Abstract: In an example embodiment, a natural language processing (NLP) machine learning and rules-based text extraction and analysis approach is used to convert a textual service recommendation document into customer-tailored actions considering the specific context-based executable script. This creates end-to-end automation in implementing suggestions provided in textual documents. Actions mentioned in the document can be processed automatically whenever possible, or at least transformed into a semi-automated action with system support. The solution can be configured to automate end-to-end converting of documents into personalized technical scripts and implementing these scripts at the customer-side.

Abstract: 7H-Pyrrolo[2,3-d]pyrimidine compound for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Abstract: The present disclosure relates to a method for operating a medical imaging system (100), the method carried out by use of a data processing unit (120), the method comprising: obtaining (SI), by a computational prediction model, time-invariant patient information, generating (S2), by the computational prediction model, a patient profile parametrized based on at least the obtained time-invariant patient information, obtaining (S3), by the computational prediction model, at least one current clinical workflow parameter, providing (S4), by the computational prediction model, a prediction comprising at least a patient-specific operation workflow based on at least correlating the generated patient profile with the obtained current clinical workflow parameter, wherein the patient-specific operation workflow comprises a specific one of a selection of operational modes of the medical imaging system, and operating the medical imaging system (100) based on the specific one of the selection of operational modes.

Abstract: The present disclosure relates to novel immunogenic monovalent and multivalent polysaccharide-protein conjugate vaccine compositions comprising a polysaccharide selected from Salmonella serovar strains S. typhi; S. paratyphi A; S. typhimurium and S. enteritidis and alternative improved methods of polysaccharide fermentation, polysaccharide purification, polysaccharide-protein conjugation and stable formulation. The present disclosure further relates to methods for inducing an immune response in subjects against Salmonella typhi and non-typhi related diseases and/or for reducing or preventing Salmonella typhi and non-typhi related diseases in subjects using the compositions disclosed herein. The vaccine elicits bactericidal antibodies and is useful for prevention of gastroenteritis, enteric and typhoid fever.

Abstract: The present invention is in the field of plant breeding and disease resistance. More specifically, the invention includes a method for breeding corn plants containing one or more markers that are associated with resistance to fungi. The invention further includes germplasm and the use of germplasm containing at least one marker associated with resistance to southern rust (SR) infection for introgression into elite germplasm in a breeding program, thus producing novel SR resistant germplasm.

Abstract: Techniques for improving system performance based on data characteristics are disclosed. A system may receive updates to a first data set at a first frequency. The system selects a first storage configuration, from a plurality of storage configurations, for storing the first data set based on the first frequency, and stores the first data set in accordance with the first storage configuration. The system may further receive updates to a second data set at a second frequency. The system selects a second storage configuration, from the plurality of storage configurations, for storing the second data set based on the second frequency, and stores the second data set in accordance with the second storage configuration. The second storage configuration is different than the first storage configuration.

Abstract: The present invention relates to detection of interactions between antigenic peptides and binding partners, such as T cell receptors (TCR) and antigenic peptide responsive T cells. In particular, the present invention relates to the provision of loadable detection molecules with peptide-free MHC molecules utilized for high throughput epitope identification and TCR specificity determination.

Abstract: A federated compliance management system operating in a cloud computing environment imports a repository-specific retention policy from a source information system operating in an enterprise computing environment and converts, using a policy mapping definition, the repository-specific retention policy into a federated retention policy. The policy mapping definition contains attribute mappings for federated attributes common across a plurality of information systems of disparate types, repository-specific attributes that are specific to an information system, and, where applicable, phase-common attributes that are common for all phases of an information system as well as phase-repository-specific attributes that are configured for a specific phase. The federated retention policy is stored in the cloud computing environment for use by the federated compliance management system, for instance, as a base policy for creating a repository-specific retention policy for a target system.

Abstract: The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise stabilized MHC class I molecules comprising a heavy chain comprising an alpha-1 domain and an alpha-2 domain connected by a disulfide bridge, wherein said MHC class I molecules are free of antigenic peptide. The scaffolds can be loaded with antigenic peptide on demand, providing an agile platform for effective expansion and functional stimulation of specific T cells in a peptide-MHC-directed fashion.

Abstract: An integrated circuit (IC), comprising a fuse structure (eFuse) formed in a resistive layer over a semiconductor substrate, the eFuse subject to a change in resistance through the controlled application of a programming current from a programming voltage source connected to a first terminal of the eFuse; a blow transistor formed on or over the substrate and having a control terminal configured to cause the programming current to flow through the eFuse in response to a programming signal; an intermediate transistor formed on or over the substrate and electrically coupled in series between a second terminal of the eFuse and the blow transistor; and, control circuitry formed on or over the substrate and electrically coupled to a node between the second terminal of the eFuse and the intermediate transistor, the control circuitry configured to reduce the flow of programming current through the eFuse in the event that a voltage detected at the node reaches a threshold level.

Abstract: A federated compliance management system operating in a cloud computing environment imports a repository-specific retention policy from a source information system operating in an enterprise computing environment and converts, using a policy mapping definition, the repository-specific retention policy into a federated retention policy. The policy mapping definition contains attribute mappings for federated attributes common across a plurality of information systems of disparate types, repository-specific attributes that are specific to an information system, and, where applicable, phase-common attributes that are common for all phases of an information system as well as phase-repository-specific attributes that are configured for a specific phase. The federated retention policy is stored in the cloud computing environment for use by the federated compliance management system, for instance, as a base policy for creating a repository-specific retention policy for a target system.

Abstract: A method and system for diagnosing autonomous vehicles is disclosed. The method includes identifying anomaly in a set of navigation parameters from a plurality of navigation parameters associated with the autonomous vehicle, such that each of the set of navigation parameters is above an associated risk threshold. The method further includes validating anomaly identified for each of the set of navigation parameters. The method includes generating a set of quality parameters for the set of navigation parameters in response to validating anomaly in the set of navigation parameters. The method further includes generating values of at least one motion parameter associated with the autonomous vehicle based on values of each of the set of quality parameters fed into a trained Artificial Intelligence (AI) model. The method includes controlling the at least one motion parameter based on the generated values.

Abstract: The present disclosure provides processes for preparing 1,2,3-tri-azole-4-carboxylic acid related compounds of formulae (I) and (II) via a Suzuki coupling reaction. The Suzuki coupling reaction is achieved by coupling a compound of formula (IV), a boron-containing derivative of 1,2,3-triazole-4-carb oxylate, with a cycloalkyl phenyl halide or sulfonate of formula (V).

Abstract: An example method includes detecting, using sensors, packets throughout a datacenter. The sensors can then send packet logs to various collectors which can then identify and summarize data flows in the datacenter. The collectors can then send flow logs to an analytics module which can identify the status of the datacenter and detect an attack.

Abstract: The present invention relates to a pharmaceutical formulation of siponimod which can be administered parenterally. In particular, the present invention relates to a parenteral solution comprising siponimod and a method for preparing said solution.

Abstract: Described herein are articles and methods of making articles, for example glass articles, comprising a thin sheet and a carrier, wherein the thin sheet and carrier are bonded together using a modification (coating) layer, for example a coating layer comprising a cationic surfactant or a coating layer comprising an organic salt, and associated deposition methods. The modification layer bonds the thin sheet and carrier together with sufficient bond strength to prevent delamination of the thin sheet and the carrier during high temperature (? 500° C.) processing while also preventing formation of a permanent bond between the sheets during such processing.

Abstract: This disclosure relates generally to method and system for providing assistance to interviewers. Technical interviewing is immensely important for enterprise but requires significant domain expertise and investment of time. The present disclosure aids assists interviewers with a framework via an interview assistant bot. The method initiates an interview session for a job description by selecting a set of qualified candidates resume to be interviewed. Further, the IA bot recommends each interviewer with a set of question and reference answer pairs prior initiating the interview. At each interview step, the IA bot records interview history and recommends interviewer with the revised set of questions. Further, an assessment score is determined for the candidate using the reference answer extracted from a resource corpus. Additionally, statistics about the interview process is generated, such as number and nature of questions asked, and its variation across to identify outliers for corrective actions.

Abstract: The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.

Abstract: A computer-implemented method for enabling a cloud connector system (100) to establish a secure connection between on-premise devices and a cloud server (108) hosting a cloud Certificate Lifecycle Management as a Service (CLMaaS) for validating and upgrading a certificate on the on-premise devices is provided. The method includes implementing a plurality of cloud connectors (102A-N) in a tenant premise comprising a plurality of on-premise devices (104A-N) to establish a full-duplex connection between the plurality of on-premise devices and the CLMaaS, performing a runtime analysis of the connection between the cloud server and the plurality of cloud connectors, routing the requests from the cloud CLMaaS to the plurality of on-premise devices through the plurality of cloud connectors based on the run time analysis of the connection, and enabling the cloud connector system to execute the certificate validation and upgradation in the on-premise devices based on the request from the cloud CLMaaS.

Abstract: Exemplary embodiments are directed to a device and method for controlling ambiance based on user-requested content. The device receives training data, user content requests, and user network device modification data. The device ascertains a content type for a user content request, performs analytics on the training data to create a model to predict ambiance settings, predicts ambiance settings for the content type using the model, evaluates the accuracy of the model and performs optimizations to the model to improve the predictions of the ambiance settings. The device controls the operating settings of one or more network devices based on the predicted ambiance settings. Moreover, exemplary embodiments are directed to controlling the enabling of display notifications, controlling reminder notifications, and controlling greeting notifications using a face identifier and notification settings.