial data with at least one address-matching program; code to associate each record of the consolidated financial data with a respective eleven digit postal code to result in an address-enriched consolidated financial data; code to anonymize the address-enriched consolidated financial data to form an anonymous address-enriched consolidated financial data; and code to link information of the anonymous address-enriched consolidated financial data across a plurality data relationship to form a consolidate household view for each respective eleven digit postal c