Patents by Inventor Sun-Chang Kim

Sun-Chang Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11365388
    Abstract: Provided is a method of producing a novel microorganism having a minimal genome. In particular, provided are a method of producing a novel microorganism having a smaller genome size than a wild-type, the method including the step of culturing the microorganism in a medium containing LB broth with stepwise decreasing concentrations of the LB broth; and a novel microorganism having a smaller genome size than a wild-type, produced by the above method. Despite the small genome size, the novel microorganism of the present disclosure may have a high growth rate, pyruvate production capacity, and protein translation efficiency thereby being usefully applied to industry such as production of recombinant proteins or pyruvate.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: June 21, 2022
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sun-Chang Kim, Byung-Kwan Cho, Donghui Choe, Bong Hyun Sung, Jun Hyoung Lee
  • Patent number: 11186616
    Abstract: Provided are a recombinant yeast having improved ability to produce ginsenoside, which is prepared by overexpressing INO2 and INO4 or deleting OPT1 in a yeast having ability to produce ginsenoside, a method of preparing the yeast, and a method of producing ginsenoside by using the yeast.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: November 30, 2021
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Ju Young Lee, In Seung Jang, Seohyun Kim, Sun-Chang Kim, Suk Chea Jung, Jong Geon Jegal
  • Patent number: 11046990
    Abstract: The present invention relates to recombinant yeast, in which the productivity of ginsenoside is enhanced by overexpressing CPR5, PDI1, or ERO1 in yeast having the productivity of ginsenosides; a method for preparing the yeast; and a method for producing ginsenosides using the yeast.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: June 29, 2021
    Inventors: Sun-Chang Kim, Ju Young Lee, In Seung Jang, Seohyun Kim, Jong Geon Jegal
  • Publication number: 20210008088
    Abstract: The present invention relates to a pharmaceutical composition, a health functional food, and a feed composition for the prevention, improvement, or treatment of non-alcoholic liver disease or insulin resistance comprising ginsenoside F2. The pharmaceutical composition according to the present invention comprising ginsenoside F2 can inhibit the adipogenesis and lipid accumulation in the liver, improve insulin sensitivity, inhibit the expression of inflammatory cytokines such as TNF-?, IL-?, and IL-6 in the Kupffer cell, inhibit the expression of endocannabinoid synthase, thus capable of effectively preventing or treating non-alcoholic liver disease or insulin resistance.
    Type: Application
    Filed: July 27, 2020
    Publication date: January 14, 2021
    Applicant: Intelligent Synthetic Biology Center
    Inventors: Won Il Jeong, Sun Chang Kim, Ju Yeon Jung, Wan Taek Im
  • Publication number: 20210002334
    Abstract: Provided are a recombinant yeast having improved ability to produce ginsenoside, which is prepared by overexpressing INO2 and INO4 or deleting OPT1 in a yeast having ability to produce ginsenoside, a method of preparing the yeast, and a method of producing ginsenoside by using the yeast.
    Type: Application
    Filed: September 21, 2020
    Publication date: January 7, 2021
    Inventors: Ju Young LEE, In Seung JANG, Seohyun KIM, Sun-Chang KIM, Suk Chea JUNG, Jong Geon JEGAL
  • Publication number: 20200239831
    Abstract: Provided is a method of producing a novel microorganism having a minimal genome. In particular, provided are a method of producing a novel microorganism having a smaller genome size than a wild-type, the method including the step of culturing the microorganism in a medium containing LB broth with stepwise decreasing concentrations of the LB broth; and a novel microorganism having a smaller genome size than a wild-type, produced by the above method. Despite the small genome size, the novel microorganism of the present disclosure may have a high growth rate, pyruvate production capacity, and protein translation efficiency thereby being usefully applied to industry such as production of recombinant proteins or pyruvate.
    Type: Application
    Filed: January 24, 2020
    Publication date: July 30, 2020
    Inventors: Sun-Chang Kim, Byung-Kwan Cho, Donghui Choe, Bong Hyun Sung, Jun Hyoung Lee
  • Patent number: 10682366
    Abstract: The present invention relates to compositions for enhancing innate immunity, comprising ginsenoside F1 as an active ingredient. Specifically, the composition according to the present invention promotes degranulation activity and cell-killing activity of natural killer cells, and increases expressions of cell-killing factors, thereby being effectively used as an innate immunity enhancer.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: June 16, 2020
    Assignee: INTELLIGENT SYNTHETIC BIOLOGY CENTER
    Inventors: Sun Chang Kim, Hun Sik Kim
  • Publication number: 20190352649
    Abstract: The present invention relates to yeast with an enhanced ginsenoside-producing ability prepared by changing Ald2, Ald6, Zwf1, and Zms1, a method of preparing the yeast, and a method for producing ginsenosides using the yeast.
    Type: Application
    Filed: October 31, 2018
    Publication date: November 21, 2019
    Inventors: Sun-Chang Kim, Ju Young Lee, Jae Eung Kim, In Seung Jang, Jong Geon Jegal
  • Patent number: 10406204
    Abstract: The present invention provides an antimicrobial peptide polymer comprising at least one monomer which is digested by pepsin, a multimeric antimicrobial peptide complex comprising the polymer and a cell surface anchoring motif linked to the polymer, an antimicrobial microorganism displaying the multimeric antimicrobial peptide complex, an antimicrobial composition comprising the same, a method of treating an infectious disease caused by bacteria, yeast or fungi by administering the antimicrobial composition, and a method for producing the antimicrobial microorganism. According to the invention, living microorganisms displaying an antimicrobial peptide on the cell surface thereof may be administered in vivo without having to lyse the microbial cell and isolate and purify the antimicrobial peptide, so that the antimicrobial peptide exhibits antimicrobial activity. Thus, the antimicrobial peptide may be produced at significantly reduced costs so that it may have widespread use.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: September 10, 2019
    Assignees: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, INTELLIGENT SYNTHETIC BIOLOGY CENTER
    Inventors: Sun-Chang Kim, Ju Ri Shin, Ki Jung Lim, Da Jung Kim, Young Woong Lee, Su A Jang, Bong Hyun Sung
  • Patent number: 10391111
    Abstract: Provided are a pharmaceutical composition for preventing or treating cervical cancer including gypenoside LXXV or a pharmaceutically acceptable salt thereof as an active ingredient, a method of preventing or treating cervical cancer including administering the pharmaceutical composition to a subject excluding humans, a health functional food composition for preventing or improving cervical cancer including gypenoside LXXV as an active ingredient, and a feed composition for preventing or improving cervical cancer including gypenoside LXXV as an active ingredient.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: August 27, 2019
    Assignee: Intelligent Synthetic Biology Center
    Inventors: Chang Hao Cui, Wan Taek Im, Sun Chang Kim
  • Patent number: 10391110
    Abstract: The present invention relates to a pharmaceutical composition containing ginsenoside F1 or Rh1 for preventing or treating vascular leak syndrome, to a method for treating vascular leak syndrome using the pharmaceutical composition, and to a food composition containing ginsenoside F1 or Rh1 for preventing or ameliorating vascular leak syndrome. The ginsenoside F1 or Rh1 provided in the present invention can promote angiogenesis and suppress vascular leakage, and thus can be widely utilized in the effective prevention or treatment of vascular leak syndrome.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: August 27, 2019
    Assignee: Intelligent Synthetic Biology Center
    Inventors: Ho Min Kim, Ji In Kang, Sun Chang Kim, Chang Hao Cui
  • Patent number: 10376530
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating Gleevec-resistant leukemia, containing, as an active ingredient, ginsenoside F1 or Rg3 which exhibits a preventive or therapeutic effect on Gleevec-resistant leukemia through enhancing cell killing activity of NK cells; a method for treating Gleevec-resistant leukemia comprising a step of administering the pharmaceutical composition; and a food composition for preventing or ameliorating Gleevec-resistant leukemia. Since the pharmaceutical composition of the present invention can effectively treat leukemia that exhibits resistance to conventional Gleevec, the pharmaceutical composition can be widely used for effective leukemia treatment.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: August 13, 2019
    Assignee: Intelligent Synthetic Biology Center
    Inventors: Sun Chang Kim, Hun Sik Kim
  • Patent number: 10363262
    Abstract: The present invention relates to a composition for wound healing or skin regeneration comprising gypenoside 75 (gypenoside LXXV) as an active ingredient.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: July 30, 2019
    Assignee: INTELLIGENT SYNTHETIC BIOLOGY CENTER
    Inventors: Sun-Chang Kim, Sungjoo Park, Eun Su Ko
  • Publication number: 20190224278
    Abstract: The present invention relates to a method for preparing an antimicrobial peptide with enhanced adhesion, and an antimicrobial coating method of the antimicrobial peptide with enhanced adhesion. The antimicrobial coating method of the present invention can be widely used as a method for adding an antimicrobial property to medical products and industrial products, because the method is capable of coating the antimicrobial peptide with enhanced adhesion, which has no cytotoxicity and possesses an excellent antimicrobial activity, on various surfaces with optimal efficiency.
    Type: Application
    Filed: October 30, 2018
    Publication date: July 25, 2019
    Inventors: Sun-Chang Kim, Young Eun Hwang, Le Minh Bui
  • Patent number: 10330672
    Abstract: The present invention relates to a method for screening an activator of mitochondrial activity by using gypenoside-treated cells, to a composition for screening an activator of mitochondrial activity, comprising the gypenoside, and to a kit comprising the composition. By using the method for screening an activator of mitochondrial activity of the present invention, it is possible to effectively discover a preparation which can substantially promote the mitochondrial activity, and thus the method is expected to be widely used in developing a therapeutic agent for diseases caused by mitochondrial activity inhibition.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 25, 2019
    Assignee: INTELLIGENT SYNTHETIC BIOLOGY CENTER
    Inventors: Sun Chang Kim, Chan Bae Park, Soon Jang Lee
  • Patent number: 10307436
    Abstract: Provided are a food composition and a feed composition for removing amyloid plaques, each composition including ginsenoside F1, in which ginsenoside F1 is effective for removing amyloid plaques in the hippocampal area of the brain.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: June 4, 2019
    Assignee: INTELLIGENT SYNTHETIC BIOLOGY CENTER
    Inventors: Sun Chang Kim, Jin Hee Han, Bong Hwan Park
  • Patent number: 10301654
    Abstract: Provided is a method of preparing cinnamaldehyde by using a recombinant microorganism.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: May 28, 2019
    Assignee: INTELLIGENT SYNTHETIC BIOLOGY CENTER
    Inventors: Ki Jun Jeong, Sun Chang Kim, Hyun Bae Bang, Yoon Hyeok Lee, Suk Chae Jung
  • Publication number: 20190119688
    Abstract: Provided are a composition for solubilizing a target protein, including an expression cassette including a promoter and a gene encoding a fusion protein of a chaperone and an RNA-binding domain or an expression vector including the expression cassette; a transformant including the expression cassette or the expression vector; a kit including the composition or the transformant; and a method for producing the target protein by using the same.
    Type: Application
    Filed: January 31, 2018
    Publication date: April 25, 2019
    Inventors: Jun Hyoung LEE, Sun-Chang KIM, Almando Geraldi
  • Publication number: 20190112629
    Abstract: The present invention relates to a method for mass production of ginsenoside Rh2-Mix. The present invention includes treating PPD-Mix with an organic acid and heat to obtain Rg3-Mix and treating the obtained Rg3-Mix using a recombinant GRAS strain in the Rg3-Mix to produce Rh2-Mix, and thereby facilitates the mass production of ginsenoside Rh2-Mix using ?-glucosidase, which has been known to be difficult. Further, the present invention is advantageous in that the Rh2-Mix can be produced in high yield even at high temperatures, and mass production thereof for industrial purposes is practical as the production process is simple and more economical than direct use of an enzyme.
    Type: Application
    Filed: February 23, 2018
    Publication date: April 18, 2019
    Inventors: Sun-Chang KIM, Wan Taek IM, Chang-Hao CUI
  • Publication number: 20190048380
    Abstract: The present invention relates to recombinant yeast, in which the productivity of ginsenoside is enhanced by overexpressing CPR5, PDI1, or ERO1 in yeast having the productivity of ginsenosides; a method for preparing the yeast; and a method for producing ginsenosides using the yeast.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 14, 2019
    Inventors: Sun-Chang Kim, Ju Young Lee, In Seung Jang, Seohyun Kim, Jong Geon Jegal