Abstract: Disclosed herein are systems and methods capable of identifying, tracking, and sorting particles or droplets flowing in a channel, for example, a microfluidic channel having a fluid medium. The channel and the fluid medium can have a similar refractive index such that they appear translucent or transparent when illuminated by electromagnetic radiation. The particles or droplets can have a refractive index substantially different from that of the channel and the medium, such that the particles or droplets interfere with the electromagnetic radiation. A sensor can be disposed adjacent to the channel to record the electromagnetic radiation. The sensor can be attached to a system for identifying, tracking, and sorting the droplets.

Abstract: The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.

Abstract: High-throughput hyperspectral imaging systems are provided. According to an aspect of the invention, a system includes an excitation light source; an objective that is configured to image excitation light onto the sample, such that the excitation light causes the sample to emit fluorescence light; a channel separator that is configured to separate the fluorescence light into a plurality of spatially dispersed spectral channels; and a sensor. The excitation light source includes a light source and a plurality of lenslet arrays. Each of the lenslet arrays is configured to receive light from the light source and to generate a pattern of light, and the patterns of light generated by the lenslet arrays are combined to form the excitation light. The objective is configured to simultaneously image each of the patterns of light to form a plurality of parallel lines or an array of circular spots at different depths of the sample.

Abstract: A shunt valve for removing biofluid from an eye of a user, the valve including a tubular body defining an inlet and a plurality of outlets formed through a wall of the tubular body; a plunger accommodated within the tubular body and fluidically coupled to the inlet; wherein the plunger is movable relative to the plurality of outlets; and an energized material coupled to the plunger and the tubular body; wherein the energized material is compressible to expose a portion of the plurality of outlets dependent on the pressure applied to the energized material.

Abstract: An intraocular micro-display (IOMD) implant includes an enclosure shaped for implantation into an eye, a micro-display, a base lens, and an adjustable lens. The micro-display is disposed in the enclosure and oriented to emit an image towards a retina of the eye. The base lens has a fixed optical power, is attached to the enclosure, and is positioned relative to the micro-display to reside in an optical path extending between the micro-display and the retina. The base lens is configured to apply the fixed optical power to the image. The adjustable lens is disposed in the optical path between the micro-display and the retina. The adjustable lens has an adjustable optical power that is adjustable in-situ to adjust a focal distance of the image projected by the IOMD implant after the IOMD implant has been implanted into the eye.

Abstract: According to one embodiment, an intraocular pressure measurement system includes a pressure sensor implantable in an eye and comprising an optical cavity with an optical cavity depth that varies based on an intraocular pressure of the eye. The system further includes an external device for emitting light and measuring intraocular pressure based on reflected light. In an embodiment, the external device includes a light source configured to emit a plurality of beams, and a spectrometer configured to receive light reflected from at least two beams and produce an output based on the light reflected from the at least two beams. The output varies based on the depth of the optical cavity. The external device further includes a processor configured to receive the output and, based on the output, estimate the intraocular pressure of the eye.

Abstract: An intraocular micro-display (IOMD) system includes an auxiliary head unit. The auxiliary head unit includes a frame for mounting to a head of a user, a scene camera module mounted in or on the frame in a forward-facing orientation, a gaze tracking module disposed in or on the frame and configured to monitor an eye of the user, and an auxiliary controller. The auxiliary controller includes for: acquiring a scene image with the scene camera module, determining a gazing direction of the eye based upon gaze direction data from the gaze tracking module, identifying a sub-portion of the scene image based upon the gazing direction, and wirelessly relaying the sub-portion of the scene image to an IOMD implant within the eye for displaying to a retina of the eye.

Abstract: High-throughput hyperspectral imaging systems are provided. According to an aspect of the invention, a system includes an excitation light source; an objective that is configured to image excitation light onto the sample, such that the excitation light causes the sample to emit fluorescence light; a channel separator that is configured to separate the fluorescence light into a plurality of spatially dispersed spectral channels; and a sensor. The excitation light source includes a light source and a plurality of lenslet arrays. Each of the lenslet arrays is configured to receive light from the light source and to generate a pattern of light, and the patterns of light generated by the lenslet arrays are combined to form the excitation light. The objective is configured to simultaneously image each of the patterns of light to form a plurality of parallel lines or an array of circular spots at different depths of the sample.

Abstract: Systems and methods for determining the identity of a liquid within a liquid dispenser are provided. A device includes a holder having an opening that is configured to retain the liquid dispenser. A surface of the liquid dispenser is configured to affix a label identifying a liquid within the liquid dispenser. A plurality of lenses are mounted on the holder. Each lens has a respective field of view that includes a respective portion of the surface of the liquid dispenser. In addition, the device includes a plurality of fiber bundles. Each fiber bundle includes an input that is configured to receive a respective signal from a respective one of the plurality of lenses. Further, the device includes an imaging sensor that is configured to receive the respective signals from the plurality of fiber bundles and to form a plurality of images of the surface of the liquid dispenser.

Abstract: Systems, apparatuses, and methods for detecting carious lesions are described herein. In an example, the systems in an optical interrogator including a single-pixel photodetector responsive to short-wave infrared light and operatively coupled to a controller. In an example the optical interrogator includes a plurality of lasers for emitting laser light, a scanning mirror assembly and a single-pixel photodetector. In an example, the methods include causing the plurality of lasers to emit the laser light having wavelengths in a range of about 900 nm to about 1,700 nm; selectively directing the laser light over different portions of a tooth with a scanning mirror assembly to provide scattered light; and correlating scattered light signals generated by the single-pixel photodetector in response to the scattered light with the portion of the tooth.

Abstract: Systems and methods for filtering an optical beam are described. In one implementation, a system for filtering an input optical beam includes a first beamsplitter, a first spectral slicing module, a second spectral slicing module, and a second beamsplitter. The first beamsplitter is configured to split the input optical beam into a first optical beam and a second optical beam. The first spectral slicing module has a first passband and is configured to filter the first optical beam. The second spectral slicing module has a second passband and is configured to filter the second optical beam. The second beamsplitter is configured to combine the first optical beam and the second optical beam into an output optical beam. The first and second spectral slicing modules may each comprise a longpass filter and a shortpass filter aligned along its optical axis, and the longpass filter and/or the shortpass filter are rotatable relative to the optical axis.

Abstract: The present disclosure relates to optical systems for fluorescence-based imaging. An example optical system includes an image sensor. The image sensor is sensitive to at least a first wavelength of light and a second wavelength of light. The optical system also includes a light guiding layer optically coupled to the image sensor and a light source positioned to emit light into a side surface of the light guiding layer. The emitted light includes light at the first wavelength and the emitted light is transmitted in an in-plane direction in the light guiding layer. The optical system further includes a thin film filter and an output coupler optically coupled to the light guiding layer. At least a portion of the emitted light transmitted in an in-plane direction in the light guiding layer is coupled out of the light guiding layer in an out-of-plane direction via the output coupler.

Abstract: A system for medical diagnosis includes a fiber optic cable and a plurality of light emitters optically coupled to a first end of the fiber optic cable. Each light emitter in the plurality of light emitters emits a distinct bandwidth of light. The system also includes a controller electrically coupled to the plurality of light emitters. The controller includes logic that when executed by the controller causes the controller to perform operations including: receiving instructions including an illumination mode, and adjusting an intensity of the light emitted from each light emitter in the plurality of light emitters to match the illumination mode.

Abstract: The present disclosure relates to systems and methods for epi-fluorescence collection. An example system includes an optical element, one or more light sources, and an image sensor. The optical element includes at least one high reflectivity (HR) coating portion and at least one anti-reflection (AR) coating portion. The light source(s) is/are optically-coupled to the optical element along a first optical axis. The one or more light sources emit excitation light, which interacts, via the optical element, with a sample. The sample includes a fluorophore that emits emission light in response to the excitation light. The image sensor is optically-coupled to the optical element along a second optical axis. The image sensor detects the emission light via the optical element.

Abstract: High-throughput hyperspectral imaging systems are provided. According to an aspect of the invention, a system includes an excitation light source; an objective that is configured to image excitation light onto the sample, such that the excitation light causes the sample to emit fluorescence light; a channel separator that is configured to separate the fluorescence light into a plurality of spatially dispersed spectral channels; and a sensor. The excitation light source includes a light source and a plurality of lenslet arrays. Each of the lenslet arrays is configured to receive light from the light source and to generate a pattern of light, and the patterns of light generated by the lenslet arrays are combined to form the excitation light. The objective is configured to simultaneously image each of the patterns of light to form a plurality of parallel lines or an array of circular spots at different depths of the sample.

Abstract: Devices, systems, and associated methods for detecting drops dispensed by a dropper are provided. For example, a drop detection device may include a light source and a light detector configured to be coupled to a drop dispenser such that the light source and light detector are disposed proximal of a distal dispensing tip of the drop dispenser. The light detector may be configured to receive a reflected portion of a beam of light from the light source, which is reflected by a drop dispensed through the dispensing tip of the drop dispenser. In some embodiments, a processing circuit is configured to analyze a signal provided by the light detector to detect the dispensed drop.

Abstract: A system for medical diagnosis includes a fiber optic cable and a plurality of light emitters optically coupled to a first end of the fiber optic cable. Each light emitter in the plurality of light emitters emits a distinct bandwidth of light. The system also includes a controller electrically coupled to the plurality of light emitters. The controller includes logic that when executed by the controller causes the controller to perform operations including: receiving instructions including an illumination mode, and adjusting an intensity of the light emitted from each light emitter in the plurality of light emitters to match the illumination mode.

Abstract: High-throughput hyperspectral imaging systems are provided. According to an aspect of the invention, a system includes an excitation light source; an objective that is configured to image excitation light onto the sample, such that the excitation light causes the sample to emit fluorescence light; a channel separator that is configured to separate the fluorescence light into a plurality of spatially dispersed spectral channels; and a sensor. The excitation light source includes a light source and a plurality of lenslet arrays. Each of the lenslet arrays is configured to receive light from the light source and to generate a pattern of light, and the patterns of light generated by the lenslet arrays are combined to form the excitation light. The objective is configured to simultaneously image each of the patterns of light to form a plurality of parallel lines or an array of circular spots at different depths of the sample.

Abstract: Systems and methods for determining the identity of a liquid within a liquid dispenser are provided. A device includes a holder having an opening that is configured to retain the liquid dispenser. A surface of the liquid dispenser is configured to affix a label identifying a liquid within the liquid dispenser. A plurality of lenses are mounted on the holder. Each lens has a respective field of view that includes a respective portion of the surface of the liquid dispenser. In addition, the device includes a plurality of fiber bundles. Each fiber bundle includes an input that is configured to receive a respective signal from a respective one of the plurality of lenses. Further, the device includes an imaging sensor that is configured to receive the respective signals from the plurality of fiber bundles and to form a plurality of images of the surface of the liquid dispenser.

Abstract: The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.