Abstract: Provided is a method for producing highly functional artificial organs, including blood vessels capable of carrying perfusate, by using aptamers. The aptamers, according to the presently claimed subject matter, enhance blood vessel adhesion ability, viability, angiogenesis potential, and the like when used as a coating agent of a decellularized scaffold, and thus can more efficiently reconstruct vasculature than existing antibodies. Therefore, a vascularized artificial liver produced using the aptamers exhibits the effects of reducing thrombogenesis in vivo as well as enhancing liver function, and thus is expected to be applied as a method for treating diseases by using artificial organs produced using the aptamers according to the presently claimed subject matter.

Abstract: The present invention provides a pharmaceutical composition for preventing or treating inflammatory diseases, containing, as an active ingredient, stem cells overexpressing SOD3. The present inventor has ascertained that mesenchymal stem cells (MSCs) overexpressing SOD3 have a stronger antioxidant activity and immune regulatory function than normal MSCs, and thus the MSCs overexpressing SOD3 can be an effective treatment agent for inflammatory diseases, autoimmune diseases, organ transplant rejection and the like.

Abstract: The present disclosure relates to a device for fastening a lockbolt, the device comprising: a lockbolt gun including a body unit having a grip therein for pulling the lockbolt and a gripping unit protruding from a lower portion of the body unit and having an operation switch installed on the outside, wherein a hydraulic supply flow path for supplying hydraulic pressure for driving the grip, a hydraulic discharge flow path for discharging hydraulic pressure supplied to the grip, and an air supply flow path for supplying pneumatic pressure to the operation switch are installed in the gripping unit, and a discharge hole is formed outside the gripping unit to discharge air from the air supply flow path when the operation switch is operated; a driving force supply unit having a hydraulic supply pump that supplies hydraulic pressure to the hydraulic supply flow path, a hydraulic recovery pump that recovers hydraulic pressure discharged from the hydraulic discharge flow path, and an oil tank that supplies oil to the

Abstract: A crampon includes a crampon base for fitting to an underside of an item of footwear, such as a shoe or a boot. A harness extends from the crampon base and may be attached to the crampon base using rivets. The harness and the crampon base define a space for receiving the item of footwear. The crampon base comprises at least one cleat assembly with a cleat base embedded within the crampon base. One or more spikes extend from the cleat base.

Abstract: An additive, a non-aqueous electrolyte for a lithium secondary battery including the same, and a lithium secondary battery including the same are disclosed herein. In some embodiments, an additive includes at least one compound selected from the group consisting of the compounds represented by Formula 1 and Formula 2. In some embodiments, a non-aqueous electrolyte includes a lithium salt, an organic solvent, and an additive including at least one compound selected from the group consisting of the compounds represented by Formula 1 and Formula 2.

Abstract: Modified exosomes are disclosed that include an exosome and a targeting modality that extends outwardly from a surface membrane of the exosome. Also disclosed are methods of producing and using the modified exosomes.

Abstract: The present disclosure relates to a lithium secondary battery including: a non-aqueous electrolyte including a lithium salt, an organic solvent, a first additive represented by Chemical Formula 1 and a second additive represented by Chemical Formula 2; a positive electrode including a positive electrode active material including a lithium composite transition metal oxide having a nickel content of 70 mol % or more among a total transition metal content; a negative electrode including an negative electrode active material; and a separator interposed between the positive electrode and the negative electrode.

Abstract: The present invention relates to a coolant heater comprising: a heating element for heating coolant; a first housing for accommodating the heating element; a cover plate for sealing the first housing in which the heating element is accommodated; a temperature fuse provided in an external space formed by coupling the first housing and the cover plate, and disposed to be adjacent to the cover plate; and a second housing for pressing the temperature fuse so as to pressurize the same toward the cover plate, wherein overheat sensing responsiveness of the heating element is improved such that the overheat of the heating element can be prevented, and failure factors in a part in which the temperature fuse is coupled are reduced such that a durability is improved.

Abstract: A crampon includes a crampon base for fitting to an underside of an item of footwear, such as a shoe or a boot. A harness extends from the crampon base and may be attached to the crampon base using rivets. The harness and the crampon base define a space for receiving the item of footwear. The crampon base comprises at least one cleat assembly with a cleat base embedded within the crampon base. One or more spikes extend from the cleat base.

Abstract: Disclosed is a method for producing a stem cell with enhanced efficacy, a stem cell produced thereby, and a method for treating a disease using the same. According to the present invention, sizes of stem cells may be reduced and proliferation ability, differentiation potency, migration ability, and angiogenic potential of stem cells may be significantly enhanced by applying a culturing method provided herein. Thus the present invention may be usefully applied to development of therapeutic agents using stem cells.

Abstract: An electrolyte solution additive, an electrolyte solution including the same, and a lithium secondary battery including the same are disclosed herein. In some embodiments, an electrolyte solution additive includes a compound represented by Formula 1: Wherein X is oxygen (O) or sulfur (S), and R is a substituted or unsubstituted alkyl group having 1 to 5 carbon atoms or N(R1)2, wherein R1 is hydrogen or a substituted or unsubstituted alkyl group having 1 to 5 carbon atoms. The additive has an excellent effect of scavenging a decomposition product generated from a lithium salt and simultaneously forming a robust film on a surface of a positive electrode.

Abstract: The present invention relates to a method of preparing induced neural stem cells which are reprogrammed from differentiated cells. The method of producing the induced neural stem cells according to the present invention enables preparation of the induced neural stem cells from non-neuronal cells using only two inducing factors of SOX2 and HMGA2. Therefore, the method of the present invention can prepare induced neural stem cells in a more efficient manner than the conventional methods, which use four or five inducing factors. Additionally, the method of the present invention shows significantly higher inducing efficiency and proliferation capacity than when only a single SOX2 gene is used, thus increasing its potency to be used for therapeutic purposes.

Abstract: The present invention may provide a device and a method for detecting and diagnosing sleep apnea, which can accurately determine an apnea state by: extracting a respiration signal of an examinee from a received signal which is a reflection of an impulse signal emitted from at least one IR-UWB radar; setting a threshold value for determining an apnea state from changes in the deviation and interval between peaks of the extracted respiration signal; and comparing the set threshold value with the deviation between the peaks. Therefore, the sleep apnea can be accurately detected and diagnosed using a non-contact/noninvasive method, and thus inconvenience felt by the examinee can be reduced.

Abstract: The present invention relates to a coolant heater. The purpose of the present invention, a coolant heater which effectively heats coolant of a vehicle by means of a heating unit, is to provide a coolant heater having improved sensitivity and responsiveness to over-heating and assured stability by utilizing a temperature fuse to prevent over-heating. Another purpose of the present invention is to provide a coolant heater having enhanced durability of the temperature fuse coupling part by improving the structure by which the temperature fuse is fixed.

Abstract: An assembly for a seat includes a pivot hub defining multiple rotation axes, and a displacing module attached to the pivot hub. Extendable legs are rotatably coupled to the pivot hub and comprise locking devices movable between an unlocked position, in which the legs, when extended, are enabled to retract, and a locked position, in which the legs, when extended, are prevented from retracting. The legs are rotatable between an intermediate position and a deployed position. When the legs are extended, and when in the intermediate position, the displacing module engages the locking devices to move the locking devices from the locked position to the unlocked position. When the legs are extended, rotating the legs from the intermediate position to the deployed position brings the displacing module out of contact with the locking devices.

Abstract: The present disclosure relates to a device for fastening a lockbolt, the device comprising: a lockbolt gun including a body unit having a grip therein for pulling the lockbolt and a gripping unit protruding from a lower portion of the body unit and having an operation switch installed on the outside, wherein a hydraulic supply flow path for supplying hydraulic pressure for driving the grip, a hydraulic discharge flow path for discharging hydraulic pressure supplied to the grip, and an air supply flow path for supplying pneumatic pressure to the operation switch are installed in the gripping unit, and a discharge hole is formed outside the gripping unit to discharge air from the air supply flow path when the operation switch is operated; a driving force supply unit having a hydraulic supply pump that supplies hydraulic pressure to the hydraulic supply flow path, a hydraulic recovery pump that recovers hydraulic pressure discharged from the hydraulic discharge flow path, and an oil tank that supplies oil to the

Abstract: Provided is a method for prevention or treatment of a lysosomal storage disorder, and more particularly, to a method that may exhibit excellent efficacy against various lysosomal storage disorders including Niemann-Pick disease by including graphene quantum dots.

Abstract: A non-aqueous electrolyte for a lithium secondary battery and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte for a lithium secondary battery includes an organic solvent, a lithium salt, and a compound represented by Formula 1. In some embodiments, the compound represented by Formula 1 is present in an amount of 0.5 part by weight to 5 parts by weight based on 100 parts by weight of the non-aqueous electrolyte.

Abstract: A washing machine in which a detergent case is located below a washing tub unit and detergent and wash water are supplied from the detergent case to the washing tub unit by a pump. An overflow hole to prevent overflow of water to the outside the detergent case is provided on the detergent case, and the detergent and the wash water do not overflow the detergent case and are discharged to an outside of the washing machine through the overflow hole when the pump breaks down.