Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.

Abstract: Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.

Abstract: The invention provides an apparatus, system, and method for cluster-wide peer recovery in the event of a computer failure. A failure of a first computer is detected and a recovery module is registered as the first computer. In one embodiment, the recovery module is a peer computer. The recovery module retrieves a privately held undo log data through the authorized assumption of the failure identity associated with the failed first computer, backs out in-flight transaction updates of the first computer, and frees up data resources locked by the first computer.

Abstract: The present invention is directed to therapeutic compounds which have dual activity as agonists of GPR119 and inhibitors of DPP-IV and are useful for the treatment of metabolic disorders including type II diabetes.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.

Abstract: A method of controlling an air to fuel ratio of an internal combustion engine may include receiving a request for a modification of a first flow of fuel to at least one combustion chamber, modifying the first flow of fuel in response to the request, receiving a first signal indicative of a first air supply condition, displacing a second flow of fuel in response to receiving the signal and controlling the modification of the first flow of fuel by the displacement of the second flow of fuel.

Abstract: An apparatus, system, and method are disclosed for preserving cluster level serialization during file server serialization reinitialization. The apparatus includes a permission request module, a cluster negotiation module, and a completion notification module. The permission request module communicates a permission request to a remote file server in anticipation of a reinitialization of a local file server. The cluster negotiation module implements a reinitialization protocol on the remote file server during the reinitialization of the local file server. The completion notification module notifies the remote file server when the reinitialization of the local file server is complete. The apparatus, system, and method beneficially facilitate continued serialization negotiation among the remote file servers during the reinitialization of the serialization data on the local file server and, thereby, preserve the integrity of shared data resources.

Abstract: An apparatus, system, and method are disclosed for suspending a data access request during serialization reinitialization of a file server. The apparatus includes a request recognition module, an availability module, and a suspension module. The request recognition module recognizes a request to be processed by a file server. The availability module determines if the file server is available. The suspension module suspends the data access request if the file server is not available due to serialization reinitialization. In one embodiment, the suspension module implements a hardware interrupt delay loop to suspend an interruptible data access request, such as an application request. In another embodiment, the suspension module queues a non-interruptible data access request and notifies the operating system, for example, that the non-interruptible request has been initiated.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Abstract: Compounds of formula (I): R1-A-V—B—R2, wherein V is phenyl or a 6-membered heteroaryl ring containing up to three N-atoms, or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.

Abstract: A method and system for configuring wireless communication of survey sensors and controllers is recited. In one embodiment, a survey device controller is configured to receive a first wireless communication comprising a sequence indicating that a survey device is configured to participate in an automatic configuration process with the survey device controller. The system further comprises the survey device which is configured to generate a second wireless communication indicating the reception of a selection event to communicatively couple the survey device with the survey device controller. The survey device controller is further configured to automatically initiate a wireless communication connection comprising the survey device controller and the survey device in response to receiving the second wireless signal contemporaneous with receiving a signal which is generated by the survey device controller to communicatively couple the survey device controller with the survey device.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Abstract: An apparatus, system, and method are disclosed for reinitializing serialization data in a file server. The apparatus includes a failure recognition module, a discard module, and a serialization module. The failure recognition module recognizes a file system serialization failure on a file server. Upon recognition of the serialization failure, the discard module discards existing serialization data located in a first memory address space, such as a file server address space. In certain embodiments, the entire file server address space may be destroyed by the operating system. The serialization module then generates new serialization data from existing connection/position data. The connection/position data is located in a second address space, such as a client address space, that is maintained during the serialization reinitialization process.

Abstract: Systems and methods that regulate range of access to personal information of a mobile unit's owner. The access control component can designate granularity for access levels and/or a spectrum of access modes—(as opposed to a binary choice of full access or no access at all). Such access can be based on a spectrum and/or discrete trust relationship between the owner and user of the mobile unit. A profile definition component can exploit an owner's trust relationships to designate levels of security. The profile definition component can further define a profile based on a set of applications, such as entertainment mode, browser mode, and the like.

Abstract: Apparatus (10) for applying adhesive to a surface to be tiled has a container (11) for the adhesive and a pair of opposed end walls (12,14) at least one of which is removable. The container has an outlet port (24) and one end wall (14) supports a plunger (19,23) for driving adhesive through the port (24) out of the container A drive mechanism such as a hydraulic ram (17) is provided on that one end wall (14) to cause movement of the plunger (19,23). A multi-outlet nozzle (26) for adhesive is connected by a duct (25) to the outlet port so that a plurality of beads of the adhesive are laid on the surface to be tiled.

Abstract: A tiling adhesive application system comprises a backing sheet with a series of parallel grooves extending thereacross and each carrying a bead of tiling adhesive. A release sheet is bonded to the edge margins of the backing sheet to form a sealed package. The backing sheet is transparent and of the same size as a tile to be adhered to a wall. The release sheet is peeled away to expose the adhesive which is then applied to the wall while carried by the backing sheet, whereafter the backing sheet is lifted away from the wall leaving the adhesive ready to bond a tile to the wall.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.