Abstract: The present invention relates to modified, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and intermediates thereof. More particularly, the present invention relates to improved processes for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.

Abstract: The present invention relates to a bio-assisted treatment of wastewater containing sulphide, phenols and hydrocarbons. Further, the present invention relates to a process for eliminating sulphide and other sulphur compounds including, but not limited to, mercaptans, disulfides, PAHs, phenols and hydrocarbons.

Abstract: In some configurations, the method of operating a system with dynamic wireless network topology with reduced spectrum flooding involve scanning with a first device in mesh network for beacon packets from other devices in the mesh network during a random back off period. In response to the first device not receiving a beacon packet from the other devices during the random back off period, the first device initiates an election protocol by sending an election protocol packet with its unique election protocol identifier to the other devices. In response to receiving a beacon packet from a second device, the first device stores the unique node identifier, assigns the second device as a leader node device, retransmits the unique node identifier of the second device and leader node information in a protocol packet. A command packet is communicated through the mesh network by way of at least one leader node device.

Abstract: A system for hands-free nursing and breast pumping includes a breast compression device with a plurality of thermoformed fluid bladders designed to fit adjustably against each breast and inflate and deflate with minimal power requirements. The compression device and its controller fit inside of a nursing garment designed to receive the device and controller for optimal compression. The nursing garment and the compression device have openings over the nipples so that a breast pump flange can be inserted through them and used in a typical manner for the extraction of breast milk, thus increasing the amount of milk expressed.

Abstract: An end effector for a surgical stapling device includes an anvil, a multiple use loading unit, and an ejector assembly. The multiple use loading unit is pivotally secured to the anvil and includes a channel member defining a cavity and a staple cartridge received within the cavity. The staple cartridge has a distal portion having an angled lower surface. The ejector assembly includes an ejector button that is supported on the channel member and engages the angled lower surface of the staple cartridge such that movement of the ejector button from an advanced position to a retracted position in relation to the channel member lifts the distal portion of the staple cartridge from the cavity of the channel member.

Abstract: The compounds herein disclosed are N-substituted tetrahydroisoquinoline ethylbenzamide compounds that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-substituted tetrahydroisoquinoline ethylbenzamide compounds have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6- to 10-fold less than the IC50 of Tamoxifen.

Abstract: In some configurations, the method of operating a system with dynamic wireless network topology with reduced spectrum flooding involve scanning with a first device in mesh network for beacon packets from other devices in the mesh network during a random back off period. In response to the first device not receiving a beacon packet from the other devices during the random back off period, the first device initiates an election protocol by sending an election protocol packet with its unique election protocol identifier to the other devices. In response to receiving a beacon packet from a second device, the first device stores the unique node identifier, assigns the second device as a leader node device, retransmits the unique node identifier of the second device and leader node information in a protocol packet. A command packet is communicated through the mesh network by way of at least one leader node device.

Abstract: Very long instruction word (VLIW) instruction processing using a reduced-width processor is disclosed. In a particular embodiment, a VLIW processor includes a control circuit configured to receive a VLIW packet that includes a first number of instructions and to distribute the instructions to a second number of instruction execution paths. The first number is greater than the second number. The VLIW processor also includes physical registers configured to store results of executing the instructions and a register renaming circuit that is coupled to the control circuit.

Abstract: Techniques to manage applications, such as mobile apps, across multiple management domains are disclosed. In various embodiments, a set of one or more application management policies to be enforced with respect to a mobile device is received from a management entity to which a scope of authority to manage applications with respect to the mobile device has been delegated. A management agent on the mobile device is used to enforce the one or more application management policies with respect to applications and application data that are within the scope of authority delegated to the management entity.

Abstract: One or more computing devices, systems, and/or methods for monitoring levels of activity of client devices using a cluster of servers having a decentralized network architecture are provided, where over-counting, which may be caused by an uneven distribution of requests transmitted by the client devices to the cluster of servers, may be mitigated. For example, a request may be received by a first server, of the cluster of servers, from a client device. A first counter value associated with a level of activity of the client device may be incremented by a first number. One or more data packets may be transmitted to one or more servers of the cluster of servers. Each data packet of the one or more data packets may comprise an instruction to increment a counter value associated with the client device by a second number, which may be different than the first number.

Abstract: The present invention relates to novel, improved processes for the preparation of sodium glucose co-transporter 2 (SGLT-2) inhibitors and novel intermediates thereof. More particularly, the present invention relates to a novel, improved process for the preparation of gliflozin compounds such as empagliflozin and dapagliflozin, intermediates thereof. The product obtained from the processes of present invention may be amorphous or crystalline, or in the form of amorphous/crystalline solid dispersions/solutions with pharmaceutically acceptable polymers and preparation process thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for the prevention and/or treatment of diseases and conditions associated with SGLT-2 inhibition.

Abstract: A surgical stapling device includes tool assembly having a cartridge assembly, an anvil assembly, and a stabilization member that is supported on a distal portion of one of the cartridge and anvil assemblies. The cartridge assembly and the anvil assembly are coupled to each other by a pivot member such that the tool assembly is movable between open and clamped positions. The stabilizing member is movable when the tool assembly is in the clamped position from a first position disengaged with the other of the cartridge and anvil assemblies to a second position engaged with the other of the cartridge and anvil assemblies to define a predetermined tissue gap between the cartridge assembly and the anvil assembly.

Abstract: Systems and devices for monitoring, detecting, and removing fluid build-up found at various regions along a tracheal tube of an intubated patient. The fluid management system includes pressure and flow sensors for detecting whether there is fluid at the various regions along the tracheal tube, and a means for drawing out the fluid into collection jars. The system also includes lavage features that is able to rinse different the various regions along a tracheal tube. Also disclosed are respiration insertion devices that either couple to existing tracheal tubes or incorporate tracheal tubing, where the respiration insertion body has channels and ports that contact various regions along the tracheal tube. The combination of the fluid management system and the respiration insertion devices effectively monitor and remove fluid at various locations along a tracheal tube of an intubated patient.

Abstract: A method for preparing a hyper-cellulolytic catabolite derepressed mutants of ascomycetes fungus, especially variants of Penicillium funiculosum. Selection media used to isolate such variants include amorphous cellulose and a high concentration of glucose. Cellulase activities of mutant ID-10, in particular such as FPase and ?-glucosidase were 1.5 times higher than Penicillium funiculosum MRJ-16 (parent). Furthermore, fungal mutant morphology was changed and no pH adjustment was required throughout the enzyme production process.

Abstract: Techniques are provided for storage tier verification checks. A determination is made that a mount operation of an aggregate of a set of volumes stored within a multi-tier storage environment has completed. A first metafile and a second metafile are maintained to track information related to the storage of objects of a volume of the aggregate within a remote object store that is a tier of the multi-tier storage environment. A distributed verification is performed between the first metafile and the second metafile to identify an inconsistency. Accordingly, the first metafile and the second metafile are reconciled to address the inconsistency so that storage information within the first metafile and the second metafile are consistent.

Abstract: An example system in accordance with an aspect of the present disclosure includes an inspection engine and a forwarding engine. The inspection engine is to identify whether a tunneled network packet is associated with the multicast group address and a VNI that is contained in the mapping table. The forwarding engine is to forward or discard the packet in response to whether the VNI is contained in the mapping table.

Abstract: An object-based data storage service receives a request to store a data object in association with a smart data storage tier. Based at least in part on characteristics of the data object, the object-based data storage service identifies and stores the data object in a first location corresponding to a first data storage tier. The object-based data storage service monitors access to the data object to identify a second set of characteristics of the data object. This second set of characteristics is used to determine that the data object is to be transitioned to a second data storage tier. The object-based data storage service, based at least in part on this determination, stores the data object in a second location corresponding to the second data storage tier.

Abstract: A system includes a gas distribution network having sub-networks including a first sub-network, each sub-network including a pipe section having a gas safety device coupled to a gas safety valve. The gas safety device includes a pressure sensor, a shut off controller configured to shut off the gas safety valve, a computing device, and a communications module. A server is communicably coupled to the communications modules of the gas safety devices for that implements artificial intelligence (AI) which based on a current threat condition to the gas distribution network determines affected sub-networks. The server is for sending of a valve closing instruction signal to the gas safety device in the first sub-network during the current threat condition when the current threat condition is determined to affect the first sub-network. Responsive to the valve closing instruction signal, the gas safety device shuts off the gas safety valve in the first sub-network.

Abstract: A method for detecting and handling skew and spillover in in-memory hash join operations. To improve the detection of skew and spillover in parallel processing systems, a Poisson distribution of unique hash values to Units of Parallelism (UoPs) is employed to determine the number of rows per UoP and in turn, the potential of spillover at a UoP. Hash join plan options can be selected or adjusted to reduce the likelihood of spillover.

Abstract: Techniques to establish a communication system between an administrative node, such as a remote help desk, and an instance of a managed mobile app running on a mobile device are disclosed. In various embodiments, an indication is received to establish a help desk session associated with a mobile device. A help desk library embedded in mobile app code comprising a managed mobile app installed on the mobile device is used to provide the help desk session. The help desk library is configured to provide in real time to a help desk system external to the mobile device mobile app data associated with the managed mobile app while the managed mobile app is running on the mobile device.