Abstract: The present disclosure provides methods and compositions of modified oligonucleotide primer and probe combinations, structurally modified with locked nucleic acids, quenchers, and dyes, effective to detect tumor-derived Human Papilloma Virus (HPV) and tumor-derived Epstein-Barr virus (EBV) and, especially, to distinguish viral DNA derived from tumors from viral DNA derived from infectious viral particles.

Abstract: Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Abstract: A movable operator station is disclosed. The movable operator station includes a first base plate, a second base plate, and a first support unit. A multi-tier structure is slidably coupled to the first base plate and is slidable in “X” axis between first and second positions. The second base plate is slidably coupled to the first base plate and is slidable between third and fourth positions. The first support unit is slidably coupled to the second base plate and is slidable along the “X” axis. A set of linking members links the first multi-tier structure to the first support unit. The set of linking members extends or collapses based on a movement of the second base plate along the “Y” axis. The first support unit and the set of linking members form a second multi-tier structure when the second base plate is at the fourth position.

Abstract: Embodiments of systems and methods for the centralized configuration of distributed heterogeneous services is disclosed herein. Embodiments of such systems and methods may be utilized to configure one or more service instances executing in an enterprise computing environment where each of the set of service instance is one of a set of service types that may be different. These services may, for example, be off-cloud services associated with a cloud based computing platform.

Abstract: Disclosed herein is system for buffering processor interrupts from active input devices, such as Bluetooth devices, so that they are aligned with a video refresh rate. The system may include a processor that operates in a first operating mode (e.g., a low power mode) and, in response to an interrupt request, switch to a second operating mode (e.g., a higher power mode). The first operating mode may be different from the second operating mode (e.g., each with a different level of power consumption). The system may also include a video subsystem, in communication with the processor, that provides video information at a refresh rate. The system may also include an input subsystem, such as a wireless communication system, in communication with the processor, that receives an activity trigger representing an activity of a input device, such as a human input device, and provides, based on the refresh rate, the activity trigger to the processor as the interrupt request.

Abstract: The present disclosure provides a process for assaying stability of monovalent and/or multivalent, liquid and lyophilized polysaccharide protein conjugate vaccine compositions using HPLC-SEC method. The method provides stability analysis (lot to lot) of polysaccharide protein conjugate vaccine with respect to aggregation profile, molar mass distribution and/or molecular size distribution, and data can be utilized for quality control during storage and batch release. The method is performed in the presence of multiple carrier proteins, free polysaccharides and excipient, without any interference of said components.

Abstract: Methods and systems are provided for managing user-configured custom routes for operating a vehicle. One method involves obtaining a user-configured route for operating a vehicle, providing a first graphical user interface (GUI) display including one or more GUI elements for receiving one or more user input values defining the user-configured route, automatically generating an identifier associated with the user-configured route based on the one or more user input values, and thereafter generating a graphical representation of the user-configured route that includes the autogenerated identifier associated with the user-configured route.

Abstract: Techniques for intelligent proactive template-driven data caching are disclosed. In one embodiment, a method is disclosed comprising receiving notification of input by the user of a user computing device, identifying a user activity corresponding to the user input, using the identified user activity to obtain a template comprising a number of data retrieval operations for the identified activity and timing information indicating, for each data retrieval operation, a corresponding timing for performing the data retrieval operation, performing a data retrieval operation identified by the template to retrieve data item(s) from data storage remote to the user computing device in accordance with the corresponding timing indicated by the template, causing the retrieved data items to be stored in data storage local to the user computing device.

Abstract: A system and method for testing a Light Detection and Ranging (LiDAR) sensor is disclosed. The system includes the LiDAR sensor radiating a plurality of LiDAR rays, a plurality of bars positioned at a predetermined distance from the LiDAR sensor, and a testing device. The method includes triggering a LiDAR sensor to radiate a plurality of LiDAR rays. The method further includes determining at least one intersection point at each of a plurality of bars upon intersection of at least one LiDAR ray from the plurality of LiDAR rays with each of the plurality of bars. The method further includes computing at least one operational parameter for the LiDAR sensor based on the intersection points, and determining one or more test results based on the one or more operational parameters.

Abstract: A method (200) for determining future resource requirements in a given location, the method comprising the steps of obtaining (110) transaction data, the transaction data indicative of past resource use at a given location. At least one model may be trained (120) based on a set of parameters by determining (121) a distribution associated with the transaction data; and generating (122) a kernel based on the distribution and the set parameters, the kernel being arranged to output an estimated distribution. The kernel is refined (123) and validated (124) based on a comparison between the distribution and the estimated distribution. A density map is then generated (125) based on the at least one trained model. The density map is then sent (130) to a control system for determining future resource requirements in the given location.

Abstract: The present disclosure is in the field of plant breeding and disease resistance. The disclosure provides methods for breeding corn plants having late wilt (LW) resistance using marker-assisted selection. The disclosure further provides corn germplasm resistant to LW. The disclosure also provides markers associated with LW resistance loci for introgressing these loci into elite germplasm in a breeding program, thus producing novel LW resistant germplasm.

Abstract: Statistical pattern recognition relies on substantial amount of annotated samples for better learning and learning is insufficient in low resource scenarios. Creating annotated databases itself is a challenging task, requires lot of effort and cost, which may not always be feasible. Such challenges are addressed by the present disclosure by generating synthetic samples through automatic transformation using Deep Autoencoders (DAE). An autoencoder is trained using all possible combination of pairs between a plurality of classes that could be formed from a limited number of handful samples in a low resource database, and then the DAE is used to generate new samples when one class samples are given as input to the autoencoder. Again, the system of the present disclosure can be configured to generate number of training samples as required. Also, the deep autoencoder can be dynamically configured to meet requirements.

Abstract: The present disclosure provides ?-diketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

Abstract: Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Provided herein are compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

Abstract: A hybrid entity recognition system and accompanying method identify composite entities based on machine learning. An input sentence is received and is preprocessed to remove extraneous information, perform spelling correction, and perform grammar correction to generate a cleaned input sentence. A POS tagger tags parts of speech of the cleaned input sentence. A rules based entity recognizer module identifies first level entities in the cleaned input sentence. The cleaned input sentence is converted and translated into numeric vectors. Basic and composite entities are extracted from the cleaned input sentence using the numeric vectors.

Abstract: Methods, apparatus, and computer-readable media are described to encode, by a first station (STA), a polling signal for periodic transmission to a second STA during each air activity instance of a plurality of air activity instances. The first STA detects an interface between a MAC layer and a software stack of a communication protocol is in a low-power state. The communication protocol is associated with a communication link between the first STA and the second STA. An empty packet from the second STA is decoded. The empty packet is received in response to the polling signal transmitted during an air activity instance of the plurality of air activity instances. The periodicity of the periodic transmission of the polling signal is adjusted based on the detected low-power state and the decoded empty packet.

Abstract: This disclosure generally relate to a method and system for network policy simulation in a distributed computing system. The present technology relates techniques that enable simulation of a new network policy with regard to its effects on the network data flow. By enabling a simulation data flow that is parallel and independent from the regular data flow, the present technology can provide optimized network security management with improved efficiency.

Abstract: Method for crude petroleum oil processing in Crude Distillation Unit is provided to eliminate the stripping steam in an Atmospheric Distillation Column (VDC) of CDU for a significant reduction in the CDU's operating cost and alleviating the corrosion in the overhead section of ADC. The present invention relates to a method of separating the components of crude petroleum oil. The proposed method utilizes the innovative application of process hydrocarbon vapour consisting of a lighter fraction of crude and natural gas. The conceptualized new schemes for downstream processing the Light and Heavy gas oil (LGO and HGO) distillates to meet their boiling specifications are also disclosed.

Abstract: The present invention relates to a system and method for controlling transdermal and automatic release of a sedative during imaging of a subject. A sedation level of a patient is detected during an imaging procedure. An amount of sedative to be applied to the patient to sustain a certain level of sedation is calculated. Further, a time for releasing the amount of the sedative is calculated. The calculated amount of the sedative is released at the calculated time transdermally to the patient.