Patents by Inventor Subhra Mohapatra

Subhra Mohapatra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12102635
    Abstract: The present disclosure relates to methods of using palmitoylation inhibitors for reducing or treating enveloped virus infections.
    Type: Grant
    Filed: October 6, 2022
    Date of Patent: October 1, 2024
    Assignees: University of South Florida, The Florida International University Board of Trustees
    Inventors: Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
  • Publication number: 20240293432
    Abstract: A composition including a cannabinoid and an anti-cancer agent and methods of treating lung cancer using said composition.
    Type: Application
    Filed: March 4, 2024
    Publication date: September 5, 2024
    Inventors: Subhra MOHAPATRA, Shyam MOHAPATRA, Ryan Green
  • Publication number: 20240294925
    Abstract: Methods are disclosed for auditory dysfunction by administration of a therapeutic agent and stem cells. The therapeutic agent is chosen from disclosed agents that target the CCL20-CCR6 axis. Further disclosed are treatment protocols of said therapeutic agent and stem cells. The method of treatment is disclosed to be treatment following a traumatic brain injury.
    Type: Application
    Filed: March 4, 2024
    Publication date: September 5, 2024
    Inventors: Subhra MOHAPATRA, Shyam MOHAPATRA, Courtney PENN
  • Publication number: 20240293430
    Abstract: The present disclosure provides methods of treating cancer in a subject in need thereof comprising administering to the subject a therapeutically effective amount of withaferin A and an immune checkpoint blocker. Further, the cancer to be treated may be resistant, have developed resistance, or may be susceptible to resistance to treatment with the immune checkpoint blocker alone or in combination with another therapeutic agent other than withaferin A.
    Type: Application
    Filed: March 4, 2024
    Publication date: September 5, 2024
    Inventors: Subhra Mohapatra, Shyam MOHAPATRA, Roukiah Khalil
  • Patent number: 11951152
    Abstract: This disclosure is directed to therapeutic compositions, and more particularly to microparticle compositions for the controlled delivery of telmisartan and actinomycin D.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 9, 2024
    Assignees: University of South Florida, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Eleni Markoutsa, Alejandro J. Gonzalez, Heta N. Jadhav
  • Publication number: 20240100047
    Abstract: A nanosystem and methods of treating, including prophylactically, coronavirus infections, such as those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by administering such nanosystem to a patient is presented. The nanosystem may be comprised of a single or a combination of therapeutic agents, optionally encapsulated in a nanoparticle having a targeting moiety directed to the particular coronavirus. For CoV-2 infections, at least one therapeutic agent, such as the dual DPP4/ACE2 inhibitor sitagliptin, may optionally be encapsulated within a nanoparticle having a fatty acid such as linoleic acid, as the targeting moiety. Administration can occur intranasally prior to infection for prophylactic treatment or post-infection for treatment of the viral infection.
    Type: Application
    Filed: November 14, 2023
    Publication date: March 28, 2024
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Karthick Mayilsamy, Eleni Markoutsa, Andrew McGill
  • Publication number: 20240065983
    Abstract: A multi-functional broad-spectrum antiviral and anti-inflammatory nanosystem and methods of treating, including prophylactically, coronavirus infections, such as those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by administering such nanosystem to a patient is presented. The nanosystem may be comprised of a combination of therapeutic agents directed to the particular coronavirus encapsulated in a nanoparticle that is surface coated with a targeting moiety. For CoV-2 infections, an antiviral such as the PPAR-? agonist leriglitazone (LG) and an siRNA targeting a conserved sequence of the virus can be encapsulated within a nanoparticle surface coated with a fatty acid such as linoleic acid, as the targeting moiety. Administration can occur intranasally prior to infection for prophylactic treatment or post-infection for treatment of the viral infection.
    Type: Application
    Filed: October 27, 2023
    Publication date: February 29, 2024
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Karthick Mayilsamy, Eleni Markoutsa, Andrew McGill
  • Patent number: 11911481
    Abstract: This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: February 27, 2024
    Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF SOUTH FLORIDA
    Inventors: Eleni Markoutsa, Subhra Mohapatra, Shyam Mohapatra
  • Patent number: 11884906
    Abstract: A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture well, as well as from the culture well to the outlet well. Due to the fluid flow from the plate to the chip, and from the inlet well to the outlet well on the chip through the culture well, target cell (tumoroid) growth is promoted within the culture well.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: January 30, 2024
    Assignee: University of South Florida
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang
  • Publication number: 20230364147
    Abstract: The present invention pertains to a strategy of selectively targeting oncolytic virotherapy, using either naturally occurring or genetically modified viruses by packaging them in mesenchymal stem cells (MSCs). The present invention concerns MSCs, compositions comprising the MSCs, and methods of using the MSCs for treatment of cancer and for lysing or inducing apoptosis of cancer cells in vitro or in vivo.
    Type: Application
    Filed: March 20, 2023
    Publication date: November 16, 2023
    Inventors: SHYAM S. MOHAPATRA, SUBHRA MOHAPATRA
  • Patent number: 11766429
    Abstract: A method of treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), otherwise known as COVID-19, infection by administering nicotinic receptor antagonists and/or PPAR-? agonists is presented. A combination of mecamylamine, or an isomer thereof, and pioglitazone synergistically reduces replication of SARS-CoV-2 in virus-infected cells and also synergistically reduces inflammatory cytokines such as IL-6, IL-?, and TNF?, which have been associated with SARS-CoV-2 infection.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: September 26, 2023
    Assignee: University of South Florida
    Inventors: Paul Ronald Sanberg, Christian Bernard Brechot, Shyam S. Mohapatra, Subhra Mohapatra
  • Publication number: 20230285442
    Abstract: Described herein are methods for neutralizing a virus. The methods involve interacting the virus with an oligochitosan or a derivative thereof having a molecular weight of at least 1 KDa and a degree of deacetylation of at least 1%. The methods described herein have numems applications with respect to the treatment or prevention of viral infections caused by a human immunodeficiency virus, a paramyxovirus, an orthomyxovirus, a coronavirus, or a filovirus as well as the detection and quantification of viral load. Also described herein are the synthesis of the oligochitosan and derivatives thereof.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 14, 2023
    Inventors: Subhra MOHAPATRA, Shyam S. MOHAPATRA, Julio GARAY, Mazen HANNA, Karthick MAYILSAMY
  • Patent number: 11752220
    Abstract: A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: September 12, 2023
    Assignees: The United States Government as Represented by the Department of Veterans Affair, University of South Florida
    Inventors: Shyam S. Mohapatra, Subhra Mohapatra, Eleni Markoutsa
  • Patent number: 11685885
    Abstract: A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture well, as well as from the culture well to the outlet well. Due to the fluid flow from the plate to the chip, and from the inlet well to the outlet well on the chip through the culture well, target cell (tumoroid) growth is promoted within the culture well.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: June 27, 2023
    Assignee: University of South Florida
    Inventors: Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang
  • Publication number: 20230135119
    Abstract: The present disclosure relates to methods of using palmitoylation inhibitors for reducing or treating enveloped virus infections.
    Type: Application
    Filed: October 6, 2022
    Publication date: May 4, 2023
    Inventors: Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
  • Patent number: 11607426
    Abstract: The present invention pertains to a strategy of selectively targeting oncolytic virotherapy, using either naturally occurring or genetically modified viruses by packaging them in mesenchymal stem cells (MSCs). The present invention concerns MSCs, compositions comprising the MSCs, and methods of using the MSCs for treatment of cancer and for lysing or inducing apoptosis of cancer cells in vitro or in vivo.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 21, 2023
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Shyam S. Mohapatra, Subhra Mohapatra
  • Publication number: 20220409765
    Abstract: Method for increasing efficiency of a pathogen inactivation via enhancing UVC light absorption at such pathogen by multiple diffuse scattering of the light at a wall defining a substantially closed volume, thereby increasing a number of angles at which the pathogen is being irradiate as compared with a direct irradiation of the pathogen with a beam of such light.
    Type: Application
    Filed: June 27, 2022
    Publication date: December 29, 2022
    Inventors: Dmitri VORONIN, Shyam MOHAPATRA, Subhra MOHAPATRA, Sharad AMBARDAR, Mark HOWELL, Karthick MAYILSAMY
  • Publication number: 20220398458
    Abstract: Disclosed are various embodiments of systems and methods of deep learning for colorectal polyp screening and providing a prediction of neoplasticity of a polyp. A video of a colonoscopy procedure can be captured. Frames from the video or images associated with the colonoscopy procedure can be extracted. A model for classifying objects that appear in the frames or the images can be obtained. A classification can be determined for a polyp that appears in at least one of the frames or images based on applying the frames or images to an input layer of the model.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 15, 2022
    Inventors: Shyam S. MOHAPATRA, Subhra MOHAPATRA, Anmol WARMAN
  • Publication number: 20220395477
    Abstract: The present disclosure relates to compositions and uses thereof for preventing and treating respiratory syncytial vims (RSV) infection. In some aspects, disclosed herein is a method for preventing or treating respiratory syncytial vims (RSV) infection in a subject, comprising administering to the subject a therapeutically effective amount of a composition comprising a short-chain fatty acid.
    Type: Application
    Filed: October 29, 2020
    Publication date: December 15, 2022
    Inventors: Shyam S. MOHAPATRA, Subhra MOHAPATRA, Andrew Robert MCGILL, Eleni MARKOUTSA
  • Publication number: 20220349878
    Abstract: The present disclosure provides novel gravitational flow assays for detecting an antigen in a biological sample using DNA-capture sequences. Specifically, gravitational flow assays and methods of detecting viruses, including coronaviruses, are provided.
    Type: Application
    Filed: April 29, 2022
    Publication date: November 3, 2022
    Inventors: Subhra MOHAPATRA, Shyam MOHAPATRA, Ryan GREEN