Abstract: A system for medical diagnosis includes a fiber optic cable and a plurality of light emitters optically coupled to a first end of the fiber optic cable. Each light emitter in the plurality of light emitters emits a distinct bandwidth of light. The system also includes a controller electrically coupled to the plurality of light emitters. The controller includes logic that when executed by the controller causes the controller to perform operations including: receiving instructions including an illumination mode, and adjusting an intensity of the light emitted from each light emitter in the plurality of light emitters to match the illumination mode.

Abstract: A system for fluorescence activated cell sorting includes at least two excitation lasers having different orientations relative to an objective such that light from the at least two lasers passes through the objective and intersects a fluidic channel at different positions within an interrogation region. The fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region. The system further includes at least one detector and at least one optical element that directs light emitted from the plurality of fluorescently labeled particles and transmitted through the objective to the at least one detector. The system may further include optics for generating and detecting side and forward scattered light. Methods for operating example systems to collect fluorescent, side scattered and forward scattered light from a plurality of particles are also described herein.

Abstract: A system for fluorescence activated cell sorting includes at least two excitation lasers and an objective that directs light from the at least two excitation lasers to a common point in an interrogation region of a fluidic channel. The fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region. At least one modulator temporally multiplexes light from the at least two excitation lasers such that pulses of light from different lasers intersect the common point at different times. The system further includes at least one detector and at least one optical element that directs light emitted from the particles and transmitted through the objective to the at least one detector. The system may further include optics for generating and detecting side and forward scattered light. Methods for operating example systems to collect fluorescent, side scattered and forward scattered light are also described herein.

Abstract: Systems and methods for filtering an optical beam are described. In one implementation, a system for filtering an input optical beam includes a first beamsplitter, a first spectral slicing module, a second spectral slicing module, and a second beamsplitter. The first beamsplitter is configured to split the input optical beam into a first optical beam and a second optical beam. The first spectral slicing module has a first passband and is configured to filter the first optical beam. The second spectral slicing module has a second passband and is configured to filter the second optical beam. The second beamsplitter is configured to combine the first optical beam and the second optical beam into an output optical beam. The first and second spectral slicing modules may each comprise a longpass filter and a shortpass filter aligned along its optical axis, and the longpass filter and/or the shortpass filter are rotatable relative to the optical axis.

Abstract: Systems and methods for dispersing an optical beam are disclosed. In one implementation, an optical system includes a first double Amici prism and a second double Amici prism. The first and second double Amici prisms are aligned along an optical axis of the system and configured to transmit the optical beam. At least one of the first and second double Amici prisms is rotatable relative to the other around the optical axis. Advantageously, the disclosed systems and methods allow for efficient and versatile adjustment of the magnitude and/or orientation of the dispersion of the optical beam.

Abstract: Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths, and a first set of optical elements that include a first spatial light modulator (SLM), at least one lens, and at least one dispersive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.

Abstract: Systems and methods for confocal imaging are described. In one implementation, a confocal imaging system may include a light source configured to emit excitation light having one or more wavelengths, a sample holder configured to hold a sample, a two-dimensional (2-D) imaging device, a first set of optical elements, and a second set of optical elements. The first set of optical elements may include a first spatial light modulator (SLM) and at least one lens. The first set of optical elements may together be configured to collimate the excitation light, apply a predetermined phase modulation pattern to the collimated excitation light, and illuminate the sample in an excitation pattern.

Abstract: Systems and methods for fluorescent microscopy are disclosed where fluorophores can be excited over an excitation band to emit light in a wide emission band. Simultaneous acquisition of multiple planes in the sample can be achieved using a modified form of confocal microscopy. In one implementation, an objective employs a lens having optics exhibiting a large degree of axial chromatic aberration, such that emissions from different axially spaced focal planes are encoded by wavelength. Advantageously, simultaneous acquisition of multiple focal planes encoded by color can be processed to obtain efficient and rapid three-dimensional imaging of a sample.

Abstract: An electronic device including an optical sensor for optically sensing an image of an input object such as a user's fingerprint is provided. The electronic device includes a display layer, a detector, a pinhole layer, a cover layer and an illuminator. The display layer is configured to generate light within a visible light spectrum. The detector is configured to be sensitive to a wavelength of light. The pinhole layer is located above both the display layer and the detector. The cover layer is located above the pinhole layer, and the illuminator is configured to illuminate a sensing region of the cover layer with the wavelength of light. Further, the pinhole layer has an array of pinhole apertures formed in a material substantially transparent to the light generated by the display layer and substantially opaque to the wavelength of light from the illuminator.

Abstract: Various systems for imaging are provided. An electronic device includes a biometric sensor and a processing system. The biometric sensor includes an illuminator, a mirror, a biometric sensor array and a beam splitter. The beam splitter splits a beam received from the illuminator into a first beam incident on a biometric sensing area and a second beam incident on the mirror. The beam splitter combines the reflected beams from the biometric sensing area and the mirror. Thereafter, the processing system receives data from the sensor array and reconstructs the biometric image.

Abstract: Photodarkening in active fiber or waveguide devices (e.g. lasers, amplifiers, and incoherent sources such as ASE sources) can be reduced by altering the dopant concentration along the length of the doped fiber. A fiber or waveguide device includes two or more intentionally doped fiber or waveguide sections having different concentrations of one or more dopants. The dopants provide optical gain responsive to pump radiation provided to the fiber device by a pump source. A first optical intensity in a first of the fiber or waveguide sections is greater than a second optical intensity in a second of the fiber or waveguide sections. A first dopant concentration in the first fiber or waveguide section is lower than a second dopant concentration in the second fiber or waveguide section. Thus the dopant concentration is reduced in sections of the fiber or waveguide device having a higher optical intensity. The optical intensity can be due to pump radiation and/or signal radiation.

Abstract: Photodarkening in active fiber or waveguide devices (e.g. lasers, amplifiers, and incoherent sources such as ASE sources) can be reduced by altering the dopant concentration along the length of the doped fiber. A fiber or waveguide device includes two or more intentionally doped fiber or waveguide sections having different concentrations of one or more dopants. The dopants provide optical gain responsive to pump radiation provided to the fiber device by a pump source. A first optical intensity in a first of the fiber or waveguide sections is greater than a second optical intensity in a second of the fiber or waveguide sections. A first dopant concentration in the first fiber or waveguide section is lower than a second dopant concentration in the second fiber or waveguide section. Thus the dopant concentration is reduced in sections of the fiber or waveguide device having a higher optical intensity. The optical intensity can be due to pump radiation and/or signal radiation.