Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11R?, and methods of medical treatment and prophylaxis using the same.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: An example method includes providing third party access to listen to a call and the ability to inject audio into an isolated audio portion of the call by using a switch controller within a mobile virtual network operator (MVNO) platform. The switch controller can to separate a call into multiple audio portions. The example method can further include collecting and warehousing call metadata and providing access to isolated audio portions via an external database, web object, API, etc.

Abstract: Disclosed herein are systems, methods, and non-transitory computer-readable storage media for detecting events occurring to an article at a remote location using low-power event detection circuitry and transmission of event detection messages over a network.

Abstract: An aircraft including a wing and a wing tip device is disclosed. The wing tip device is moveable between a flight configuration for use during flight and a ground configuration for use during ground-based operations. In the ground configuration the wing tip device is folded inwardly from the flight configuration such that the span of the aircraft is reduced. The wing tip device is connected to the wing along a hinge axis by spar beams of the wing tip device, one of the beams being mounted for pivoting about a fixed axis and the other beam being mounted on a spherical bearing to provide greater freedom of movement. Various actuator arrangements may be provided to pivot the wing tip device.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A wellbore isolation system is disclosed. The wellbore isolation system includes a junction positioned at an intersection of a first wellbore and a second wellbore, and a deflector disposed in the junction such that a path into the first leg of the junction is obstructed and engaged with the first leg of the junction to form a fluid and pressure tight seal. The junction includes a first leg extending downhole into the first wellbore, and a second leg extending downhole into the second wellbore. The deflector includes a channel extending axially through the deflector, and a degradable plug disposed in the channel and engaged with the channel to prevent fluid flow through the channel.

Abstract: An aircraft wing having a fixed wing with a wing tip device. The wing tip device is movable between a flight configuration for use during flight, and a ground configuration for use during ground-based operations. The wing has a master flight control surface associated with the fixed wing and a slave flight control surface associated with the wing tip device. An interface between the master flight control surface and the slave flight control surface is arranged to provide a rigid connection between the master flight control surface and slave flight control surface when the wing tip device is in the flight configuration. Moving the master control surface about a control axis causes the slave control surface to be moved about the control axis. The interface is arranged to de-couple the slave and master control surfaces when the wing tip device is moved from the flight configuration into the ground configuration.

Abstract: Methods of treating and preventing hepatotoxicity through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A method of assembling a wing tip device to a wing of a powered aircraft including: providing a wing tip, providing a wing tip device, pivotably attaching the wing tip device to the wing at a first position, pivoting the wing tip device about the first position, and attaching the wing tip device to the wing at a second position spaced from the first position.

Abstract: Systems, methods, and non-transitory computer-readable storage media for gathering activity data describing a user's activities from one or more activity sensors and using the activity data to predict immune-response to the activity. Predicting immune-response can involve creating, personalizing, and refining immune-response prediction models based on demographic user data, activity data, blood sample data, personal genetic information.

Abstract: IL-11Ra antibodies are disclosed. Also disclosed are compositions comprising the IL-11Ra antibodies, and methods using the IL-11Ra antibodies.

Abstract: IL-11 antibodies are disclosed. Also disclosed are compositions comprising the IL-11 antibodies, and methods using the IL-11 antibodies.

Abstract: Provided, in one aspect, is a windowed deflector assembly. The windowed deflector assembly according to this aspect includes a tubular housing, the tubular housing having a window there through, a wrap covering the window, and a deflector coupled to or formed integrally as part of the tubular housing.

Abstract: Systems, methods, and non-transitory computer-readable storage media for gathering activity data describing a user's activities from one or more activity sensors and using the activity data to predict immune-response to the activity. Predicting immune-response can involve creating, personalizing, and refining immune-response prediction models based on demographic user data, activity data, blood sample data, personal genetic information.

Abstract: A wellbore isolation system includes a junction positioned at an intersection of a first wellbore and a second wellbore, and a deflector disposed in the junction such that a path into the first leg of the junction is obstructed and engaged with the first leg of the junction to form a fluid and pressure tight seal. The junction includes a first leg extending downhole into the first wellbore, and a second leg extending downhole into the second wellbore. The deflector includes a channel extending axially through the deflector, and a degradable plug disposed in the channel and engaged with the channel to prevent fluid flow through the channel.

Abstract: Some methods enable a computer to receive location information from a device and determine a coverage region for the device. The device's coverage region is the area within range of a wireless signal coming from the device. The computer can determine that part of the device's coverage region covers part of a specified region and instruct the device to provide wireless access to a network associated with the first region.

Abstract: A method of manufacturing a foldable aerodynamic structure, such as a wing, for an aircraft. The wing (1) including an inner region (1) and an outer region (3) rotatable relative to the inner region between a flight configuration and a ground configuration. The method includes designing the foldable aerodynamic structure by determining the location and orientation of an Euler axis of rotation (11) about which the outer region rotates to achieve the ground configuration and determining a cut plane (13), perpendicular to that Euler axis, separating the inner and outer regions; and iteratively repeating this process until a preferred cut plane (13) is obtained that satisfies at least one design criteria.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.